Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Farzin Gharahdaghi"'
Autor:
Garrett W Rhyasen, Yi Yao, Jingwen Zhang, Austin Dulak, Lillian Castriotta, Kelly Jacques, Wei Zhao, Farzin Gharahdaghi, Maureen M Hattersley, Paul D Lyne, Edwin Clark, Michael Zinda, Stephen E Fawell, Gordon B Mills, Huawei Chen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200826 (2018)
BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications. Despite previously de
Externí odkaz:
https://doaj.org/article/8462634de4fc494185365ef6a8d1e6ce
Autor:
Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang
PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72f443eea55562ffa6cc913b43229d
https://doi.org/10.1158/0008-5472.c.6510161.v1
https://doi.org/10.1158/0008-5472.c.6510161.v1
Autor:
Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang
Supplemental materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c90f8ab65849ea462ef14da7c54638
https://doi.org/10.1158/0008-5472.22418558.v1
https://doi.org/10.1158/0008-5472.22418558.v1
Autor:
Michele Mayo, Tony Cheung, Jiaquan Wu, Nancy Su, Xin Wang, Dan Widzowski, Jeffrey W. Johannes, Michelle Lamb, Keith Mikule, Corinne Reimer, Paul Lyne, Shaun E. Grosskurth, Ryan T. Howard, Stephen Fawell, Jingwen Zhang, Edward W. Tate, Philip Petteruti, Huawei Chen, Michael Zinda, Scott David, Deborah Lawson, Farzin Gharahdaghi, Wenxian Wang, Jonathan R. Dry, Zebin Wang
PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c41fd9f1d0989c85eba69777dc61354
http://hdl.handle.net/10044/1/64761
http://hdl.handle.net/10044/1/64761
Autor:
Kelly Jacques, Michael Zinda, Gordon B. Mills, Lillian Castriotta, Farzin Gharahdaghi, Edwin Clark, Stephen Fawell, Wei Zhao, Garrett W. Rhyasen, Austin Dulak, Huawei Chen, Jingwen Zhang, Yi Yao, Paul Lyne, Maureen Hattersley
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200826 (2018)
PLoS ONE
PLoS ONE
BRD4 is a transcriptional co-activator functioning to recruit regulatory complexes to acetylated chromatin. A subset of High-grade Serous Ovarian Cancer (HGSOC) patients are typified by focal, recurrent BRD4 gene amplifications. Despite previously de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b0b1f8090e2e9c2f66057f9edb0ad2
http://europepmc.org/articles/PMC6056044?pdf=render
http://europepmc.org/articles/PMC6056044?pdf=render
Autor:
Adam Jeston Dudley, Joanne Smolka, Carla Maciag, Chapdelaine Marc, Michael Quirk, Wei Song, Farzin Gharahdaghi, Xiaodong F. Liu, Maria Ribadeneira, Donna L. Maier, Jeffrey L. Arriza, Dean H. Snyder, James J. Doherty, Maninder Chopra, Min Ding, David Gurley, Edward P. Christian
Publikováno v:
Journal of Neurophysiology. 113:116-131
Benzodiazepine drugs, through interaction with GABAAα1, GABAAα2,3, and GABAAα5 subunits, modulate cortical network oscillations, as reflected by a complex signature in the EEG power spectrum. Recent drug discovery efforts have developed GABAAα2,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b230ce60a550bef457160844275d07
https://doi.org/10.1152/jn.00539.2013
https://doi.org/10.1152/jn.00539.2013
Autor:
Xiahui Zhu, Farzin Gharahdaghi, Bin Yang, Michelle Lamb, Wenxian Wang, Keith Mikule, Claudio Chuaqui, Philip Petteruti, Nancy Su, Kelly Jacques, Zhongwu Lai, Jiaquan Wu, Huawei Chen, Nicholas Keen, Erin Code
Publikováno v:
ACS Chemical Biology. 8:2201-2208
Centrosome amplification is observed in many human cancers and has been proposed to be a driver of both genetic instability and tumorigenesis. Cancer cells have evolved mechanisms to bundle multiple centrosomes into two spindle poles to avoid multipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb15b1358622c15a571173f1750f456e
https://doi.org/10.1021/cb400186w
https://doi.org/10.1021/cb400186w
Publikováno v:
Analytical Biochemistry. 233:94-99
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in conjunction with enzymatic digestion of proteins and molecular weight search of peptide-mass database is a powerful technique for peptide/protein identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9316a72b73cbc93ce754f8fe8ded0862
https://doi.org/10.1006/abio.1996.0012
https://doi.org/10.1006/abio.1996.0012
Autor:
Farzin Gharahdaghi, Xincai Luo, Euan Gordon, Dee E. Wilkins, Kathy A. Paschetto, Gaochao Tian, Clay W Scott
Publikováno v:
Biochemistry. 50(32)
Fatty acid amide hydrolase (FAAH) has emerged as a potential target for developing analgesic, anxiolytic, antidepressant, sleep-enhancing, and anti-inflammatory drugs, and tremendous efforts have been made to discover potent and selective inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de86d544c605847d0b7b9d1c576b8a1e
https://pubmed.ncbi.nlm.nih.gov/21728345
https://pubmed.ncbi.nlm.nih.gov/21728345
Publikováno v:
Electrophoresis. 19(6)
As the resource laboratory for Rockefeller University our emphasis continues to be on methodology development for the routine analysis of low abundance proteins isolated from native sources. In the past ten years, gel electrophoresis of proteins has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a8f6469faabc964a6ea7ca4daeb242
https://pubmed.ncbi.nlm.nih.gov/9638950
https://pubmed.ncbi.nlm.nih.gov/9638950