Zobrazeno 1 - 10
of 1 795
pro vyhledávání: '"Faull, P"'
Autor:
L. Maximilian Reuter, Sanjay P. Khadayate, Audrey Mossler, Korbinian Liebl, Sarah V. Faull, Mohammad M. Karimi, Christian Speck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment in S-phase. However, how ORC and MCM2-7 facilitate genome-wide DNA l
Externí odkaz:
https://doaj.org/article/bd43d4162ef44b5e9b689236ae3389f7
Autor:
Prabhleen Kaur, Simone Ciuti, Federico Ossi, Francesca Cagnacci, Nicolas Morellet, Anne Loison, Kamal Atmeh, Philip McLoughlin, Adele K. Reinking, Jeffrey L. Beck, Anna C. Ortega, Matthew Kauffman, Mark S. Boyce, Amy Haigh, Anna David, Laura L. Griffin, Kimberly Conteddu, Jane Faull, Michael Salter-Townshend
Publikováno v:
Movement Ecology, Vol 12, Iss 1, Pp 1-36 (2024)
Abstract Background Social network analysis of animal societies allows scientists to test hypotheses about social evolution, behaviour, and dynamic processes. However, the accuracy of estimated metrics depends on data characteristics like sample prop
Externí odkaz:
https://doaj.org/article/013bea233d014622b4636ed6778c22b4
Autor:
Eleanor Wilson, Jonathan Palmer, Alison Armstrong, Ben Messer, Edward Presswood, Christina Faull
Publikováno v:
BMC Palliative Care, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Motor Neurone Disease (MND) leads to muscle weakening, affecting movement, speech, and breathing. Home mechanical ventilation, particularly non-invasive ventilation (NIV), is used to alleviate symptoms and support breathing in peo
Externí odkaz:
https://doaj.org/article/a3ba7d150e3d409aa7ae8a3399987223
Microglial proliferation and astrocytic protein alterations in the human Huntington's disease cortex
Autor:
Adelie Y.S. Tan, Lynette J. Tippett, Clinton P. Turner, Molly E.V. Swanson, Thomas I.H. Park, Maurice A. Curtis, Richard L.M. Faull, Mike Dragunow, Malvindar K. Singh-Bains
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106554- (2024)
Huntington's disease (HD) is a neurodegenerative disorder that severely affects the basal ganglia and regions of the cerebral cortex. While astrocytosis and microgliosis both contribute to basal ganglia pathology, the contribution of gliosis and pote
Externí odkaz:
https://doaj.org/article/b55a6aaec4d04011a25fb03e9a9414ad
Autor:
Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-negative bacterium best known for its role in chronic periodontitis. Gingipains were recently identified in the middle temporal gyrus of postmortem Alzhei
Externí odkaz:
https://doaj.org/article/e8b7aafa120347438648a23f9c4049de
Autor:
Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitati
Externí odkaz:
https://doaj.org/article/4c4d2aa5f2d24e1cbc0429058653faa3
Autor:
James A. Wiseman, Helen C. Murray, Richard L. M. F. Faull, Michael Dragunow, Clinton P. Turner, Birger Victor Dieriks, Maurice A. Curtis
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract In Parkinson’s disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates form a myriad of conformational and truncational variants. Most antibodies used to detect and quantify α-Syn in the human brain target epitopes
Externí odkaz:
https://doaj.org/article/bfdc8b86e92a4efbb9294b4b59a33ad1
Autor:
Elizabeth Cooper, Caitlin R. M. Oyagawa, Rebecca Johnson, Peter J. Choi, Jena Macapagal Foliaki, Jason Correia, Patrick Schweder, Peter Heppner, Edward Mee, Clinton Turner, Richard Faull, William A. Denny, Mike Dragunow, Jiney Jose, Thomas I-H. Park
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Glioblastoma is the most common and aggressive primary brain tumour in adults. The development of anti-brain cancer agents are challenged by the blood-brain barrier and the resistance conferred by the local tumour microenvironment. Heptameth
Externí odkaz:
https://doaj.org/article/e89e926fe6974ecaa78c8ebfb63ce277
Autor:
Christopher E. Ramsden, Daisy Zamora, Mark S. Horowitz, Jahandar Jahanipour, Elizabeth Calzada, Xiufeng Li, Gregory S. Keyes, Helen C. Murray, Maurice A. Curtis, Richard M. Faull, Andrea Sedlock, Dragan Maric
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-31 (2023)
Abstract In sporadic Alzheimer’s disease (sAD) specific regions, layers and neurons accumulate hyperphosphorylated Tau (pTau) and degenerate early while others remain unaffected even in advanced disease. ApoER2-Dab1 signaling suppresses Tau phospho
Externí odkaz:
https://doaj.org/article/e3736605578a4ed187f90e071e5def20
Autor:
Tracy Long-Sutehall, Anna Zatorska, Michelle Myall, Christina Faull, Adam Hurlow, Sarah Mollart, Clare Rayment, Jill Short, Jane Wale, Emma Winstanley, Mike Bracher
Publikováno v:
BMC Palliative Care, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Objectives New routes for supply of eye tissue are needed in the UK to support transplant surgery and medical research. Hospice care (HC) and Hospital-based Palliative care (HPC) services represent potential supply routes. This paper reports
Externí odkaz:
https://doaj.org/article/f6262baf8f2444f8b22c7610a22718b0