Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic

Autor: Marion T.J. van den Bosch, Sanaz Yahyanejad, Mir Farshid Alemdehy, Bryony J. Telford, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 1161-1171 (2021)

Emerging data show that microRNA 193a-3p (miR-193a-3p) has a suppressive role in many cancers and is often downregulated in tumors, as compared to surrounding normal tissues. Therefore, mimics of miR-193a-3p could be used as an attractive therapeutic

Externí odkaz: https://doaj.org/article/1437daaa0d744e4094d585ba636043d3

Towards an understanding of C9orf82 protein/CAAP1 function.

Autor: Muhammad Assad Aslam, Mir Farshid Alemdehy, Colin E J Pritchard, Ji-Ying Song, Fitriari Izzatunnisa Muhaimin, Ruud H Wijdeven, Ivo J Huijbers, Jacques Neefjes, Heinz Jacobs

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210526 (2019)

C9orf82 protein, or conserved anti-apoptotic protein 1 or caspase activity and apoptosis inhibitor 1 (CAAP1) has been implicated as a negative regulator of the intrinsic apoptosis pathway by modulating caspase expression and activity. In contrast, an

Externí odkaz: https://doaj.org/article/8c34312eba3d49a2bd51d7e0f713c299

Duobody-CD3xCD30 Demonstrates Potent Anti-Tumor Activity in Preclinical Models of CD30+ Hematologic Malignancies

Autor: Simone C. Oostindie, Mir Farshid Alemdehy, Maarten L. Janmaat, Jenny M. Meerding, Kristel Kemper, Patrick J. Engelberts, Bart E.C.G. De Goeij, David Satijn, A. Kate Sasser, Esther C.W. Breij

Publikováno v: Blood. 140:3153-3154

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30553f2971d6953cdc08d7b72fc7ec1b
https://doi.org/10.1182/blood-2022-159396

The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity

Autor: Muhammad Aslam, Rozangela Curi Pedrosa, Hein te Riele, Bas Pilzecker, Olimpia Alessandra Buoninfante, Wietske Pieters, Jonne A. Raaijmakers, René H. Medema, Luiza Sheyla Evenni Porfirio Will Castro, Mir Farshid Alemdehy, Paul C.M. van den Berk, Heinz Jacobs

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff73aa9bf96c90ce30e09b978593c68
https://doi.org/10.3389/fphar.2021.596535

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8(+) T cells

Autor: Teun van den Brand, Tibor van Welsem, Mir Farshid Alemdehy, Joke M. M. den Haan, Sjoerd Hendriks, Jannie Borst, Fred van Leeuwen, Muhammad Aslam, Tessy Korthout, Elzo de Wit, Heinz Jacobs, Cesare Lancini, Eliza Mari Kwesi-Maliepaard, Chelsea M. McLean, Tomasz Ahrends, Hanneke Vlaming, Dieke van Dinther

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(34), 20706-20716. National Academy of Sciences
Kwesi-Maliepaard, E M, Aslam, M A, Alemdehy, M F, Van Den Brand, T V, McLean, C, Vlaming, H, van Welsem, T, Korthout, T, Lancini, C, Hendriks, S, Ahrends, T, van Dinther, D, den Haan, J M M, Borst, J, de Wit, E, van Leeuwen, F & Jacobs, H 2020, ' The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8 + T cells ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 34, pp. 20706-20716 . https://doi.org/10.1073/pnas.1920372117
Proceedings of the National Academy of Sciences, 117(34), 20706-20716. NATL ACAD SCIENCES

Significance Cytotoxic CD8+ T cells control infectious diseases as well as cancer. Memory T cells are a subset of CD8+ T cells that have previously encountered and rapidly responded to a specific antigen. Here we identified the epigenetic writer DOT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f4e0b0e06a07eb8799ed142a9ff0b7
https://hdl.handle.net/1887/3184225