Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Fasiczka, A."'
Autor:
Lucia Iannotta, Rachel Fasiczka, Giulia Favetta, Yibo Zhao, Elena Giusto, Elena Dall’Ara, Jianning Wei, Franz Y. Ho, Claudia Ciriani, Susanna Cogo, Isabella Tessari, Ciro Iaccarino, Maxime Liberelle, Luigi Bubacco, Jean-Marc Taymans, Claudia Manzoni, Arjan Kortholt, Laura Civiero, Sabine Hilfiker, Michael L. Lu, Elisa Greggio
Publikováno v:
Cell Death and Disease, Vol 15, Iss 10, Pp 1-14 (2024)
Abstract P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the physi
Externí odkaz:
https://doaj.org/article/795a4c0f9a0e410b87c1129fe09b26ab
Autor:
Yahaira Naaldijk, Belén Fernández, Rachel Fasiczka, Elena Fdez, Coline Leghay, Ioana Croitoru, John B. Kwok, Yanisse Boulesnane, Amelie Vizeneux, Eugenie Mutez, Camille Calvez, Alain Destée, Jean-Marc Taymans, Ana Vinagre Aragon, Alberto Bergareche Yarza, Shalini Padmanabhan, Mario Delgado, Roy N. Alcalay, Zac Chatterton, Nicolas Dzamko, Glenda Halliday, Javier Ruiz-Martínez, Marie-Christine Chartier-Harlin, Sabine Hilfiker
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Parkinson´s disease (PD) is a common neurodegenerative movement disorder and leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention. However, the ability to stratify patients who will benefit from su
Externí odkaz:
https://doaj.org/article/c64a6d54ee0f438bada89215f582520b
Autor:
Fasiczka, Rachel, Hilfiker, Sabine
Publikováno v:
In Trends in Neurosciences January 2024 47(1):1-3
Autor:
Fdez, Elena, Madero-Pérez, Jesús, Lara Ordóñez, Antonio J., Naaldijk, Yahaira, Fasiczka, Rachel, Aiastui, Ana, Ruiz-Martínez, Javier, López de Munain, Adolfo, Cowley, Sally A., Wade-Martins, Richard, Hilfiker, Sabine
Publikováno v:
In iScience 17 June 2022 25(6)
Autor:
Iannotta, Lucia, Fasiczka, Rachel, Favetta, Giulia, Zhao, Yibo, Giusto, Elena, Dall'Ara, Elena, Wei, Jianning, Ho, Franz Y., Ciriani, Claudia, Cogo, Susanna, Tessari, Isabella, Iaccarino, Ciro, Liberelle, Maxime, Bubacco, Luigi, Taymans, Jean-Marc, Manzoni, Claudia, Kortholt, Arjan, Civiero, Laura, Hilfiker, Sabine, Lu, Michael L.
Publikováno v:
Cell Death & Disease; Oct2024, Vol. 15 Issue 10, p1-14, 14p
Autor:
Elena Fdez, Rachel Fasiczka, Antonio Jesús Lara Ordóñez, Belén Fernández, Yahaira Naaldijk, Sabine Hilfiker
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102024- (2023)
Summary: The present protocol allows for quantification of inter-centrosome distances in G2 phase cells by confocal fluorescence microscopy to determine centrosome cohesion deficits. We describe transfection and immunofluorescence approaches followed
Externí odkaz:
https://doaj.org/article/04f2dbe9b5994765ae1cecc88504de5b
Autor:
Antonio Jesús Lara Ordóñez, Rachel Fasiczka, Belén Fernández, Yahaira Naaldijk, Elena Fdez, Marian Blanca Ramírez, Sébastien Phan, Daniela Boassa, Sabine Hilfiker
Publikováno v:
Biology Open, Vol 11, Iss 8 (2022)
The Parkinson's-disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and
Externí odkaz:
https://doaj.org/article/8cb254396df94dd693b6592040ef9931
Autor:
Elena Fdez, Jesús Madero-Pérez, Antonio J. Lara Ordóñez, Yahaira Naaldijk, Rachel Fasiczka, Ana Aiastui, Javier Ruiz-Martínez, Adolfo López de Munain, Sally A. Cowley, Richard Wade-Martins, Sabine Hilfiker
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104476- (2022)
Summary: Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1. The phospho-Rab/RILPL1 interaction causes deficits in ciliogenesis and int
Externí odkaz:
https://doaj.org/article/3d22d94d6d3d44799ee321641eb2a4fb
Akademický článek
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Autor:
Alexander, Krista K., Naaldijk, Yahaira, Fasiczka, Rachel, Brahmia, Besma, Chen, Tiancheng, Hilfiker, Sabine, Kennedy, Eileen J.
Publikováno v:
Journal of Peptide Science; May2024, Vol. 30 Issue 5, p1-12, 12p