Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Fatema A Legrand"'
1
Akademický článek
Use of a recombinant vaccinia virus expressing interferon gamma for post-exposure protection against vaccinia and ectromelia viruses.
Autor: Susan A Holechek, Karen L Denzler, Michael C Heck, Jill Schriewer, R Mark Buller, Fatema A Legrand, Paulo H Verardi, Leslie A Jones, Tilahun Yilma, Bertram L Jacobs
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77879 (2013)
Post-exposure vaccination with vaccinia virus (VACV) has been suggested to be effective in minimizing death if administered within four days of smallpox exposure. While there is anecdotal evidence for efficacy of post-exposure vaccination this has no
Externí odkaz: https://doaj.org/article/299781d8cc654d19aee1cd1f56066d3e
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2
Akademický článek
Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal.
Autor: Fatema A Legrand, Douglas F Nixon, Christopher P Loo, Erika Ono, Joan M Chapman, Maristela Miyamoto, Ricardo S Diaz, Amélia M N Santos, Regina C M Succi, Jacob Abadi, Michael G Rosenberg, Maria Isabel de Moraes-Pinto, Esper G Kallas
Publikováno v: PLoS ONE, Vol 1, p e102 (2006)
In utero transmission of HIV-1 occurs on average in only 3%-15% of HIV-1-exposed neonates born to mothers not on antiretroviral drug therapy. Thus, despite potential exposure, the majority of infants remain uninfected. Weak HIV-1-specific T-cell resp
Externí odkaz: https://doaj.org/article/92594db59ebe4db0aa87c0f3a3d8a362
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3
Akademický článek
Pan‐cancer population pharmacokinetics and exposure‐safety and ‐efficacy analyses of atezolizumab in patients with high tumor mutational burden
Autor: Colby S. Shemesh, Phyllis Chan, Fatema A. Legrand, David S. Shames, Meghna Das Thakur, Jane Shi, Lorna Bailey, Shweta Vadhavkar, Xian He, Wei Zhang, René Bruno
Publikováno v: Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
Abstract We retrospectively investigated the pharmacokinetics and exposure‐efficacy/safety relationships of single‐agent atezolizumab based on tissue tumor mutational burden (tTMB) status (high vs low [≥16 vs
Externí odkaz: https://doaj.org/article/e89b5559af7e4b42a15cf0069035da3c
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4
Pan‐cancer population pharmacokinetics and exposure‐safety and ‐efficacy analyses of atezolizumab in patients with high tumor mutational burden
Autor: Xian He, David S. Shames, Wei Zhang, Meghna Das Thakur, Jane Shi, Fatema A. Legrand, Phyllis Chan, Rene Bruno, Shweta Vadhavkar, Colby S. Shemesh, Lorna Bailey
Publikováno v: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
We retrospectively investigated the pharmacokinetics and exposure‐efficacy/safety relationships of single‐agent atezolizumab based on tissue tumor mutational burden (tTMB) status (high vs low [≥16 vs
In this work, we show that tissue tumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaef46a5a1f11e98be5800f765e79b9
http://europepmc.org/articles/PMC7689240
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6
IL-18 Expression Results in a Recombinant Vaccinia Virus That Is Highly Attenuated and Immunogenic
Autor: Kenneth S. Chan, Tilahun Yilma, Leslie A. Jones, Paulo H. Verardi, Fatema A. Legrand, Yue Peng
Publikováno v: Journal of Interferon & Cytokine Research. 34:169-178
Interferon-γ (IFN-γ) is an attenuating factor for vaccinia virus (VACV), decreasing its virulence in vivo by more than a million fold. It is also a highly effective adjuvant when administered at the time of immunization with protein antigens. Howev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891ead5115de3cbc1960c04d9a1882d0
https://doi.org/10.1089/jir.2013.0052
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9
Partial treatment interruption of protease inhibitors augments HIV-specific immune responses in vertically infected pediatric patients
Autor: Michael G. Rosenberg, Fatema A. Legrand, Douglas F. Nixon, Glenn J. Fennelly, Jacob Abadi, Kimberly A. Jordan, Steve Deeks, Andrew Wiznia, Miles P. Davenport
Publikováno v: AIDS. 19:1575-1585
Background: Although highly active antiretroviral therapy has significantly reduced morbidity and mortality in HIV-infected children, it often fails to completely suppress viral replication, thereby allowing the emergence of drug-resistant variants.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3e81fd2970c8f093e7f53f8cb83cb7
https://doi.org/10.1097/01.aids.0000186816.99993.8e
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10
Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus
Autor: Fatema A. Legrand, Kenneth S. Chan, Paulo H. Verardi, Tilahun Yilma
Publikováno v: Proceedings of the National Academy of Sciences. 102:8734-8739
The nef gene of human and simian immunodeficiency viruses (HIV and SIV) is important for pathogenicity and maintenance of high virus loads. We previously reported that recombinant vaccinia viruses (rVVs) expressing nef from attenuated SIVmac1A11 (vNe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53dbef41cc5f5a295716bdd4a87c1f3
https://doi.org/10.1073/pnas.0503542102
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