The clinical and molecular significance associated with STING signaling in breast cancer

Autor: Eileen E. Parkes, Matthew P. Humphries, Elaine Gilmore, Fatima A. Sidi, Victoria Bingham, Su M. Phyu, Stephanie Craig, Catherine Graham, Joseph Miller, Daryl Griffin, Manuel Salto-Tellez, Stephen F. Madden, Richard D. Kennedy, Samuel F. Bakhoum, Stephen McQuaid, Niamh E. Buckley

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)

Abstract STING signaling in cancer is a crucial component of response to immunotherapy and other anti-cancer treatments. Currently, there is no robust method of measuring STING activation in cancer. Here, we describe an immunohistochemistry-based ass

Externí odkaz: https://doaj.org/article/6790f073307d4fffbb5fb02a2f06cc1f

The clinical and molecular significance associated with STING signaling in breast cancer

Autor: Joseph Miller, Catherine Graham, Eileen Parkes, Daryl Griffin, Richard D Kennedy, Matthew P. Humphries, Elaine Gilmore, Stephanie G Craig, Victoria Bingham, Niamh E. Buckley, Stephen F. Madden, Manuel Salto-Tellez, Fatima Abdullahi Sidi, Samuel F. Bakhoum, Su M. Phyu, Stephen McQuaid

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)
Parkes, E E, Humphries, M P, Gilmore, E, Sidi, F A, Bingham, V, Phyu, S M, Craig, S, Graham, C, Miller, J, Griffin, D, Salto-Tellez, M, Madden, S, Kennedy, R D, Bakhoum, S F, McQuaid, S & Buckley, N E 2021, ' The clinical and molecular significance associated with STING signaling in breast cancer ', npj Breast Cancer, vol. 7, no. 1, 81 . https://doi.org/10.1038/s41523-021-00283-z, https://doi.org/10.1038/s41523-021-00283-z
NPJ Breast Cancer

STING signaling in cancer is a crucial component of response to immunotherapy and other anti-cancer treatments. Currently, there is no robust method of measuring STING activation in cancer. Here, we describe an immunohistochemistry-based assay with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a56dc702341e2a7afc39bfc3ef32192
https://doaj.org/article/6790f073307d4fffbb5fb02a2f06cc1f

The Potential of Digital Image Analysis to Determine Tumor Cell Content in Biobanked Formalin-Fixed, Paraffin-Embedded Tissue Samples

Autor: Christine Greene, Natalie C Fisher, Stephanie G Craig, Victoria Bingham, Matthew P. Humphries, Edwina O'Doherty, Claire Lewis, Fatima Abdullahi Sidi, Stephen McQuaid, Louise Harewood, Jacqueline James

Publikováno v: Greene, C, O'Doherty, E, Abdullahi Sidi, F, Bingham, V, Fisher, N, Humphries, M, Craig, S, Harewood, L, McQuaid, S, Lewis, C & James, J 2021, ' The Potential of Digital Image Analysis to Determine Tumor Cell Content in Biobanked Formalin-Fixed, Paraffin-Embedded Tissue Samples ', Biopreservation and Biobanking . https://doi.org/10.1089/bio.2020.0105

Introduction: Best practices dictate that biobanks ensure accurate determination of tumor content before supplying formalin-fixed, paraffin-embedded (FFPE) tissue samples to researchers for nucleic acid extraction and downstream molecular testing. It

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdf004cd4c5ba99960b5ed1cc63c7d6
https://pubmed.ncbi.nlm.nih.gov/33780631

Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization

Autor: Jacqueline James, Matthew P. Humphries, Stephen McQuaid, Stephanie G Craig, Manuel Salto-Tellez, Fatima Abdullahi Sidi, Victoria Bingham

Publikováno v: Cancers
Humphries, M P, Bingham, V, Abdullahi Sidi, F, Craig, S G, McQuaid, S, James, J & Salto-Tellez, M 2020, ' Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization ', Cancers, vol. 12, no. 5, 1114 . https://doi.org/10.3390/cancers12051114
Cancers, Vol 12, Iss 1114, p 1114 (2020)
Volume 12
Issue 5

Targeting of the programmed cell death protein (PD-1)/programmed death-ligand 1 (PD-L1) axis with checkpoint inhibitors has changed clinical practice in non-small cell lung cancer (NSCLC). However, clinical assessment remains complex and ambiguous. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e8e9bbbe488214ed9984ad52c8e212
https://pubmed.ncbi.nlm.nih.gov/32365629

Exponential Stability of Compactly Coupled Wave Equations with Delay Terms in the Boundary Feedbacks

Autor: Salah-Eddine Rebiai, Fatima Zohra Sidi Ali

Publikováno v: IFIP Advances in Information and Communication Technology ISBN: 9783662455036
System Modelling and Optimization

We consider a linear system of compactly coupled wave equations with Neumann feedback controllers that contain delay terms. First, we prove under some assumptions that the closed-loop system generates a \(C_{0}-\)semigroup of contractions on an appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3838af5a610395551369705f1e0a970
https://doi.org/10.1007/978-3-662-45504-3_27