Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Faruk Sinangil"'
Autor:
Kombo F. N’guessan, Kawthar Machmach, Isabella Swafford, Margaret C. Costanzo, Lindsay Wieczorek, Dohoon Kim, Siriwat Akapirat, Victoria R. Polonis, Punnee Pitisuttithum, Sorachai Nitayaphan, Sanjay Gurunathan, Faruk Sinangil, Suwat Chariyalertsak, Julie A. Ake, Robert J. O’connell, Sandhya Vasan, Dominic Paquin-Proulx
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The RV144 Thai phase III clinical trial’s canarypox–protein HIV vaccine regimen showed modest efficacy in reducing infection. We therefore sought to determine the effects of vaccine administration on innate cell activation and subsequent associat
Externí odkaz:
https://doaj.org/article/b63b37f19fa546188d5104a25d963234
Autor:
Giovanna Meza, Fátima Galián, Claudia Jaimes-Bernal, Francisco J. Márquez, Faruk Sinangil, Carolina Scagnolari, Luis Miguel Real, Donald Forthal, Antonio Caruz
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 757-763 (2022)
Individuals lacking interferon lambda 4 (IFNL4) protein due to a common null mutation (rs368234815) in the IFNL4 gene display higher resistance against several infections. The influence of IFNL4 on HIV-1 infection is still under discussion and confli
Externí odkaz:
https://doaj.org/article/00b7370b2c734f5c8ba4f9b9e3ddf925
Autor:
Margaret C. Costanzo, Dominic Paquin-Proulx, Alexandra Schuetz, Siriwat Akapirat, Zhanna Shubin, Dohoon Kim, Lindsay Wieczorek, Victoria R. Polonis, Hung V. Trinh, Mangala Rao, Hanna Anenia, Michael D. Barrera, Jacob Boeckelman, Barbara Nails, Pallavi Thapa, Michelle Zemil, Carlo Sacdalan, Eugene Kroon, Boot Kaewboon, Somporn Tipsuk, Surat Jongrakthaitae, Sanjay Gurunathan, Faruk Sinangil, Jerome H. Kim, Merlin L. Robb, Julie A. Ake, Robert J. O’Connell, Punnee Pitisutthithum, Sorachai Nitayaphan, Suwat Chariyalertsak, Michael A. Eller, Nittaya Phanuphak, Sandhya Vasan, the RV, RV328 study groups
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
The RV144 phase III vaccine trial demonstrated that ALVAC-HIV and AIDSVAX B/E administration over 6 months resulted in 31% efficacy in preventing HIV acquisition, while administration of AIDSVAX B/E alone in both VAX003 and VAX004 studies failed to s
Externí odkaz:
https://doaj.org/article/54ea0fbbfd224eb79d9efe0dfded1c6a
Autor:
Kathryn A Mesa, Bin Yu, Terri Wrin, Christos J Petropoulos, Grant H Pogson, David L Alexander, Gerardo Perez, Sara M O'Rourke, Faruk Sinangil, Joseph Robinson, Marcus A Conant, Phillip W Berman
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0213409 (2019)
A major challenge in HIV vaccine development is the identification of immunogens able to elicit broadly neutralizing antibodies (bNAbs). While remarkable progress has been made in the isolation and characterization of bNAbs, the epitopes they recogni
Externí odkaz:
https://doaj.org/article/0e10722cf3d44aa2bd12c97c8f7b22f2
Autor:
Siriwat Akapirat, Chitraporn Karnasuta, Sandhya Vasan, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sirinan Madnote, Hathairat Savadsuk, Surawach Rittiroongrad, Jiraporn Puangkaew, Sanjay Phogat, James Tartaglia, Faruk Sinangil, Mark S de Souza, Jean-Louis Excler, Jerome H Kim, Merlin L Robb, Nelson L Michael, Viseth Ngauy, Robert J O'Connell, Nicos Karasavvas, RV305 Study Group
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196397 (2018)
Sexual transmission is the principal driver of the human immunodeficiency virus (HIV) pandemic. Understanding HIV vaccine-induced immune responses at mucosal surfaces can generate hypotheses regarding mechanisms of protection, and may influence vacci
Externí odkaz:
https://doaj.org/article/b6a6cce028b540d6b3b05c44c133477e
Autor:
