Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients.

Autor: Sayeh Ezzikouri, Rhimou Alaoui, Khadija Rebbani, Ikram Brahim, Fatima-Zohra Fakhir, Salwa Nadir, Helmut Diepolder, Salim I Khakoo, Mark Thursz, Soumaya Benjelloun

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54793 (2013)

BACKGROUND:Genetic variation in the IL28B gene has been strongly associated with treatment outcomes, spontaneous clearance and progression of the hepatitis C virus infection (HCV). The aim of the present study was to investigate the role of polymorph

Externí odkaz: https://doaj.org/article/08f6ebe34f0448cdb5c44536d9c329f3

Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells

Autor: Fatima-Zohra Fakhir, Alexis Gonneaud, Elisabeth Chartier-Garcia, Alexandre Chenal, C. Marquette, Emeline Landas, Christine Almunia, Vincent Forge, Enora Le Tallec

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2020, 21 (20), pp.7625. ⟨10.3390/ijms21207625⟩
International Journal of Molecular Sciences, MDPI, 2020, 21 (20), pp.7625. ⟨10.3390/ijms21207625⟩
International Journal of Molecular Sciences, Vol 21, Iss 7625, p 7625 (2020)
Volume 21
Issue 20

Bcl-xL, a member of the Bcl-2 family, is a pro-survival protein involved in apoptosis regulation. We have previously reported the ability of Bcl-xL to form various types of fibers, from native to amyloid conformations. Here, we have mimicked the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa09ce3f893890d38e9ea3f6d9fca85c
https://doi.org/10.3390/ijms21207625

The -94Ins/DelATTG polymorphism in NFκB1 promoter modulates chronic hepatitis C and liver disease progression

Autor: Soumaya Benjelloun, Mustapha Lkhider, Pascal Pineau, Rhimou Alaoui, Wafaa Badre, Sayeh Ezzikouri, Fatima-Zohra Fakhir

Publikováno v: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2016, 39, pp.141-146. ⟨10.1016/j.meegid.2016.01.023⟩
Infection, Genetics and Evolution, 2016, 39, pp.141-146. ⟨10.1016/j.meegid.2016.01.023⟩

Infection with Hepatitis C Virus (HCV) is one of the most important risk factor of hepatocellular carcinoma (HCC). HCV is suspected to induce HCC primarily through chronic inflammation and promotion of cirrhosis, a well-known pre-neoplastic condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5949c3681cfa274d17fca65e535c6d8
https://hal-pasteur.archives-ouvertes.fr/pasteur-02642751

Genetic variations in toll‐like receptors 7 and 8 modulate natural hepatitis C outcomes and liver disease progression.

Autor: Ezzikouri, Sayeh¹, Benjelloun, Soumaya¹, Fakhir, Fatima‐Zohra^1,2, Lkhider, Mustapha³, Badre, Wafaa⁴, Alaoui, Rhimou⁴, Meurs, Eliane F.⁵, Pineau, Pascal⁶

Publikováno v: Liver International. Mar2018, Vol. 38 Issue 3, p432-442. 11p. 3 Charts.

Development of Conformational Antibodies to Detect Bcl-xL's Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells.

Autor: Gonneaud, Alexis^1,2 (AUTHOR) alexis.gonneaud@usherbrooke.ca, Fakhir, Fatima-Zohra^1,3 (AUTHOR) fatimazohra.fakhir@gmail.com, Landas, Emeline¹ (AUTHOR) emeline66@hotmail.fr, Le Tallec, Enora¹ (AUTHOR) enora.letallec@yahoo.fr, Chartier-Garcia, Elisabeth¹ (AUTHOR) Elisabeth.CHARTIER-GARCIA@cea.fr, Almunia, Christine⁴ (AUTHOR) christine.almunia@cea.fr, Chenal, Alexandre⁵ (AUTHOR) alexandre.chenal@pasteur.fr, Forge, Vincent¹ (AUTHOR) vincent.forge@cea.fr, Marquette, Christel¹ (AUTHOR) christel.marquette@cea.fr

Publikováno v: International Journal of Molecular Sciences. Oct2020, Vol. 21 Issue 20, p7625-7625. 1p.