Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fatima-Zohra Braikia"'
Autor:
Yutthaphong Phongbunchoo, Fatima-Zohra Braikia, Cecilia Pessoa-Rodrigues, Senthilkumar Ramamoorthy, Haribaskar Ramachandran, Anna Grosschedl, Fei Ma, Pierre Cauchy, Asifa Akhtar, Ranjan Sen, Gerhard Mittler, Rudolf Grosschedl
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114456- (2024)
Summary: The rearrangement and expression of the immunoglobulin μ heavy chain (Igh) gene require communication of the intragenic Eμ and 3′ regulatory region (RR) enhancers with the variable (VH) gene promoter. Eμ binding of the transcription fac
Externí odkaz:
https://doaj.org/article/947821df47fa441d82f5564246d06fda
Autor:
Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Fatima-Zohra Braikia, Audrey Dauba, Frederick W. Alt, Ahmed Amine Khamlichi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin consta
Externí odkaz:
https://doaj.org/article/fb9a1a28118c4b5dabf5614e2b7d2067
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007930 (2019)
DNA cytosine methylation is involved in the regulation of gene expression during development and its deregulation is often associated with disease. Mammalian genomes are predominantly methylated at CpG dinucleotides. Unmethylated CpGs are often assoc
Externí odkaz:
https://doaj.org/article/0652176dc22b401e9a0253579a412352
Publikováno v:
Advances in immunology. 147
Class switch recombination (CSR) plays an important role in humoral immunity by generating antibodies with different effector functions. CSR to a particular antibody isotype is induced by external stimuli, and occurs between highly repetitive switch
Direct observation of RAG recombinase recruitment to chromatin and the IgH locus in live pro-B cells
Autor:
David G. Schatz, Zhe Liu, Amit Singh, Geoffrey A. Lovely, Fatima-Zohra Braikia, Ranjan Sen, Cornelis Murre
The RAG1 and RAG2 proteins introduce double-strand DNA breaks at antigen-receptor loci in developing lymphocytes to initiate V(D)J recombination. How RAG proteins find the correct target locus in a vast excess of non-specific chromatin is not known.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075fedddade6a8fd7836cd563a43266c
https://doi.org/10.1101/2020.09.07.286484
https://doi.org/10.1101/2020.09.07.286484
Autor:
Ranjan Sen, Fei Ma, Kevin G. Becker, Fatima Zohra Braikia, Michael L. Atchison, Xiang Qiu, Supriyo De, Mingming Zhao, William H. Wood, Angela Liu, Arun Dutta, Amit Singh, Hongkai Ji, Keji Zhao, Weiqiang Zhou, Lillian Shipp, Yaqiang Cao
Publikováno v:
Science Advances
Different mechanisms govern the first and second steps of IgH gene recombination.
Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG)
Immunoglobulin heavy chain (IgH) genes are assembled by two sequential DNA rearrangement events that are initiated by recombination activating gene products (RAG)
Publikováno v:
Cellular and molecular immunology
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2020, ⟨10.1038/s41423-020-0430-y⟩
Cell Mol Immunol
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2020, ⟨10.1038/s41423-020-0430-y⟩
Cell Mol Immunol
International audience; Class switch recombination (CSR) enables activated mature B cells to change immunoglobulin (Ig) isotype expression from IgM to IgG, IgE, or IgA. The process requires activation-induced cytidine deaminase (AID) expression and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a6b01761bc7049f8906772c2ec2f2f
https://hal.archives-ouvertes.fr/hal-03096510
https://hal.archives-ouvertes.fr/hal-03096510
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (7), pp.3553-3566. ⟨10.1093/nar/gkaa108⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (7), pp.3553-3566. ⟨10.1093/nar/gkaa108⟩
Developing B cells undergo V(D)J recombination to generate a vast repertoire of Ig molecules. V(D)J recombination is initiated by the RAG1/RAG2 complex in recombination centres (RCs), where gene segments become accessible to the complex. Whether tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee57fbf4da56767a28a3547ff54eb6a1
https://hal.archives-ouvertes.fr/hal-03428258
https://hal.archives-ouvertes.fr/hal-03428258
Publikováno v:
Advances in Immunology
Advances in Immunology, pp.89-137, 2020, ⟨10.1016/bs.ai.2020.06.003⟩
Advances in Immunology ISBN: 9780128207567
Advances in Immunology, pp.89-137, 2020, ⟨10.1016/bs.ai.2020.06.003⟩
Advances in Immunology ISBN: 9780128207567
Class switch recombination (CSR) plays an important role in humoral immunity by generating antibodies with different effector functions. CSR to a particular antibody isotype is induced by external stimuli, and occurs between highly repetitive switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144ea43400412a5a5bcbce0c2c784c26
https://hal.archives-ouvertes.fr/hal-03058984
https://hal.archives-ouvertes.fr/hal-03058984
Autor:
Joana M. Santos, Fatima-Zohra Braikia, Chloé Oudinet, Dania Haddad, Caroline Conte, Audrey Dauba, Ahmed Amine Khamlichi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
During an adaptive immune response, B cells can change their surface immunoglobulins from IgM to IgG, IgE or IgA through a process called class switch recombination (CSR). Switching is preceded by inducible non-coding germline transcription (GLT) of