PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System

Autor: Jagan, Ishaan C., Deevi, Ravi K., Fatehullah, Aliya, Topley, Rebecca, Eves, Joshua, Stevenson, Michael, Loughrey, Maurice, Arthur, Kenneth, Campbell, Frederick Charles

Publikováno v: In Neoplasia November 2013 15(11):1218-1230

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Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype

Autor: Deevi, Ravi K., McClements, Jane, McCloskey, Karen D., Fatehullah, Aliya, Tkocz, Dorota, Javadi, Arman, Higginson, Robyn, Marsh Durban, Victoria, Jansen, Marnix, Clarke, Alan, Loughrey, Maurice B., Campbell, Frederick C.

Publikováno v: Deevi, R, McClements, J, McCloskey, K D, Fatehullah, A, Tkocz, D, Javadi, A, Higginson, R, Durban, V M, Jansen, M, Clarke, A, Loughrey, M & Campbell, F 2016, ' Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype ', Oncotarget, vol. 7, no. 31, pp. 49042-49064 . https://doi.org/10.18632/oncotarget.8863

Development of cribriform morphology (CM) heralds malignant change in human colon but lack of mechanistic understanding hampers preventive therapy. This study investigated CM pathobiology in three-dimensional (3D) Caco-2 culture models of colorectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d72172dac23051de3f5103220d735a02
https://pure.qub.ac.uk/en/publications/vitamin-d3-suppresses-morphological-evolution-of-the-cribriform-cancerous-phenotype(bc46a215-7aa6-4f6b-b2b9-ca00342eb4b5).html

PTEN Phosphatase-Independent Maintenance of Glandular Morphology in a Predictive Colorectal Cancer Model System1

Autor: Jagan, Ishaan C, Deevi, Ravi K, Fatehullah, Aliya, Topley, Rebecca, Eves, Joshua, Stevenson, Michael, Loughrey, Maurice, Arthur, Kenneth, Campbell, Frederick Charles

Organotypic models may provide mechanistic insight into colorectal cancer (CRC) morphology. Three-dimensional (3D) colorectal gland formation is regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN) coupling of cell division c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1db6ff2cde351a1aa713dde5cde63f8e
https://europepmc.org/articles/PMC3858899/

Organoids as an in vitro model of human development and disease.

Autor: Fatehullah A; A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore., Tan SH; A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore., Barker N; A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.; Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4TJ, UK.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.

Publikováno v: Nature cell biology [Nat Cell Biol] 2016 Mar; Vol. 18 (3), pp. 246-54.