Research of Pesticide Metabolites in Human Brain Tumor Tissues by Chemometrics-Based Gas Chromatography–Mass Spectrometry Analysis for a Hypothetical Correlation between Pesticide Exposure and Risk Factor of Central Nervous System Tumors

Autor: Kaouthar Louati, Fatma Kolsi, Rim Kallel, Yassine Gdoura, Mahdi Borni, Leila Sellami Hakim, Rania Zribi, Sirine Choura, Amina Maalej, Sami Sayadi, Mohamed Chamkha, Basma Mnif, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Fathi Safta

Publikováno v: ACS Omega, Vol 8, Iss 32, Pp 29812-29835 (2023)

Externí odkaz: https://doaj.org/article/ac02240c6b4646a599070b6029ceb422

Physical and chemical stability of cytarabine in polypropylene syringes

Autor: Myriam Razgallah Khrouf, Chema Drira, Mohamed Ali Soussi, Wiem Ben Ayed, Hanen Ouesleti, Ines Fradi, Fathi Safta, Besma Hamdene

Publikováno v: Journal of Oncology Pharmacy Practice. 27:827-833

Background Cytarabine is widely used to treat leukemia and lymphoma. Currently, Cyrabol®, powder for injection, is one of the specialties marketed in Tunisia. However, no stability data when diluted with 0.9% NaCl are available. The aim of this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a16efa78d64fce87dd9b4be5a3ef57
https://doi.org/10.1177/1078155220937405

Photodegradation of aqueous argatroban investigated by LC/MSn : Photoproducts, transformation processes and potential implications

Autor: Philippe-Henri Secrétan, Najet Yagoubi, Fathi Safta, Mélisande Bernard, Nour-Eddine Ghermani, Bernard Do, Maher Karoui

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 131:223-232

Argatroban (ARGA), used as intravenous anticoagulant drug, has been reported to photodegrade under light exposure, requiring specific precautions at handling, storage and administration. Thus, for the first time, aqueous ARGA photodegradation under a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7248f41e63aa9d74a1e6b01dcacfe738
https://doi.org/10.1016/j.jpba.2016.08.033

Use of mouse model in pharmacokinetic studies of poorly water soluble drugs: Application to fenofibrate

Autor: Nathalie Mignet, Badr Bahloul, Hélène Dhotel, Souad Sfar, Johanne Seguin, Fathi Safta, Mohamed Ali Lassoued

Publikováno v: Journal of Drug Delivery Science and Technology
Journal of Drug Delivery Science and Technology, Elsevier, 2018, 43, pp.149-153. ⟨10.1016/j.jddst.2017.10.006⟩
Journal of Drug Delivery Science and Technology, 2018, 43, pp.149-153. ⟨10.1016/j.jddst.2017.10.006⟩

International audience; Fenofibrate has recently been used as drug model in several studies with the objective of optimizing the development of some drug delivery systems to overcome the problem of poor aqueous solubility of the newly discovered API.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a2ec2f18e4141f70a9b64254f72b9e
https://hal.archives-ouvertes.fr/hal-03078844

An Integrated View of the Influence of Temperature, Pressure, and Humidity on the Stability of Trimorphic Cysteamine Hydrochloride

Autor: Ivo B. Rietveld, Carine Ghaddar, Bernard Do, Fathi Safta, Béatrice Nicolaï, Inès Gana, Maria Barrio, Josep-Lluís Tamarit

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname

Understanding the phase behavior of pharmaceuticals is important for dosage form development and regulatory requirements, in particular after the incident with ritonavir. In the present paper, a comprehensive study of the solid-state phase behavior o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c617e90ba265c2687c8f424167d3fdca
https://pubmed.ncbi.nlm.nih.gov/26042338