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of 2
pro vyhledávání: '"Farzaneh S. Mirfakhar"'
Autor:
Catarina Perdigão, Mariana A. Barata, Margarida N. Araújo, Farzaneh S. Mirfakhar, Jorge Castanheira, Cláudia Guimas Almeida
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease p
Externí odkaz:
https://doaj.org/article/e4313ce9df324ed993478f2ff5c9f6e3
Autor:
Fabia Filipello, Shih-Feng You, Farzaneh S. Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A. Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A. Minaya, Arun Renganathan, Anil G. Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K. Iyer, Marina Cella, Wendy H. Raskind, Laura Piccio, Celeste M. Karch
Publikováno v:
Acta Neuropathologica. 145:749-772
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer’s disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukody