Zobrazeno 1 - 10
of 653
pro vyhledávání: '"Fatih M. Uckun"'
Autor:
Fatih M. Uckun, Sanjive Qazi
Publikováno v:
Onco, Vol 2, Iss 4, Pp 282-304 (2022)
Our main objective was to identify abundantly expressed tyrosine kinases in multiple myeloma (MM) as potential therapeutic targets. We first compared the transcriptomes of malignant plasma cells from newly diagnosed MM patients who were risk-categori
Externí odkaz:
https://doaj.org/article/fecaae7bb49249789bd2dc8382b09460
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/62318023434043dfb1e52b4e5561a978
Autor:
Fatih M. Uckun, Sanjive Qazi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9943 (2023)
The main goal of the present study was to examine if the RNA-sequencing (RNAseq)-based ERBB2/HER2 expression level in malignant plasma cells from multiple myeloma (MM) patients has clinical significance for treatment outcomes and survival. We examine
Externí odkaz:
https://doaj.org/article/8896895288694014a0d63f835c44b814
Autor:
Fatih M. Uckun, Cemal Orhan, Mehmet Tuzcu, Ali Said Durmus, Ibrahim H. Ozercan, Michael Volk, Kazim Sahin
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundWe recently reported the clinical safety profile of RJX, a well-defined intravenous GMP-grade pharmaceutical formulation of anti-oxidant and anti-inflammatory vitamins as active ingredients, in a Phase 1 study in healthy volunteers (Clinica
Externí odkaz:
https://doaj.org/article/d5d71df53e5645eda6a2339ec55cb731
Autor:
Justin Watts, Tara L. Lin, Alice Mims, Prapti Patel, Cynthia Lee, Anoush Shahidzadeh, Paul Shami, Elizabeth Cull, Christopher R. Cogle, Eunice Wang, Fatih M. Uckun
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
APVO436 is a recombinant bispecific antibody designed to direct host cytotoxic T-cells to CD123-expressing blast cells in patients with hematologic malignancies. APVO436 showed promising tolerability and single-agent activity in relapsed or refractor
Externí odkaz:
https://doaj.org/article/428b3dd5b7034e30953581d8a30b3ea9
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
IntroductionAfter the results of phase III vaccine studies became available, the leading oncology societies recommended two doses of COVID-19 vaccination to all patients with cancer with no specific recommendation for tumor type and active treatments
Externí odkaz:
https://doaj.org/article/f1dab24580d04d1cb62af92af96cee69
Autor:
Fatih M. Uckun
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Here we review the insights and lessons learned from early clinical trials of T-cell engaging bispecific antibodies (BsABs) as a new class of biotherapeutic drug candidates with clinical impact potential for the treatment of multiple myeloma (MM). Bs
Externí odkaz:
https://doaj.org/article/11695cf4ab3a40e68a0db44dd99e9bf0
Autor:
Fatih M. Uckun, Cemal Orhan, Joy Powell, Emre Sahin, Ibrahim H. Ozercan, Michael Volk, Kazim Sahin
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111823- (2021)
Here, we demonstrate that the two distinct formulations of our anti-sepsis drug candidate Rejuveinix (RJX), have a very favorable safety profile in Wistar Albino rats at dose levels comparable to the projected clinical dose levels. 14-day treatment w
Externí odkaz:
https://doaj.org/article/672581214b4b4751a3b6497f0705bd56
Autor:
Fatih M. Uckun, Justin Watts
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
There is an urgent need to identify effective strategies to prevent leukemic transformation and induce sustained deep remissions in adult high-risk myelodysplastic syndrome (MDS) patients. This article discusses the clinical impact potential of bispe
Externí odkaz:
https://doaj.org/article/d5567249eaab49bf9d5f0846d972ce92
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 612-620 (2019)
Recurrence of disease due to chemotherapy drug resistance remains a major obstacle to a more successful survival outcome of multiple myeloma (MM). Overcoming drug resistance and salvaging patients with relapsed and/or refractory (R/R) MM is an urgent
Externí odkaz:
https://doaj.org/article/a1fb9f8f72bd4cd3814c4e00bb7be4d5