Cytoprotective and Antioxidants in Peroxisomal Neurodegenerative Diseases

Autor: Mustapha Cherkaoui-Malki, Saad Shaaban, Mounia Tahri-Joutey, Ahmed Elshobaky, Fatima-Ezzahra Saih, Dominique Vervandier-Fasseur, Claus Jacob, Boubker Nasser, Norbert Latruffe, Pierre Andreoletti

Publikováno v: Proceedings, Vol 11, Iss 1, p 33 (2019)

Several of the peroxisomal neurodegenerative disorders are the consequence of a specific deficiency of an enzyme or a transporter involved in peroxisomal beta-oxidation of very long chain fatty acids [1,2]. One of the hallmarks in these peroxisomal r

Externí odkaz: https://doaj.org/article/bde9011027b443fca655154d567b83cd

Protective Effect of Nopal Cactus (

Autor: Mounia, Tahri-Joutey, Fatima-Ezzahra, Saih, Riad, El Kebbaj, Catherine, Gondcaille, Joseph, Vamecq, Norbert, Latruffe, Gérard, Lizard, Stéphane, Savary, Boubker, Nasser, Mustapha, Cherkaoui-Malki, Pierre, Andreoletti

Publikováno v: International journal of molecular sciences. 23(19)

Exposure to endotoxins (lipopolysaccharides, LPS) may lead to a potent inflammatory cytokine response and a severe impairment of metabolism, causing tissue injury. The protective effect provided by cactus seed oil (CSO), from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22673f514e2978015ec4a8c4111e7fa3
https://pubmed.ncbi.nlm.nih.gov/36233157

A microglial cell model for acyl-CoA oxidase 1 deficiency

Autor: Mustapha Cherkaoui-Malki, Michel Jadot, Stéphane Savary, Quentin Raas, Yannick Hamon, Catherine Gondcaille, Valerio Leoni, Claudio Caccia, Franck Ménétrier, Doriane Trompier, Boubker Nasser, Gérard Lizard, Pierre Andreoletti, Fatima-Ezzahra Saih

Publikováno v: Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2019, 1864 (4), pp.567-576. ⟨10.1016/j.bbalip.2018.10.005⟩

Acyl-CoA oxidase 1 (ACOX1) deficiency is a rare and severe peroxisomal leukodystrophy associated with a very long-chain fatty acid (VLCFA) β–oxidation defect. This neurodegenerative disease lacks relevant cell models to further decipher the pathom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6f3ecebeab89d9110a18d1ae1e300d
https://hal.archives-ouvertes.fr/hal-02359450

Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha)

Autor: Gérard Lizard, Hammam I. El Hajj, Norbert Latruffe, Pierre Andreoletti, Mustapha Cherkaoui-Malki, Fatima-Ezzahra Saih, Joseph Vamecq, Riad El Kebbaj, Boubker Nasser, Youssef El Kharrassi, M'Hammed Saïd El Kebbaj, Stéphane Mandard

Publikováno v: Biochimie Open
Biochimie Open, Elsevier, 2015, 1, pp.51-59. ⟨10.1016/j.biopen.2015.10.002⟩
Biochimie Open, 2015, 1, pp.51-59. ⟨10.1016/j.biopen.2015.10.002⟩
Biochimie Open, Vol 1, Iss C, Pp 51-59 (2015)
Biochimie Open, [Amsterdam] : Published by Elsevier B.V. on behalf of Société Française de Biochimie et Biologie Moléculaire (SFBBM), [2015]-, 2015, 1, pp.51-59. 〈10.1016/j.biopen.2015.10.002〉

In patients with sepsis, liver metabolism and its capacity to provide other organs with energetic substrates are impaired. This and many other pathophysiological changes seen in human patients are reproduced in mice injected with purified endotoxin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3b3dce7a010d7619ed5b7b1e2f9f7e
https://www.hal.inserm.fr/inserm-01534672/file/BiochimieOpen2015ElKebbaj.pdf