David Easterhoff, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O Saunders, Justin Pollara, Nathan Vandergrift, Rob Parks, Jerome Kim, Nelson L Michael, Robert J O'Connell, Jean-Louis Excler, Merlin L Robb, Sandhya Vasan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, Sorachai Nitayaphan, Faruk Sinangil, James Tartaglia, Sanjay Phogat, Thomas B Kepler, S Munir Alam, Hua-Xin Liao, Guido Ferrari, Michael S Seaman, David C Montefiori, Georgia D Tomaras, Stephen C Harrison, Barton F Haynes
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006182 (2017)
The canary pox vector and gp120 vaccine (ALVAC-HIV and AIDSVAX B/E gp120) in the RV144 HIV-1 vaccine trial conferred an estimated 31% vaccine efficacy. Although the vaccine Env AE.A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broa
Externí odkaz:
https://doaj.org/article/ac77c8a72fe944fc9406e5f67c47cb34
Autor:
Lautaro G Perez, David R Martinez, Allan C deCamp, Abraham Pinter, Phillip W Berman, Donald Francis, Faruk Sinangil, Carter Lee, Kelli Greene, Hongmei Gao, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Robert J O'Connell, Merlin L Robb, Nelson L Michael, Jerome H Kim, Peter Gilbert, David C Montefiori
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180720 (2017)
Non-neutralizing IgG to the V1V2 loop of HIV-1 gp120 correlates with a decreased risk of HIV-1 infection but the mechanism of protection remains unknown. This V1V2 IgG correlate was identified in RV144 Thai trial vaccine recipients, who were primed w
Externí odkaz:
https://doaj.org/article/c36ea6f861184e5d9675e59626f76437
Autor:
Peter B Gilbert, Jean-Louis Excler, Georgia D Tomaras, Lindsay N Carpp, Barton F Haynes, Hua-Xin Liao, David C Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H Kijak, Sodsai Tovanabutra, Donald P Francis, Carter Lee, Faruk Sinangil, Phillip W Berman, Nakorn Premsri, Prayura Kunasol, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Rhoda Morrow, Lawrence Corey, Jerome H Kim
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176428 (2017)
BACKGROUND:In the HIV-1 vaccine trial RV144, ALVAC-HIV prime with an AIDSVAX® B/E boost reduced HIV-1 acquisition by 31% at 42 months post first vaccination. The bivalent AIDSVAX® B/E vaccine contains two gp120 envelope glycoproteins, one from the
Externí odkaz:
https://doaj.org/article/749ab0ed603a4682a6678cef9d673819
Autor:
Raphael Gottardo, Robert T Bailer, Bette T Korber, S Gnanakaran, Joshua Phillips, Xiaoying Shen, Georgia D Tomaras, Ellen Turk, Gregory Imholte, Larry Eckler, Holger Wenschuh, Johannes Zerweck, Kelli Greene, Hongmei Gao, Phillip W Berman, Donald Francis, Faruk Sinangil, Carter Lee, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Jaranit Kaewkungwal, Punnee Pitisuttithum, James Tartaglia, Merlin L Robb, Nelson L Michael, Jerome H Kim, Susan Zolla-Pazner, Barton F Haynes, John R Mascola, Steve Self, Peter Gilbert, David C Montefiori
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75665 (2013)
Neutralizing and non-neutralizing antibodies to linear epitopes on HIV-1 envelope glycoproteins have potential to mediate antiviral effector functions that could be beneficial to vaccine-induced protection. Here, plasma IgG responses were assessed in
Externí odkaz:
https://doaj.org/article/df8c4ccdd54e4bd9aaaede24511613f5
Autor:
Marcos Pérez-Losada, David V Jobes, Faruk Sinangil, Keith A Crandall, Miguel Arenas, David Posada, Phillip W Berman
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e16902 (2011)
In 2003, a phase III placebo-controlled trial (VAX003) was completed in Bangkok, Thailand. Of the 2,546 individuals enrolled in the trial based on high risk for infection through injection drug use (IDU), we obtained clinical samples and HIV-1 sequen
Externí odkaz:
https://doaj.org/article/d64cbcc6c854469bb99cd4b7a75d19a5