Massively parallel genetic perturbation reveals the energetic architecture of an amyloid beta nucleation reaction.

Autor: Arutyunyan A, Seuma M, Faure AJ, Bolognesi B, Lehner B

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.

The genetic architecture of protein interaction affinity and specificity.

Autor: Bendel AM; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.; University of Basel, Basel, Switzerland.; Swiss Institute for Experimental Cancer Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Faure AJ; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; ALLOX, C/ Dr. Aiguader, 88, PRBB Building, Barcelona, Spain., Klein D; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Shimada K; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Lyautey R; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.; University of Basel, Basel, Switzerland., Schiffelholz N; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Kempf G; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Cavadini S; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Lehner B; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. bl11@sanger.ac.uk.; Universitat Pompeu Fabra (UPF), Barcelona, Spain. bl11@sanger.ac.uk.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. bl11@sanger.ac.uk.; Wellcome Sanger Institute, Hinxton, UK. bl11@sanger.ac.uk., Diss G; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland. guillaume.diss@fmi.ch.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 14; Vol. 15 (1), pp. 8868. Date of Electronic Publication: 2024 Oct 14.

An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity.

Autor: Faure AJ; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Lehner B; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Miró Pina V; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Serrano Colome C; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain., Weghorn D; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2024 May 28; Vol. 20 (5), pp. e1012132. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024).

Mapping the energetic and allosteric landscapes of protein binding domains.

Autor: Faure AJ; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Domingo J; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; New York Genome Center (NYGC), New York, NY, USA., Schmiedel JM; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Hidalgo-Carcedo C; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Diss G; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland., Lehner B; Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. ben.lehner@crg.eu.; Universitat Pompeu Fabra (UPF), Barcelona, Spain. ben.lehner@crg.eu.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ben.lehner@crg.eu.

Publikováno v: Nature [Nature] 2022 Apr; Vol. 604 (7904), pp. 175-183. Date of Electronic Publication: 2022 Apr 06.

Fitness landscape of a dynamic RNA structure.

Autor: Soo VWC; Medical Research Council London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom., Swadling JB; Medical Research Council London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom., Faure AJ; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Warnecke T; Medical Research Council London Institute of Medical Sciences, London, United Kingdom.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2021 Feb 01; Vol. 17 (2), pp. e1009353. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).