Multicentre randomised trial of screening with sFlt1/PlGF and planned delivery to prevent pre-eclampsia at term: protocol of the PE37 study

Autor: M Timmermans, Josefina Mora, Francesc Figueras, I Casas, H Castillo, Eduard Gratacos, Ladislav Krofta, Francesca Crovetto, Fatima Crispi, Carmina Comas, Alicia Martínez-Varea, Anna Kajdy, Elisa Llurba, Lina Youssef, Juan Luis Delgado, Isabel Puig, Katerina Mackova, Albert Tubau, Aina Ruiz, Antoni Paya, Maria Prat, Frederic Chantraine, Maria Fernanda Lopez-Tinajero, RJ Campos, V Parriego, D Sys, J Modzelewski

Publikováno v: BMJ Open, Vol 14, Iss 3 (2024)

Introduction Pre-eclampsia affects ~5%–7% of pregnancies. Although improved obstetric care has significantly diminished its associated maternal mortality, it remains a leading cause of maternal morbidity and mortality in the world. Term pre-eclamps

Externí odkaz: https://doaj.org/article/b0feffff59c3480cbca7e06ab8a6c120

Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

Autor: Chris Gale, Marian Knight, Kirsty Le Doare, Erica M Lokken, Laura A Magee, Peter von Dadelszen, Nathalie Broutet, Emily R Smith, Deborah Money, Stephanie Jones, Olof Stephansson, Lesley Regan, Fouzia Farooq, Christoph Lees, Julia Townson, Sami L Gottlieb, Jonas Söderling, Jorge Carrillo, Anna Thorson, Marleen Temmerman, Joyce Were, Edward Mullins, Ajay Reddy, Valerie J Flaherman, Clayton Onyango, Shabir A Madhi, Antonio Lanzone, Liona C Poon, Alice Panchaud, Musa Sekikubo, Eduard Gratacos, Renate Strehlau, Cande V. Ananth, Jorge E Tolosa, Justin S Brandt, Jennifer Hill, Erich Cosmi, Lauren Hookham, Raigam Jafet Martínez-Portilla, Francesca Crovetto, Fatima Crispi, Robert Mboizi, Jean B Nachega, Silvia Visentin, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A Tippett Barr, Elisa Bevilacqua, Irene Fernández Buhigas, Rebecca Clifton, Jeanne Conry, Camille Delgado-López, Hema Divakar, Amanda J Driscoll, Guillaume Favre, Maria M Gil, Olivia Hernandez, Erkan Kalafat, Sammy Khagayi, Karen Kotloff, Ethan Litman, Valentina Laurita Longo, Elizabeth M McClure, Tori D Metz, Emily S Miller, Sakita Moungmaithong, Marta C Nunes, Dickens Onyango, Daniel Raiten, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Miguel Valencia-Prado, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M Tielsch, Eduard Langenegger, Nadia A. Sam-Agudu, Onesmus W. Gachuno, Denis M. Mukwege, Richard Omore, Gregory Ouma, Kephas Otieno, Zacchaeus Abaja Were, Pinar Birol İlter, Federica Meli, Giulia Bonanni, Federica Romanzi, Eleonora Torcia, Chiara di Ilio, Haylea Sweat Patrick, Vuyelwa Baba, Mary Adam, Philiswa Mlandu, Yasmin Adam

Publikováno v: BMJ Global Health, Vol 8, Iss 1 (2023)

Introduction Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.Methods We screened ongoing studies in our sequen

Externí odkaz: https://doaj.org/article/212bea15d2284af082c33d055b991512

Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics

Autor: Lina Youssef, Jezid Miranda, Miquel Blasco, Cristina Paules, Francesca Crovetto, Marta Palomo, Sergi Torramade-Moix, Héctor García-Calderó, Olga Tura-Ceide, Ana Paula Dantas, Virginia Hernandez-Gea, Pol Herrero, Nuria Canela, Josep Maria Campistol, Joan Carles Garcia-Pagan, Maribel Diaz-Ricart, Eduard Gratacos, Fatima Crispi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Preeclampsia is a pregnancy-specific multisystem disorder and a leading cause of maternal and perinatal morbidity and mortality. The exact pathogenesis of this multifactorial disease remains poorly defined. We applied proteomics analysis on

Externí odkaz: https://doaj.org/article/03eced720d634700abc5b9b2c9e1e736

Evaluation of deep convolutional neural networks for automatic classification of common maternal fetal ultrasound planes

Autor: Xavier P. Burgos-Artizzu, David Coronado-Gutiérrez, Brenda Valenzuela-Alcaraz, Elisenda Bonet-Carne, Elisenda Eixarch, Fatima Crispi, Eduard Gratacós

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Abstract The goal of this study was to evaluate the maturity of current Deep Learning classification techniques for their application in a real maternal-fetal clinical environment. A large dataset of routinely acquired maternal-fetal screening ultras

Externí odkaz: https://doaj.org/article/58e62354554044beb548e7ef9d97b618

Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.

Autor: Lina Youssef, Lena Erlandsson, Bo Åkerström, Jezid Miranda, Cristina Paules, Francesca Crovetto, Fatima Crispi, Eduard Gratacos, Stefan R Hansson

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0239030 (2020)

Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes

Externí odkaz: https://doaj.org/article/45d7176e13f24d69a73ad9d2ff40b357