The Interplay between Liver and Adipose Tissue in the Onset of Liver Diseases: Exploring the Role of Vitamin Deficiency

Autor: Ivan Tattoli, Aimee Rachel Mathew, Antonella Verrienti, Lucia Pallotta, Carola Severi, Fausto Andreola, Virve Cavallucci, Mauro Giorgi, Mara Massimi, Lapo Bencini, Marco Fidaleo

Publikováno v: Cells, Vol 13, Iss 19, p 1631 (2024)

The deficiency of vitamins, a condition known as “hidden hunger”, causes comprehensive pathological states. Research over the years has identified a relationship between liver diseases and hypovitaminosis or defects in vitamin metabolism. The exa

Externí odkaz: https://doaj.org/article/378248e021b44ccfb0f4ada4ff7afe47

The role of RIPK1 mediated cell death in acute on chronic liver failure

Autor: Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan

Publikováno v: Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2021)

Abstract Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis is a form of programmed lytic cell death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosp

Externí odkaz: https://doaj.org/article/2491ace6c56640c794f84a8922eb4c18

Biomarkers of extracellular matrix formation are associated with acute-on-chronic liver failure

Autor: Annarein J.C. Kerbert, Saurabh Gupta, Eman Alabsawy, Iwona Dobler, Ida Lønsmann, Andrew Hall, Signe Holm Nielsen, Mette J. Nielsen, Henning Gronbaek, Àlex Amoros, Dave Yeung, Jane Macnaughtan, Rajeshwar P. Mookerjee, Stewart Macdonald, Fausto Andreola, Richard Moreau, Vicente Arroyo, Paolo Angeli, Diana J. Leeming, William Treem, Morten A. Karsdal, Rajiv Jalan

Publikováno v: JHEP Reports, Vol 3, Iss 6, Pp 100355- (2021)

Background & Aims: Acute-on-chronic liver failure (ACLF) is characterised by organ failure(s), high short-term mortality, and, pathophysiologically, deranged inflammatory responses. The extracellular matrix (ECM) is critically involved in regulating

Externí odkaz: https://doaj.org/article/60899aef3e0647849024975785540415

Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH

Autor: Francesca Zanieri, Ana Levi, David Montefusco, Lisa Longato, Francesco De Chiara, Luca Frenguelli, Sara Omenetti, Fausto Andreola, Tu Vinh Luong, Veronica Massey, Juan Caballeria, Constantino Fondevila, Sriram S Shanmugavelandy, Todd Fox, Giuseppe Mazza, Josepmaria Argemi, Ramon Bataller, Lauren Ashley Cowart, Mark Kester, Massimo Pinzani, Krista Rombouts

Publikováno v: Cells, Vol 9, Iss 5, p 1237 (2020)

In non-alcoholic steatohepatitis (NASH), many lines of investigation have reported a dysregulation in lipid homeostasis, leading to intrahepatic lipid accumulation. Recently, the role of dysfunctional sphingolipid metabolism has also been proposed. H

Externí odkaz: https://doaj.org/article/fe3629388e72430cb790712e8041f30d

Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF

Autor: Cornelius Engelmann, Abeba Habtesion, Mohsin Hassan, Annarein JC. Kerbert, Linda Hammerich, Simone Novelli, Marco Fidaleo, Alexandra Philips, Nathan Davies, Sofia Ferreira-Gonzalez, Stuart J. Forbes, Thomas Berg, Fausto Andreola, Rajiv Jalan

Publikováno v: Engelmann, C, Habtesion, A, Hassan, M, Kerbert, A JC, Hammerich, L, Novelli, S, Fidaleo, M, Philips, A, Davies, N, Ferreira-Gonzalez, S, Forbes, S J, Berg, T, Andreola, F & Jalan, R 2022, ' Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF ', Journal of Hepatology, vol. 77, no. 5, pp. 1325-1338 . https://doi.org/10.1016/j.jhep.2022.07.006
Journal Hepathology

Background & Aims: Acute-on-chronic liver failure (ACLF) is characterised by high short-term mortality, systemic inflammation, and failure of hepatic regeneration. Its treatment is a major unmet medical need. This study was conducted to explore wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50997bbb1d2e7489e82625d1f4f96ff7
https://hdl.handle.net/20.500.11820/4c3ed0e6-23ac-4d92-9332-33beb91bd906