Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fathima R. Kona"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 12, Pp 1379-1390 (2013)
Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administ
Externí odkaz:
https://doaj.org/article/bc0eb3b72a15435ab13de00f3b5a35d6
Autor:
Rahul Deshmukh, Daniela Buac, Bharati Mitra, Sara M. Schmitt, Christine Neslund-Dudas, Fathima R. Kona, Q. Ping Dou, Zhen Zhang, Min Shen
Publikováno v:
Current Pharmaceutical Design. 19:4025-4038
The cancer drug discovery field has placed much emphasis on the identification of novel and cancer-specific molecular targets. A rich source of such targets for the design of novel anti-tumor agents is the ubiqutin-proteasome system (UP-S), a tightly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51593a240a23318ca7a65ce922ce45d4
https://doi.org/10.2174/1381612811319220012
https://doi.org/10.2174/1381612811319220012
Publikováno v:
Breast Cancer Research and Treatment. 135:495-503
RNF115, or Breast Cancer-Associated Gene 2 (BCA2), encodes a RING-finger ubiquitin E3 ligase, expression of which was associated with estrogen receptor (ER)-positive status in human breast tumors. Although the BCA2 promoter contains several estrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d2533c67fab85cdcb33979ebb7328
https://doi.org/10.1007/s10549-012-2107-4
https://doi.org/10.1007/s10549-012-2107-4
Autor:
Fathima R. Kona, Andrea Brancale, Andrew D. Westwell, Ghali Brahemi, Angelika M Burger, Jitka Soukupova, Daniela Buac, Annalisa Fiasella
Publikováno v:
Journal of Medicinal Chemistry. 53:2757-2765
The zinc-ejecting aldehyde dehydrogenase (ALDH) inhibitory drug disulfiram (DSF) was found to be a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor activity. We herein describe our work in the synthesis and evaluation of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679796650337e2efe484223277b12e49
https://doi.org/10.1021/jm901757t
https://doi.org/10.1021/jm901757t
Publikováno v:
Biochemistry. 48:3610-3630
Aquifex aeolicus 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) is active with a variety of different divalent metal ions bound in the active site. The Cd{sup 2+}, Zn{sup 2+}, and Cu{sup 2+} substituted enzymes display similar values of k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63af3185e3c4b4c950b3539ae84a5c9e
https://doi.org/10.1021/bi801955h
https://doi.org/10.1021/bi801955h
Publikováno v:
Biochemistry. 46:4532-4544
There are two classes of KD08P synthases characterized respectively by the presence or absence of a metal in the active site. The nonmetallo KD08PS from Escherichia coli and the metallo KD08PS from Aquifex aeolicus are the best characterized members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48cddd44fac90dfb686c83b2f2a377a0
https://doi.org/10.1021/bi6024879
https://doi.org/10.1021/bi6024879
Publikováno v:
Recent Advances in Polyphenol Research, Volume 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::278f68d7d44db6a19bcd3f61c9dec4c7
https://doi.org/10.1002/9781118329634.ch7
https://doi.org/10.1002/9781118329634.ch7
Publikováno v:
Mini reviews in medicinal chemistry. 12(12)
Dithiocarbamates are a class of metal-chelating compounds with various applications in medicine. They have been used for the treatment of bacterial and fungal infections, possible treatment of AIDS, and most recently cancer. Their anti-tumor effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b465d9eabcec03a99d5eec9c23f0c1f1
https://pubmed.ncbi.nlm.nih.gov/22931591
https://pubmed.ncbi.nlm.nih.gov/22931591
Autor:
Arun Seth, Yuguang Gao, Stephanie Bacopulos, Fathima R. Kona, Yutaka Amemiya, Angelika M. Burger
Publikováno v:
The open cancer journal. 3(1)
The BCA2 protein contains a RING H2 finger and a Zn finger near the N-terminus and has E3 ligase activity. RING finger proteins play critical roles in mediating the transfer of ubiquitin and ubiquitin like modifiers to heterologous substrates as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b722572a6e2915e519b210e0b3a3b274
https://pubmed.ncbi.nlm.nih.gov/21179390
https://pubmed.ncbi.nlm.nih.gov/21179390
Publikováno v:
Current cancer drug targets. 11(3)
Disulfiram is a FDA approved drug for the treatment of alcoholism and available for clinical use since over 5 decades. Despite data from the 1970s and 80s that showed that disulfiram and analogs are able to enhance the activity of anticancer cytotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa0e5a39fc4e1d885597aea6593c7d5
https://pubmed.ncbi.nlm.nih.gov/21247383
https://pubmed.ncbi.nlm.nih.gov/21247383