Výsledky vyhledávání - "Fatih Ceteci"

Akademický článek

E-cadherin Controls Bronchiolar Progenitor Cells and Onset of Preneoplastic Lesions in Mice

Autor: Fatih Ceteci, Semra Ceteci, Emanuele Zanucco, Chitra Thakur, Matthias Becker, Nefertiti El-Nikhely, Ludger Fink, Werner Seeger, Rajkumar Savai, Ulf R. Rapp

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 12, Pp 1164-1177 (2012)

Although progenitor cells of the conducting airway have been spatially localized and some insights have been gained regarding their molecular phenotype, relatively little is known about the mechanisms regulating their maintenance, activation, and dif

Externí odkaz: https://doaj.org/article/fe7fcd8fdbf34d4db5bc4c7b76cfa3bb

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Akademický článek

Conditional Expression of Oncogenic C-RAF in Mouse Pulmonary Epithelial Cells Reveals Differential Tumorigenesis and Induction of Autophagy Leading to Tumor Regression

Autor: Fatih Ceteci, Jiajia Xu, Semra Ceteci, Emanuele Zanucco, Chitra Thakur, Ulf R. Rapp

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 11, Pp 1005-1018 (2011)

Here we describe a novel conditional mouse lung tumor model for investigation of the pathogenesis of human lung cancer. On the basis of the frequent involvement of the Ras-RAF-MEK-ERK signaling pathway in human non–small cell lung carcinoma (NSCLC)

Externí odkaz: https://doaj.org/article/0b8ca4e65b5c4498b04fc6e80e2232d0

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Akademický článek

Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.

Autor: Emanuele Zanucco, Rudolf Götz, Tamara Potapenko, Irene Carraretto, Semra Ceteci, Fatih Ceteci, Werner Seeger, Rajkumar Savai, Ulf R Rapp

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e29093 (2011)

Growth factor induced signaling cascades are key regulatory elements in tissue development, maintenance and regeneration. Perturbations of these cascades have severe consequences, leading to developmental disorders and neoplastic diseases. As a major

Externí odkaz: https://doaj.org/article/47f70ea4f9b04b58b8a63df0adffa01b

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Akademický článek

MYC is a metastasis gene for non-small-cell lung cancer.

Autor: Ulf R Rapp, Christian Korn, Fatih Ceteci, Christiaan Karreman, Katharina Luetkenhaus, Valentina Serafin, Emanuele Zanucco, Inês Castro, Tamara Potapenko

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e6029 (2009)

BACKGROUND:Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metasta

Externí odkaz: https://doaj.org/article/9eb5c357a57f4ff29956276e9848c329

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Akademický článek

Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer.

Autor: Matthias Becker, Christian Korn, Arnold R Sienerth, Robert Voswinckel, Katharina Luetkenhaus, Fatih Ceteci, Ulf R Rapp

Publikováno v: PLoS ONE, Vol 4, Iss 1, p e4230 (2009)

We have previously described a RAF oncogene driven transgenic mouse model for non small cell lung cancer (NSCLC). Here we examine whether tumor initiation and growth requires the stem cell self-renewal factor Bmi1.In order to evaluate Bmi1 function i

Externí odkaz: https://doaj.org/article/13158d7ea5a74b919d852c6308d2c948

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