Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice

Autor: Faten Merhi-Soussi, Richard W. James, Christos Chadjichristos, David Magne, Marina Berti, François Mach, Graziano Pelli, Cem Gabay, Brenda R. Kwak

Publikováno v: Cardiovascular Research. 66:583-593

Objective : To examine the role of the balance between interleukin (IL)-1 and IL-1 receptor antagonist (IL-1Ra) in atherosclerosis and vascular inflammation. Methods : Transgenic (Tg) mice overexpressing either secreted IL-1Ra or intracellular IL-1Ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402e790ca068dca68c499d7abc0c7fc5
https://doi.org/10.1016/j.cardiores.2005.01.008

Mechanisms involved in the stimulation of prostacyclin synthesis by human lymphocytes in human umbilical vein endothelial cells

Autor: Michel Lagarde, Zury Domínguez, Olga Macovschi, Faten Merhi-Soussi, Annie-France Prigent, Georges Némoz, Madeleine Dubois

Publikováno v: British Journal of Pharmacology. 139:321-328

1 Endothelial cells play an important role in the modulation of vascular tone because of their ability to produce vasoactive substances such as prostacyclin (PGI(2)). Cell-cell contact between human umbilical vein endothelial cells (HUVEC) and periph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d556feea1620c6831c1515db2ee9db
https://doi.org/10.1038/sj.bjp.0705253

Endothelial cell prostacyclin synthesis induced by lymphocytes is independent of the membrane fatty acid composition of both cell types and of E-selectin, VCAM-1 or ICAM-1-mediated adhesion

Autor: Michel Lagarde, Zury Domínguez, Annie-France Prigent, Olga Macovschi, Georges Némoz, Faten Merhi-Soussi

Publikováno v: British Journal of Haematology. 113:521-532

Prostacyclin (PGI2), the main prostanoid in most vascular tissues regulates haemostasis and vascular tone, as well as the proliferation of smooth muscle cells. We have previously reported that lymphocyte contact with endothelium enhances endothelial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ad1417eb39cb1075b4b5bd8a2fcbac6
https://doi.org/10.1046/j.1365-2141.2001.02735.x

High salt intake abolishes AT2-mediated vasodilation of pial arterioles in rats

Autor: Faten Merhi-Soussi, François Dupuis, Isabelle Lartaud, Christine Capdeville-Atkinson, Yiu Wa Kwan, Caroline Perrin-Sarrado, Patrick Limiñana, Sébastien Foulquier, Katy Maguin Gaté, Jeffrey Atkinson

Publikováno v: Journal of Hypertension
Journal of Hypertension, Lippincott, Williams & Wilkins, 2011, 29 (7), pp.1392-1399. ⟨10.1097/HJH.0b013e328347050e⟩

International audience; Angiotensin II (Ang II) induces constriction (AT(1)) and dilation (AT(2) receptors) of cerebral arterioles. High sodium intake induces changes in receptors expression and loss of AT(2)-mediated vasodilation in extracerebral ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b532a2158052224b3021ca51ebbb5d6
https://hal.univ-lorraine.fr/hal-01646675

Platelets may inhibit leucotriene biosynthesis by human neutrophils at the integrin level

Autor: Bernard, Chabannes, Patrick, Moliere, Faten, Merhi-Soussi, Patrice E, Poubelle, Michel, Lagarde

Publikováno v: British journal of haematology. 121(2)

Polymorphonuclear leucocytes and blood platelets co-operate in several pathophysiological processes, and arachidonic acid (AA) metabolites produced in response to the activation of these cells are potent mediators of their functions. We studied the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45b02b7d1f67486e65dbee0d670962cb
https://pubmed.ncbi.nlm.nih.gov/12694258