Zobrazeno 1 - 10 of 65 pro vyhledávání: '"Fausta Ulgheri"'
1
Non-covalent inflammasome-caspase-1 complex inhibitors: New molecules targeting immune and inflammatory disorders including COVID-19
Autor: Giovanni Loriga, Andrea Morra, Fausta Ulgheri, Pietro Spanu, Maria Pia Fuggetta, Matthew Robert Groves, Alexander Dömling, Ajay Chandgudge, Francesco Deligia, Iris de Haan
Publikováno v: 6th International Electronic Conference on Medicinal Chemistry, Online, 01-30/11/2020
info:cnr-pdr/source/autori:Fausta Ulgheri, Pietro Spanu, Francesco Deligia, Giovanni Loriga, Maria Pia Fuggetta, Andrea Morra, Iris de Haan, Ajay Chandgudge, Matthew R. Groves 3, Alexander Domling/congresso_nome:6th International Electronic Conference on Medicinal Chemistry/congresso_luogo:Online/congresso_data:01-30%2F11%2F2020/anno:2020/pagina_da:/pagina_a:/intervallo_pagine
There is a growing evidence of the relation between an excessive release of pro-inflammatory IL-1beta triggered by the inflammasome-caspase 1 complex, and various immune and inflammatory disorders, including CNS diseases such as Alzheimer's (AD), Par
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3e1bdca870725ddc44b08754310326
https://publications.cnr.it/doc/441585
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2
A new synthetic spiroketal: Studies on antitumor activity on murine melanoma model in vivo and mechanism of action in vitro
Autor: Pietro Spanu, Adriano Barra, Alberto Mannu, Rosanna De Cicco, Veronica Trotta, Franco Morelli, Maria Pia Fuggetta, Francesco Deligia, Enrica Zona, Fausta Ulgheri, Paola Carta
Publikováno v: Anti-cancer agents in medicinal chemistry (Online) 19 (2019): 567–578. doi:10.2174/1871520619666190131141400
info:cnr-pdr/source/autori:Fuggetta M.P.; Spanu P.; Ulgheri F.; Deligia F.; Carta P.; Mannu A.; Trotta V.; Cicco R.D.; Barra A.; Zona E.; Morelli F./titolo:A new synthetic spiroketal: Studies on antitumor activity on murine melanoma model in vivo and mechanism of action in vitro/doi:10.2174%2F1871520619666190131141400/rivista:Anti-cancer agents in medicinal chemistry (Online)/anno:2019/pagina_da:567/pagina_a:578/intervallo_pagine:567–578/volume:19
Background:In a previous study, we synthesised a new spiroketal derivative, inspired to natural products, that has shown high antiproliferative activity, potent telomerase inhibition and proapoptotic activity on several human cell lines.Objective:Thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df8f163ad0eca28530ea99bb4df5ab1
http://hdl.handle.net/2318/1735702
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4
Caspasi, Miastenia Gravis e Distrofia Muscolare di duchenne
Autor: Pietro Spanu, Alexander Doemling, Francesco Deligia, Maria Pia Fuggetta, Ajay Chandgude, Philip H. Elsinga, Fausta Ulgheri
Publikováno v: XI Giornata Mondiale delle Malattie Rare, Sassari, 3 Marzo 2018
info:cnr-pdr/source/autori:Pietro Spanu, Alexander Doemling, Francesco Deligia, Maria Pia Fuggetta, Ajay Chandgude, Philip H. Elsinga, Fausta Ulgheri/congresso_nome:XI Giornata Mondiale delle Malattie Rare/congresso_luogo:Sassari/congresso_data:3 Marzo 2018/anno:2018/pagina_da:/pagina_a:/intervallo_pagine
Nuovi approcci terapeutici per la Miastenia Gravis e la Distrofia Muscolare di duchenne, le potenzialità di nuovi inibitori di caspasi-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ad1457ef079ff83e84d7389f2a854862
http://www.cnr.it/prodotto/i/395922
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5
A New synthetic spiroketal: Antitumor Activity On Murine Melanoma Model In Vivo and MOA In Vitro
Autor: Pietro Spanu, Maria Pia Fuggetta, Fausta Ulgheri, Francesco Deligia, Giovanni Loriga, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, Franco Morelli
