Zobrazeno 1 - 10
of 583
pro vyhledávání: '"Farshid Guilak"'
Autor:
Niek G. C. Bloks, Amanda Dicks, Zainab Harissa, Rob G. H. H. Nelissen, Ghazaleh Hajmousa, Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, Farshid Guilak, Ingrid Meulenbelt
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain, and a significant decrease in quality of life. Among other risk factors,
Externí odkaz:
https://doaj.org/article/709c5477d58844cfa4f24af6d4e8ead4
Autor:
Niek GC Bloks, Zainab Harissa, Giorgia Mazzini, Shaunak S Adkar, Amanda R Dicks, Ghazaleh Hajmousa, Nancy Steward, Roman I. Koning, Aat Mulder, Berend B.R. deKoning, Margreet Kloppenburg, Rodrigo Coutinho deAlmeida, Yolande FM Ramos, Farshid Guilak, Ingrid Meulenbelt
Publikováno v:
Advanced Science, Vol 11, Iss 36, Pp n/a-n/a (2024)
Abstract The pericellular matrix (PCM), with its hallmark proteins collagen type VI (COLVI) and fibronectin (FN), surrounds chondrocytes and is critical in transducing the biomechanical cues. To identify genetic variants that change protein function,
Externí odkaz:
https://doaj.org/article/499b44c7a24a45fda0ef7e6416b47f61
Autor:
James Melrose, Farshid Guilak
Publikováno v:
JOR Spine, Vol 7, Iss 3, Pp n/a-n/a (2024)
Abstract Perlecan is a widely distributed, modular, and multifunctional heparan sulfate proteoglycan, which facilitates cellular communication with the extracellular environment to promote tissue development, tissue homeostasis, and optimization of b
Externí odkaz:
https://doaj.org/article/b6485dc79f264872b9441eda92794083
Autor:
Michal Dudek, Dharshika R. J. Pathiranage, Beatriz Bano-Otalora, Anna Paszek, Natalie Rogers, Cátia F. Gonçalves, Craig Lawless, Dong Wang, Zhuojing Luo, Liu Yang, Farshid Guilak, Judith A. Hoyland, Qing-Jun Meng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator circadian system entrained through environmental cues (e.g. light and feeding). The presence of tissue niche-dependent physiological time cues has been p
Externí odkaz:
https://doaj.org/article/9e210009537f41aeac826a1fa19c039e
Publikováno v:
JOR Spine, Vol 6, Iss 4, Pp n/a-n/a (2023)
Abstract Background The ion channel transient receptor potential vanilloid 4 (TRPV4) critically transduces mechanical forces in the IVD, and its inhibition can prevent IVD degeneration due to static overloading. However, it remains unknown whether di
Externí odkaz:
https://doaj.org/article/a079bb713e43442380654a2c6a68a239
Autor:
Amanda R Dicks, Grigory I Maksaev, Zainab Harissa, Alireza Savadipour, Ruhang Tang, Nancy Steward, Wolfgang Liedtke, Colin G Nichols, Chia-Lung Wu, Farshid Guilak
Publikováno v:
eLife, Vol 12 (2023)
Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we use CRISPR-Cas9-edited human-induced pluripotent stem cells (hi
Externí odkaz:
https://doaj.org/article/4223b454adbc4d21a9b6aaa05a607eef
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Lipodystrophic mice are protected from cartilage damage following joint injury. This protection can be reversed by the implantation of a small adipose tissue graft. The purpose of this study was to evaluate the relationship between the gut m
Externí odkaz:
https://doaj.org/article/29153d110d634d57a3f3d4e6d8a19042
Autor:
Cristóbal López-Jiménez, Loraine L.Y. Chiu, Stephen D. Waldman, Farshid Guilak, Thomas G. Koch
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 2, Pp 100263- (2022)
Objective: To evaluate the effect of Transient Receptor Potential Vanilloid 4 (TRPV4) cation channel modulation on mesenchymal stromal cell (MSC)-derived neocartilage. Methods: RT-PCR was performed to evaluate mRNA levels of chondrogenic, hypertrophi
Externí odkaz:
https://doaj.org/article/cad3083abb58407aa0f7b6cb6e187aec
Autor:
Katherine R. Hixon, Dakota B. Katz, Jennifer A. McKenzie, Anna N. Miller, Farshid Guilak, Matthew J. Silva
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Non-union is defined as the permanent failure of a bone to heal and occurs clinically in 5% of fractures. Atrophic non-unions, characterized by absent/minimal callus formation, are poorly understood and difficult to treat. We recently demonstrated a
Externí odkaz:
https://doaj.org/article/483f220f3d2943c89f50129305aa0a24
Autor:
Kelsey H. Collins, Lara Pferdehirt, Leila S. Saleh, Alireza Savadipour, Luke E. Springer, Kristin L. Lenz, Dominic M. Thompson, Sara J. Oswald, Christine T. N. Pham, Farshid Guilak
Publikováno v:
Gels, Vol 9, Iss 2, p 169 (2023)
Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse events. Thus, the development of improved drug delivery systems that can sense and respond co
Externí odkaz:
https://doaj.org/article/48dbb634038f487db13c04368d0f109b