Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Fatih Ozsolak"'
Autor:
Beltran Borges, Antonia Varthaliti, Marisa Schwab, Maria T. Clarke, Christopher Pivetti, Nalin Gupta, Cathryn R. Cadwell, Ghiabe Guibinga, Shirley Phillips, Tony Del Rio, Fatih Ozsolak, Denise Imai-Leonard, Lingling Kong, Diana J. Laird, Akos Herzeg, Charlotte J. Sumner, Tippi C. MacKenzie
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101263- (2024)
Prenatal somatic cell gene therapy (PSCGT) could potentially treat severe, early-onset genetic disorders such as spinal muscular atrophy (SMA) or muscular dystrophy. Given the approval of adeno-associated virus serotype 9 (AAV9) vectors in infants wi
Externí odkaz:
https://doaj.org/article/d01f9d171e174897be32403a75098f3a
Autor:
Francesco Ferrari, Annette Plachetka, Artyom A. Alekseyenko, Youngsook L. Jung, Fatih Ozsolak, Peter V. Kharchenko, Peter J. Park, Mitzi I. Kuroda
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 629-636 (2013)
Dosage compensation in Drosophila is mediated by the MSL complex, which increases male X-linked gene expression approximately 2-fold. The MSL complex preferentially binds the bodies of active genes on the male X, depositing H4K16ac with a 3′ bias.
Externí odkaz:
https://doaj.org/article/705d8554c552479baf25e2566c274e13
Autor:
Yuefeng Lin, Teresa T. Liu, Anne Dueck, Sang Woo Kim, A. Paula Monaghan, Gustavo Arango-Argoty, Fatih Ozsolak, Gunter Meister, Bino John, Zhihua Li, Donald B. DeFranco
Publikováno v:
RNA. 21:1159-1172
The highly conserved, multifunctional YB-1 is a powerful breast cancer prognostic indicator. We report on a pervasive role for YB-1 in which it associates with thousands of nonpolyadenylated short RNAs (shyRNAs) that are further processed into small
Publikováno v:
Cell. 156(4):812-824
SummaryWe measured half-lives of 21,248 mRNA 3′ isoforms in yeast by rapidly depleting RNA polymerase II from the nucleus and performing direct RNA sequencing throughout the decay process. Interestingly, half-lives of mRNA isoforms from the same ge
Autor:
Brinda Alagesan, Daniel A. Haber, Malgorzata E. Smas, David P. Ryan, Suchismita Paul, Gianmarco Contino, Nabeel Bardeesy, Min Yu, Brian W. Brannigan, Sridhar Ramaswamy, Fatih Ozsolak, Patrice M. Milos, Ben S. Wittner, Jordan C. Ciciliano, Mehmet Toner, David T. Ting, Daniel Winokur, Kristina Xega, Matthew J. Ulman, Anna J. Gilman, Lecia V. Sequist, Shannon L. Stott, Shyamala Maheswaran
Publikováno v:
Nature
Circulating tumour cells (CTCs) shed into blood from primary cancers include putative precursors that initiate distal metastases. Although these cells are extraordinarily rare, they may identify cellular pathways contributing to the blood-borne disse
Autor:
Fatih Ozsolak
Publikováno v:
Expert Opinion on Drug Discovery. 7:231-243
Introduction There is an immediate need for functional and molecular studies to decipher differences between disease and 'normal' settings to identify large quantities of validated targets with the highest therapeutic utilities. Furthermore, drug mec
Publikováno v:
The Prostate. 72:931-937
BACKGROUND Proliferative inflammatory atrophy (PIA) has been proposed as a potential precursor for prostate cancer. The precise molecular abnormalities in prostatic atrophy compared to high-grade prostatic intraepithelial neoplasia (HGPIN) and carcin
Autor:
Fatih Ozsolak, Patrice M. Milos
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 2:565-570
Methods for in-depth genome-wide characterization of transcriptomes and quantification of transcript levels using various microarray and next-generation sequencing technologies have emerged as valuable tools for understanding cellular physiology and
Autor:
Patrice M. Milos, Fatih Ozsolak
Publikováno v:
Nature Reviews Genetics. 12:87-98
In the few years since its initial application, massively parallel cDNA sequencing, or RNA-seq, has allowed many advances in the characterization and quantification of transcriptomes. Recently, several developments in RNA-seq methods have provided an
Autor:
Sang Woo Kim, Fatih Ozsolak, Bino John, A. Paula Monaghan, Elane Fishilevich, Patrice M. Milos, Philipp Kapranov, Sylvain Foissac
Publikováno v:
Cell
Cell, Elsevier, 2010, 143 (6), pp.1018-1029. ⟨10.1016/j.cell.2010.11.020⟩
Cell, Elsevier, 2010, 143 (6), pp.1018-1029. ⟨10.1016/j.cell.2010.11.020⟩
SummaryThe emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states. Here, we report comprehensive maps of global polyadenylation events in human and yeast