Publikováno v: 4th International Electronic Conference on Medicinal Chemistry, 1-30 Novembre 2018
info:cnr-pdr/source/autori:Pietro Spanu, Maria Pia Fuggetta, Fausta Ulgheri, Francesco Deligia, Giovanni Loriga, Paola Carta, Alberto Mannu, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, Franco Morelli/congresso_nome:4th International Electronic Conference on Medicinal Chemistry/congresso_luogo:/congresso_data:1-30 Novembre 2018/anno:2018/pagina_da:/pagina_a:/intervallo_pagine
The natural-like spiroketal, 2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one (1) has been synthesised and has shown a potent antitumor activity against human tumor cells of different nature and histotype. We have now performed studies for veri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::04e67627b9224c2a6a5f43d781fc36a9
http://www.cnr.it/prodotto/i/395920
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6
2-hydroxy-8-methyl-1,7-dioxaspiro[5.5]undec-3-en-5-one: a Natural-Product-Inspired Spiroketal with in vivo Efficacy in Mouse Model of Melanoma
Autor: Pietro Spanu, Maria Pia Fuggetta, Fausta Ulgheri, Paola Carta, Francesco Deligia, Manuela Zonfrillo, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, Franco Morelli
Publikováno v: Conferenza di Dipartimento DSCTM 2017, Alghero, 19/10/2017,20/10/2017
info:cnr-pdr/source/autori:Pietro Spanu, Maria Pia Fuggetta,Fausta Ulgheri, Paola Carta, Francesco Deligia, Manuela Zonfrillo, Veronica Trotta, Rosanna De Cicco, Adriano Barra, Enrica Zona, and Franco Morelli/congresso_nome:Conferenza di Dipartimento DSCTM 2017/congresso_luogo:Alghero/congresso_data:19%2F10%2F2017,20%2F10%2F2017/anno:2017/pagina_da:/pagina_a:/intervallo_pagine
We have synthesised and identified a new promising antitumor agent with in vivo activity on a murine melanoma model. Compound 1 showed potent dose-dependent antitumor efficacy in syngenic C57Black mice murine model of melanoma, suppressing the tumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ac6fb780ee6b410a93317f005f300015
https://publications.cnr.it/doc/380230
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7
Potent Non-Covalent Inhibitors of Caspase-1 Targeting Neuroinflammation in Neurodegenerative Diseases
Autor: Fausta Ulgheri, Deligia F., Fuggetta M.P., Chandgude A. L., Elsinga P., de Vries E.F.J., Doorduin J., Kopschina Feltes P., Dolga A., Krabbendam I., Dömling A., Spanu P.
Publikováno v: Conferenza di Dipartimento DSCTM 2017, pp. 74–74, Alghero, 19/10/2017
info:cnr-pdr/source/autori:Fausta Ulgheri, Deligia F., Fuggetta M.P., Chandgude A. L., Elsinga P., de Vries E.F.J., Doorduin J., Kopschina Feltes P., Dolga A., Krabbendam I., Dömling A., Spanu P./congresso_nome:Conferenza di Dipartimento DSCTM 2017/congresso_luogo:Alghero/congresso_data:19%2F10%2F2017/anno:2017/pagina_da:74/pagina_a:74/intervallo_pagine:74–74
Recent studies have shown the pivotal role of innate immune activation in the pathogenesis of major neurodegenerative diseases. It has been discovered that microglia and other cell of the brain innate immune system, may be activated by misfolded prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::69356c6c5f452e4230efdc737fabf2a5
http://www.cnr.it/prodotto/i/380239
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8
An unexpected reaction of pyridine with acetyl chloride to give dihydropyridine and piperidine derivatives
Autor: Pietro Spanu, Alberto Mannu, Fausta Ulgheri
Publikováno v: Tetrahedron letters 55 (2014): 1939–1942. doi:10.1016/j.tetlet.2014.02.006
