Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Fatma Tat"'
Autor:
David M. Goldenberg, David V. Gold, Fatma Tat, Robert M. Sharkey, Thomas M. Cardillo, Serengulam V. Govindan
PDF file - 1.5 MB, Reversed-phase HPLC analyses for cleavage of ME-capped CL2E-SN-38 by cathepsin-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833d8b5d4fa0b26c7c9ddb98c9f40638
https://doi.org/10.1158/1535-7163.22500259.v1
https://doi.org/10.1158/1535-7163.22500259.v1
Autor:
David M. Goldenberg, David V. Gold, Fatma Tat, Robert M. Sharkey, Thomas M. Cardillo, Serengulam V. Govindan
PDF file - 60 KB, Reversed-phase HPLC analyses of cathepsin B incubates and buffer control incubates of ME-CL2A-SN-38, pH 5, 37 degrees Celsius. Values represent % of applied product.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c64711050f2225475ff0f0bb59416
https://doi.org/10.1158/1535-7163.22500247
https://doi.org/10.1158/1535-7163.22500247
Autor:
David M. Goldenberg, David V. Gold, Fatma Tat, Robert M. Sharkey, Thomas M. Cardillo, Serengulam V. Govindan
CD74 is an attractive target for antibody–drug conjugates (ADC), because it internalizes and recycles after antibody binding. CD74 mostly is associated with hematologic tumors but is expressed also in solid cancers. Therefore, ADCs of the humanized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e648ecf567c521d924f6481502a382b
https://doi.org/10.1158/1535-7163.c.6536407.v1
https://doi.org/10.1158/1535-7163.c.6536407.v1
Publikováno v:
Journal of Dr. Behcet Uz Children's Hospital. 1:37-41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c8994432d1ce6c33dbd91d5c2aa976d
https://doi.org/10.5222/buchd.2011.037
https://doi.org/10.5222/buchd.2011.037
Autor:
David M. Goldenberg, Fatma Tat, Thomas M. Cardillo, David V. Gold, Robert M. Sharkey, Serengulam V. Govindan
Publikováno v:
Molecular cancer therapeutics. 12(6)
CD74 is an attractive target for antibody–drug conjugates (ADC), because it internalizes and recycles after antibody binding. CD74 mostly is associated with hematologic tumors but is expressed also in solid cancers. Therefore, ADCs of the humanized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc36b1b767c08c9c3cec47b3e7faa1f9
https://pubmed.ncbi.nlm.nih.gov/23427296
https://pubmed.ncbi.nlm.nih.gov/23427296
Publikováno v:
Infectious Diseases in Clinical Practice. 20:152-153
Sphingomonas paucimobilis, which was previously named as Pseudomonas paucimobilis in 1977 as an etiologic agent of human infection, is a nonfermenting gram-negative bacillus found in soil and water. Limited reports of S paucimobilis infection have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::922b406d9da8f489e21f4288b9921ab9
https://doi.org/10.1097/ipc.0b013e31821f890a
https://doi.org/10.1097/ipc.0b013e31821f890a
Autor:
Roberto Arrojo, Thomas M. Cardillo, Fatma Tat, Serengulam V. Govindan, David M. Goldenberg, Robert M. Sharkey
Publikováno v:
Cancer Research. 72:2526-2526
We reported therapeutic results of antibody (MAb) conjugates of the topo I inhibitor, SN-38, in human tumor xenografts in nude mice. These involved SN-38 derivatives, CL2-SN-38 (maleimido-[x]-Phe-Lys-PABOCO-20-O-SN-38) and its ‘Phe’-deleted varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0097b8ae668a5ec424e8245955f26b69
https://doi.org/10.1158/1538-7445.am2012-2526
https://doi.org/10.1158/1538-7445.am2012-2526
Autor:
Preeti Trisal, Henry W. Founds, Robert M. Sharkey, David M. Goldenberg, Thomas M. Cardillo, Fatma Tat, Serengulam V. Govindan
Publikováno v:
Cancer Research. 71:3619-3619
Antibody drug conjugates (ADCs) of the topoisomerase I inhibitor, SN-38, that allowed for a slow release of SN-38 from the ADC over time, were prepared using anti-CEACAM5 MAb, labetuzumab (hMN-14), anti-TROP-2 MAb, hRS7, and other MAbs by thiol-malei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ac7743c7f5fbc00acc1481b34d60d2
https://doi.org/10.1158/1538-7445.am2011-3619
https://doi.org/10.1158/1538-7445.am2011-3619
Autor:
Fatma Tat, Agatha Sheerin, David M. Goldenberg, Anju Nair, Maria Zalath, Thomas M. Cardillo, Sung-Ju Moon, Robert M. Sharkey, Serengulam V. Govindan
Publikováno v:
Cancer Research. 70:2438-2438
Antibody (MAb) conjugates of the potent topoisomerase I inhibitor, SN-38, have been previously shown by our groups to be efficacious in the targeted therapies of human cancer xenografts in nude mice. The conjugates have since been redesigned with a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9b093b0ed1b0233b4c0e06a6ecf6394
https://doi.org/10.1158/1538-7445.am10-2438
https://doi.org/10.1158/1538-7445.am10-2438