Toward MRI and Optical Detection of Zwitterionic Neurotransmitters: Near-Infrared Luminescent and Magnetic Properties of Macrocyclic Lanthanide(III) Complexes Appended with a Crown Ether and a Benzophenone Chromophore

Autor: Stéphane Petoud, Célia S. Bonnet, Éva Tóth, Matteo P. Placidi, Svetlana V. Eliseeva, Goran Angelovski, Fatima Oukhatar, Nikos K. Logothetis

Publikováno v: Inorganic Chemistry
Inorganic Chemistry, American Chemical Society, 2019, 58 (20), pp.13619-13630. ⟨10.1021/acs.inorgchem.9b00887⟩

International audience; Thanks to their versatile magnetic and luminescence features, lanthanide complexes have gained a central position in biomedical imaging as magnetic resonance imaging (MRI) contrast agents and optical imaging probes. In additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe0a7739ce787261a2fc462f06a7158
https://doi.org/10.1021/acs.inorgchem.9b00887

Straightforward and mild deprotection methods of N-mono- and N,N-functionalised bisaminal cyclens

Autor: Maryline Beyler, Raphaël Tripier, Fatima Oukhatar

Publikováno v: Tetrahedron. 71:3857-3862

Strategic removal of the bisaminal bridge of N-mono- and N1,N7-difunctionalised cyclen glyoxal derivatives was carried out via transamination processes with vicinal diamines. These procedures were found to be particularly well-suited for cyclen targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e751949b9dca00aa0735f36e66be36a
https://doi.org/10.1016/j.tet.2015.04.021

COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model

Autor: Martine Demeunynck, Catherine Ghezzi, M. Sallanon, Frank M. LaFerla, Dominique Garin, Danièle Marti-Battle, David Meyronet, Angélique Virgone-Carlotta, Michel Dubois-Dauphin, Pascale Perret, Philippe Millet, Bülent Gözel, Monique Touret, Sabine Chierici, Nathalie Streichenberger, Fatima Oukhatar

Publikováno v: Journal of Neurochemistry, Vol. 132 (2015) pp. 609-618
Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2015, 132 (5), pp.609-618. ⟨10.1111/jnc.12951⟩
Journal of Neurochemistry, 2015, 132 (5), pp.609-618. ⟨10.1111/jnc.12951⟩

International audience; Previous works have shown the interest of naturally fluorescent proflavine derivatives to label Abeta deposits in vitro. This study aimed to further characterize the properties of the proflavine 3-acetylamino-6-[3-(propargylam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdac4dfa130d403f1e5aef51652bd61
https://archive-ouverte.unige.ch/unige:92659

Proflavine derivatives as fluorescent imaging agents of amyloid deposits

Autor: M. Sallanon, Andrew B. Mahon, Martine Demeunynck, Fatima Oukhatar, Andrew C. Try, Sabine Chierici, Michel Dubois-Dauphin, Dominique Garin, Frank M. LaFerla

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21 (8), pp.2203-2206. ⟨10.1016/j.bmcl.2011.03.010⟩

A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23 months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f70152717c959eba2432dce5e332f9c
https://pubmed.ncbi.nlm.nih.gov/21435875

(1-Naphthyl)(trifluoromethyl) O-Carboxy Anhydride as a Chiral Derivatizing Agent: Eclipsed Conformation Enforced by Hydrogen Bonding.

Autor: Olivier Thillaye du Boullay, Aurélie Alba, Fatima Oukhatar, Blanca Martin-Vaca, Didier Bourissou

Publikováno v: Organic Letters; Sep2008, Vol. 10 Issue 20, p4669-4672, 4p