info:cnr-pdr/source/autori:Spanu P.; Mannu A.; Ulgheri F./titolo:An unexpected reaction of pyridine with acetyl chloride to give dihydropyridine and piperidine derivatives/doi:10.1016%2Fj.tetlet.2014.02.006/rivista:Tetrahedron letters/anno:2014/pagina_da:1939/pagina_a:1942/intervallo_pagine:1939–1942/volume:55
An unexpected reaction of pyridine with acetyl chloride to give N-acetyl-1,2 and 1,4-dihydropyridyl acetic acid (1, 2) in high yield and regioselectivity has been reported. The key step is the formation of a zwitterionic pyridinium ketene enolate. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80d301a63ac0fae4135e336c5ac9240
https://doi.org/10.1016/j.tetlet.2014.02.006
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9
Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity
Autor: Andrea Cottarelli, Atilio Reyes Romero, Fausta Ulgheri, Alexander Dömling, Mauro Marchetti, Maria Pia Fuggetta, Manuela Zonfrillo, Pietro Spanu, Giovanni N. Roviello, Franco Morelli, Alberto Mannu, Francesco Deligia, Antonella De Mico, Paola Peluso
Publikováno v: Journal of medicinal chemistry 59 (2016): 9140–9149. doi:10.1021/acs.jmedchem.6b01046
info:cnr-pdr/source/autori:Fuggetta MP, De Mico A, Cottarelli A, Morelli F, Zonfrillo M, Ulgheri F, Peluso P, Mannu A, Deligia F, Marchetti M, Roviello G, Reyes Romero A, Dömling A, Spanu P./titolo:Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity./doi:10.1021%2Facs.jmedchem.6b01046/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:9140/pagina_a:9149/intervallo_pagine:9140–9149/volume:59
EFMC INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY, pp. 290–290, MANCHESTER UK, 28/08/2016-01/09/2016
info:cnr-pdr/source/autori:Pietro Spanu, Antonella De Mico, Andrea Cottarelli, Franco Morelli, Manuela Zonfrillo, Fausta Ulgheri, Paola Peluso, Alberto Mannu, Francesco Deligia, Mauro Marchetti, Giovanni Roviello, Atilio Reyes Romero, Alexander Domling, Maria Pia Fuggetta/congresso_nome:EFMC INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY/congresso_luogo:MANCHESTER UK/congresso_data:28%2F08%2F2016-01%2F09%2F2016/anno:2016/pagina_da:290/pagina_a:290/intervallo_pagine:290–290
info:cnr-pdr/source/autori:Fuggetta, Maria Pia; De Mico, Antonella; Cottarelli, Andrea; Morelli, Franco; Zonfrillo, Manuela; Ulgheri, Fausta; Peluso, Paola; Mannu, Alberto; Deligia, Francesco; Marchetti, Mauro; Roviello, Giovanni; Romero, Atilio Reyes; Domling, Alexander; Spanu, Pietro/titolo:Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity/doi:10.1021%2Facs.jmedchem.6b01046/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:9140/pagina_a:9149/intervallo_pagine:9140–9149/volume:59
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 59(19), 9140-9149. AMER CHEMICAL SOC
Numerous complex natural products containing spiroketals framework, with a wide range of important biological activities, have been isolated over the years from marine or terrestrial sources. Many groups investigated the possibility to reduce the com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df517544df3ff63fa27db4791bc4f95d
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10
Individuazione di Nuovi Lead per la Cura di Patologie Neurodegenerative
Autor: Pietro Spanu, Fausta Ulgheri, Azzena Ugo, Pisano Luisa, Mocci Francesca
Il progetto Individuazione di nuovi lead per la cura di patologie neurogenerative, finanziato dalla Regione Sardegna (CRP 59740) si è concluso come previsto in data 27/08/2016. Nel rapporto in oggetto sono state descritte, in maniera dettagliata, le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::e3da4582b084cbcb28226cde89af28f0
http://www.cnr.it/prodotto/i/361736
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