Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Farren J"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Technologies that generate precise combinatorial genome modifications are well suited to dissect the polygenic basis of complex phenotypes and engineer synthetic genomes. Genome modifications with engineered nucleases can lead to undesirable
Externí odkaz:
https://doaj.org/article/55dfb881cd854bf78e3bfa44d467b647
Autor:
Daniel Mark Shapiro, Gunasheil Mandava, Sibel Ebru Yalcin, Pol Arranz-Gibert, Peter J. Dahl, Catharine Shipps, Yangqi Gu, Vishok Srikanth, Aldo I. Salazar-Morales, J. Patrick O’Brien, Koen Vanderschuren, Dennis Vu, Victor S. Batista, Nikhil S. Malvankar, Farren J. Isaacs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Bacterial hairs called pili become highly-conductive electric wires upon addition of both natural and synthetic amino acids conjugated with gold nanoparticles. Here the authors use computationally-guided ordering further increasing their conductivity
Externí odkaz:
https://doaj.org/article/abb6e2e28250421aabcc8f1954d83d36
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Genome editing methods are limited by the inability to selectively edit repetitive sequences. Here the authors demonstrate precise editing of a repetitive genetic element, a ribosome, while avoiding edits to native sites sharing identical sequence.
Externí odkaz:
https://doaj.org/article/87cbc3f17c704322b10da292b51f9fd2
Autor:
Ali R. Zomorrodi, Colin Hemez, Pol Arranz-Gibert, Terrence Wu, Farren J. Isaacs, Daniel Segrè
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104562- (2022)
Summary: Introducing heterologous pathways into host cells constitutes a promising strategy for synthesizing nonstandard amino acids (nsAAs) to enable the production of proteins with expanded chemistries. However, this strategy has proven challenging
Externí odkaz:
https://doaj.org/article/3dacac0bdcd745f69c3189ebbd410910
Autor:
Rey W. Martin, Benjamin J. Des Soye, Yong-Chan Kwon, Jennifer Kay, Roderick G. Davis, Paul M. Thomas, Natalia I. Majewska, Cindy X. Chen, Ryan D. Marcum, Mary Grace Weiss, Ashleigh E. Stoddart, Miriam Amiram, Arnaz K. Ranji Charna, Jaymin R. Patel, Farren J. Isaacs, Neil L. Kelleher, Seok Hoon Hong, Michael C. Jewett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Cell-free protein synthesis allows for producing proteins without the need of a host organism, thus sparing the researcher experimental hassle. Here, the authors developed a cell-free synthesis method that enables incorporating non-standard amino aci
Externí odkaz:
https://doaj.org/article/48f02766cbcf45fab8fa2795bb729a58
Publikováno v:
eLife, Vol 7 (2018)
Organisms possessing genetic codes with unassigned codons raise the question of how cellular machinery resolves such codons and how this could impact horizontal gene transfer. Here, we use a genomically recoded Escherichia coli to examine how organis
Externí odkaz:
https://doaj.org/article/2492f5c5812c46299dfc88ddc86cc4a2
Publikováno v:
Life, Vol 9, Iss 3, p 58 (2019)
The genetic code defines how information in the genome is translated into protein. Aside from a handful of isolated exceptions, this code is universal. Researchers have developed techniques to artificially expand the genetic code, repurposing codons
Externí odkaz:
https://doaj.org/article/4c349b84aca0436d9ea8c6562e169db6
Akademický článek
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Autor:
Zomorrodi, Ali R., Hemez, Colin, Arranz-Gibert, Pol, Wu, Terrence, Isaacs, Farren J., Segrè, Daniel
Publikováno v:
In iScience 15 July 2022 25(7)
Akademický článek
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