Inhibition of NADPH oxidase alleviates germ cell apoptosis and ER stress during testicular ischemia reperfusion injury

Autor: Farah Khashab, May Al-Maghrebi, Nora Al-Kandari, Farah Al-Saleh, Fatemah Fadel

Publikováno v: Saudi Journal of Biological Sciences, Vol 27, Iss 8, Pp 2174-2184 (2020)
Saudi Journal of Biological Sciences

Testicular torsion and detorsion (TTD) is a serious urological condition affecting young males that is underlined by an ischemia reperfusion injury (tIRI) to the testis as the pathophysiological mechanism. During tIRI, uncontrolled production of oxyg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9b9c3762cf95184a4b635e3a70e69
http://www.sciencedirect.com/science/article/pii/S1319562X20301364

JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway

Autor: Farah Khashab, Farah Al-Saleh, Nora Al-Kandari, Fatemah Fadel, May Al-Maghrebi

Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13390
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13390, p 13390 (2021)

Testicular ischemia reperfusion injury (tIRI) causes oxidative stress-induced DNA damage leading to germ cell apoptosis (GCA). The aim of the study is to establish a direct link between JAK2 activation and the DNA damage response (DDR) signaling path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153bd3e634ac116b1e4faddb6bc5f807

Oxidative stress‐induced germ cell apoptosis: The NOX‐ER stress connection

Autor: May Al-Maghrebi, Farah Al-Saleh, Fatemah Fadel, Nora Al-Kandari, Farah Khashab

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ac91140fc4a5b3b84cd1045013bb497
https://doi.org/10.1096/fasebj.2020.34.s1.00524