Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Fatima Z. Alshbool"'
Autor:
Precious O. Badejo MS, Shelby S. Umphres MS, Hamdy E.A. Ali PhD, Ahmed B. Alarabi PhD, Shahnaz Qadri PhD, Fatima Z. Alshbool PharmD, PhD, Fadi T. Khasawneh PhD
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics, Vol 29 (2024)
Introduction It is well documented that cardiovascular disease (CVD) is the leading cause of death in the US and worldwide, with smoking being the most preventable cause. Additionally, most smokers die from thrombotic-based diseases, in which platele
Externí odkaz:
https://doaj.org/article/f7dc5777d8f448b9967f930e7b47a039
Publikováno v:
BMC Medical Genomics, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract Corona virus disease 2019 (COVID-19) increases the risk of cardiovascular occlusive/thrombotic events and is linked to poor outcomes. The underlying pathophysiological processes are complex, and remain poorly understood. To this end, platele
Externí odkaz:
https://doaj.org/article/7ee678b66e40483da7964f657c7e5765
Autor:
Hamdy E.A. Ali, Ahmed B. Alarabi, Zubair A. Karim, Victor Rodriguez, Keziah R. Hernandez, Patricia A. Lozano, Medhat S. El-Halawany, Fatima Z. Alshbool, Fadi T. Khasawneh
Publikováno v:
Haematologica, Vol 107, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/f7192bd7816641b9ab25c6bb9326cc18
Autor:
Hanan Qasim, Ahmed B. Alarabi, Karem H. Alzoubi, Zubair A. Karim, Fatima Z. Alshbool, Fadi T. Khasawneh
Publikováno v:
Environmental Health and Preventive Medicine, Vol 24, Iss 1, Pp 1-17 (2019)
Abstract Hookah or waterpipe smoking or use is an emerging trend in the US population, especially among the youth. The misperception of hookah being less harmful than cigarettes and the availability of different but “appealing” flavors are consid
Externí odkaz:
https://doaj.org/article/1e292ccded184f2eb67cc63a7af8f8fa
Autor:
Yaoqiu Zhu, Elkin L. Romero, Xiaodong Ren, Angel J. Sanca, Congkuo Du, Cai Liu, Zubair A. Karim, Fatima Z. Alshbool, Fadi T. Khasawneh, Jiang Zhou, Dafang Zhong, Bin Geng
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to exis
Externí odkaz:
https://doaj.org/article/2a4a6cb750bb414987d1b5ebe5422517
Publikováno v:
Biochemistry and Biophysics Reports, Vol 20, Iss , Pp - (2019)
While changes in intracellular calcium levels is a central step in platelet activation and thrombus formation, the contribution and mechanism of receptor-operated calcium entry (ROCE) via transient receptor potential channels (TRPCs) in platelets rem
Externí odkaz:
https://doaj.org/article/63b7cd8332f6459cabd6178d6aa9273f
Autor:
Hanan Qasim, Zubair A. Karim, Keziah R. Hernandez, Dante Lozano, Fadi T. Khasawneh, Fatima Z. Alshbool
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 9 (2019)
Background Platelets are the cellular mediators of hemostasis and thrombosis, and their function is regulated by a number of molecular mediators, such as small GTPases. These small GTPases are themselves regulated by guanine nucleotide exchange facto
Externí odkaz:
https://doaj.org/article/f7c4a412e2b346aaa4508a318fca627f
Autor:
Keziah R. Hernandez, Zubair A. Karim, Hanan Qasim, Kirk M. Druey, Fatima Z. Alshbool, Fadi T. Khasawneh
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 5 (2019)
Background Members of the regulator of G‐protein signaling (RGS) family inhibit G‐protein coupled receptor signaling by modulating G‐protein activity. In platelets, there are 3 different RGS isoforms that are expressed at the protein level, inc
Externí odkaz:
https://doaj.org/article/a0e419a32f9f467791dfb9aa54f6684f
Autor:
Hanan Qasim, Zubair A. Karim, Juan C. Silva‐Espinoza, Fadi T. Khasawneh, José O. Rivera, Cameron C. Ellis, Stephanie L. Bauer, Igor C. Almeida, Fatima Z. Alshbool
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 15 (2018)
Background Cardiovascular disease is the main cause of death in the United States, with smoking being the primary preventable cause of premature death, and thrombosis being the main mechanism of cardiovascular mortality in smokers. Due to the percept
Externí odkaz:
https://doaj.org/article/c03b8dfd749f425da20bd5dc7661de86
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 13 (2018)
Background Despite the well‐established role for the thromboxane A2 receptor (TPR) in the development of thrombotic disorders, none of the antagonists developed to date has been approved for clinical use. To this end, we have previously shown that
Externí odkaz:
https://doaj.org/article/a31a68fdfc3d40128a0f28df7567e5e9