Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fausto A. Varela"'
Autor:
Carly E, Martin, Andrew S, Murray, Jacob R, Mackinder, Kimberley E, Sala-Hamrick, Michael G, Flynn, Joseph G, Lundgren, Fausto A, Varela, Karin, List
Publikováno v:
Biological Chemistry. 403:969-982
TMPRSS13 is a member of the type II transmembrane serine protease (TTSP) family. Here we characterize a novel post-translational mechanism important for TMPRSS13 function: proteolytic cleavage within the extracellular TMPRSS13 stem region located bet
Autor:
Bret D. Freudenthal, Fausto A. Varela
Publikováno v:
Biochemistry
DNA polymerases play vital roles in the maintenance and replication of genomic DNA by synthesizing new nucleotide polymers using nucleoside triphosphates as substrates. Deoxynucleoside triphosphates (dNTPs) are the canonical substrates for DNA polyme
Autor:
Lauren M. Tanabe, Carly E. Martin, Karin List, Thomas E. Hyland, Jacob R. Mackinder, Fausto A. Varela, Andrew S. Murray, Kimberley E. Sala-Hamrick
Publikováno v:
Oncogene
Breast cancer progression is accompanied by increased expression of extracellular and cell-surface proteases capable of degrading the extracellular matrix as well as cleaving and activating downstream targets. The type II transmembrane serine proteas
Autor:
Kimberley E. Sala-Hamrick, Fausto A. Varela, Jacob R. Mackinder, Victoria L. Foust, Sokol V. Todi, Carly E. Martin, Karin List, Thomas E. Hyland, Andrew S. Murray
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Cancer progression is often accompanied by increased levels of extracellular proteases capable of remodeling the extracellular matrix and promoting pro-cancerous signaling pathways by activating growth factors and receptors. The type II transmembrane
Autor:
Fausto A. Varela, Kimberley E. Sala-Hamrick, Jacob R. Mackinder, Karin List, Andrew S. Murray, Carly E. Martin, Evan C. Harrison, Joseph G. Lundgren
Publikováno v:
The Journal of Biological Chemistry
TMPRSS13, a member of the type II transmembrane serine protease (TTSP) family, harbors four N-linked glycosylation sites in its extracellular domain. Two of the glycosylated residues are located in the scavenger receptor cysteine-rich (SRCR) protein
Publikováno v:
Extracellular Targeting of Cell Signaling in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb3228fb58061a281a366551792937c
https://doi.org/10.1002/9781119300229.ch4
https://doi.org/10.1002/9781119300229.ch4
Autor:
Lauren M. Tanabe, Jordan M. White, Karin List, Sokol V. Todi, Andrew S. Murray, Andrew J. Schoenbeck, Fausto A. Varela, Thomas E. Hyland
TMPRSS13 is a member of the type II transmembrane serine protease (TTSP) family. Although various TTSPs have been characterized in detail biochemically and functionally, the basic properties of TMPRSS13 remain unclear. Here, we investigate the activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3123477c4079266da3d10b28ce4e510
https://europepmc.org/articles/PMC5592667/
https://europepmc.org/articles/PMC5592667/
Autor:
Olga O. Kozanian, Taleen Der-Ghazarian, Cynthia E. Britt, Fausto A. Varela, Cynthia A. Crawford
Publikováno v:
Behavioural Brain Research. 246:29-35
Early treatment with methylphenidate has a persistent effect on the affective (i.e., anxiety- and depressive-like) behaviors of adult rats and mice. Interestingly, age at methylphenidate exposure appears to be a critical determinant influencing the e
Autor:
Matthew S. Herbert, Taleen Der-Ghazarian, Leslie R. Amodeo, Cynthia A. Crawford, Fausto A. Varela, Arnold Gutierrez, Sergios Charntikov, Sanders A. McDougall
Publikováno v:
Neuroscience. 226:427-440
The irreversible receptor antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) has been used to study the ontogeny of dopamine (DA) receptor functioning in young and adult rats. Most notably, systemic administration of EEDQ blocks the DA
Carcinogenesis is accompanied by increased protein and activity levels of extracellular cell-surface proteases that are capable of modifying the tumor microenvironment by directly cleaving the extracellular matrix, as well as activating growth factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343b8aeecbba6747114fa36dea1c0483
https://europepmc.org/articles/PMC4981541/
https://europepmc.org/articles/PMC4981541/