Výsledky vyhledávání - "Farrell Mackenzie"

Akademický článek

Structural characterization of human cholesterol 7α-hydroxylase

Autor: Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich

Publikováno v: Journal of Lipid Research, Vol 55, Iss 9, Pp 1925-1932 (2014)

Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol. To identify the structura

Externí odkaz: https://doaj.org/article/d9f4e2677f5a4e7b996e9e894a97ed20

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Akademický článek

Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30.

Autor: Ke Liu, Yahong Guo, Haiping Liu, Chuanbing Bian, Robert Lam, Yongsong Liu, Farrell Mackenzie, Luis Alejandro Rojas, Danny Reinberg, Mark T Bedford, Rui-Ming Xu, Jinrong Min

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30375 (2012)

SMN (Survival motor neuron protein) was characterized as a dimethyl-arginine binding protein over ten years ago. TDRD3 (Tudor domain-containing protein 3) and SPF30 (Splicing factor 30 kDa) were found to bind to various methyl-arginine proteins inclu

Externí odkaz: https://doaj.org/article/6fccd819d46f45daa02ee5d99a6f918f

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Akademický článek

Crystal structure of the human SUV39H1 chromodomain and its recognition of histone H3K9me2/3.

Autor: Tao Wang, Chao Xu, Yanli Liu, Kai Fan, Zhihong Li, Xing Sun, Hui Ouyang, Xuecheng Zhang, Jiahai Zhang, Yanjun Li, Farrell Mackenzie, Jinrong Min, Xiaoming Tu

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52977 (2012)

SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV

Externí odkaz: https://doaj.org/article/b3dbc9927d534c85821a909c3d2f083c

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Akademický článek

Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.

Autor: Haizhong Zhu, Han Youl Lee, Yufeng Tong, Bum-Soo Hong, Kyung-Phil Kim, Yang Shen, Kyung Jik Lim, Farrell Mackenzie, Wolfram Tempel, Hee-Won Park

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33943 (2012)

Kinesin-1 transports various cargos along the axon by interacting with the cargos through its light chain subunit. Kinesin light chains (KLC) utilize its tetratricopeptide repeat (TPR) domain to interact with over 10 different cargos. Despite a high

Externí odkaz: https://doaj.org/article/8ef0581f14844718bd76193ea4ed9a26

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Akademický článek

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

Autor: Tara L Davis, John R Walker, Valérie Campagna-Slater, Patrick J Finerty, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Elan Z Eisenmesser, Sirano Dhe-Paganon

Publikováno v: PLoS Biology, Vol 8, Iss 7, p e1000439 (2010)

Peptidyl-prolyl isomerases catalyze the conversion between cis and trans isomers of proline. The cyclophilin family of peptidyl-prolyl isomerases is well known for being the target of the immunosuppressive drug cyclosporin, used to combat organ trans

Externí odkaz: https://doaj.org/article/741f8b0aed584ccc95c73ca0fbd156ff

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Akademický článek

Structural studies of a four-MBT repeat protein MBTD1.

Autor: Jitka Eryilmaz, Patricia Pan, Maria F Amaya, Abdellah Allali-Hassani, Aiping Dong, Melanie A Adams-Cioaba, Farrell Mackenzie, Masoud Vedadi, Jinrong Min

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7274 (2009)

The Polycomb group (PcG) of proteins is a family of important developmental regulators. The respective members function as large protein complexes involved in establishment and maintenance of transcriptional repression of developmental control genes.

Externí odkaz: https://doaj.org/article/e086b90e4404423b93a88750d5a4de2b

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Akademický článek

Crystal structure of the N-acetylmannosamine kinase domain of GNE.

Autor: Yufeng Tong, Wolfram Tempel, Lyudmila Nedyalkova, Farrell Mackenzie, Hee-Won Park

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7165 (2009)

UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, GNE, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy. GNE is the only huma

Externí odkaz: https://doaj.org/article/5db82a4bd6b246d79a239cc7d3065ac3

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