Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Farrah El-Saafin"'
Autor:
Antonin Serrano, Tom Weber, Jean Berthelet, Farrah El-Saafin, Sreeja Gadipally, Emmanuelle Charafe-Jauffret, Christophe Ginestier, John M. Mariadason, Samantha R. Oakes, Kara Britt, Shalin H. Naik, Delphine Merino
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gol
Externí odkaz:
https://doaj.org/article/73f9b7ac183444b3acdb9541e95da71a
Autor:
Ivanka Kamenova, Pooja Mukherjee, Sascha Conic, Florian Mueller, Farrah El-Saafin, Paul Bardot, Jean-Marie Garnier, Doulaye Dembele, Simona Capponi, H. T. Marc Timmers, Stéphane D. Vincent, László Tora
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Genes encoding protein complex subunits are often dispersed in the genome of eukaryotes, raising the question how these protein complexes assemble. Here, the authors provide evidence that mammalian nuclear transcription complexes are formed co-transl
Externí odkaz:
https://doaj.org/article/bbc82790458b46f6b41118387d376ef9
Autor:
Alex R.D. Delbridge, Andrew J. Kueh, Francine Ke, Natasha M. Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E. May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J. Herold, Ygal Haupt, Gordon K. Smyth, Tim Thomas, Marnie E. Blewitt, Andreas Strasser, Anne K. Voss
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 442-454.e5 (2019)
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and
Externí odkaz:
https://doaj.org/article/09ca82a5c071461f8a7c7c4007a851a9
Autor:
Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss
Publikováno v:
Cell Death Differ
Mutations in genes encoding general transcription factors cause neurological disorders. Despite clinical prominence, the consequences of defects in the basal transcription machinery during brain development are unclear. We found that loss of the TATA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f220a01b3615cf66d97fa58ea30c26c
https://doi.org/10.1038/s41418-022-00982-5
https://doi.org/10.1038/s41418-022-00982-5
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (13), pp.7459. ⟨10.3390/ijms23137459⟩
International Journal of Molecular Sciences, 2022, 23 (13), pp.7459. ⟨10.3390/ijms23137459⟩
International audience; Ubiquitin (ub) is a small, highly conserved protein widely expressed in eukaryotic cells. Ubiquitination is a post-translational modification catalyzed by enzymes that activate, conjugate, and ligate ub to proteins. Substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1a9d9f0e495cd69311288a6c18c67
Autor:
Frédéric Hollande, David Baloyan, Antonin Serrano, Delphine Merino, Holly J. Whitfield, Robin L. Anderson, Farrah El-Saafin, Anthony T. Papenfuss, Stefano Mangiola, Verena C. Wimmer, Adam C. Parslow, Thomas Boudier, Jordan Wilcox, Matthias Ernst, Jean Berthelet, Michal Merdas, Melissa J. Davis, Steven Wilcox, Kelly L. Rogers, Bhupinder Pal, Belinda Yeo
Publikováno v:
Science Advances
Optical barcoding reveals enhanced TNFα activation and polyclonality in lung, but not liver, metastases from breast cancer.
Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network in
Intratumoral heterogeneity is a driver of breast cancer progression, but the nature of the clonal interactive network in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b740497389555fc7d0a5ea8124a771e1
http://europepmc.org/articles/PMC8262813
http://europepmc.org/articles/PMC8262813
Autor:
Marnie E. Blewitt, Tamara Beck, Yifang Hu, Francine Ke, Rose E. May, Farrah El-Saafin, Andreas Strasser, William Chiang, Lin Tai, Tim Thomas, Natasha Jansz, Megan Iminitoff, Andrew J. Kueh, Sue Haupt, Gordon K. Smyth, Marco J Herold, Alex R. D. Delbridge, Lachlan Whitehead, Gao-Yuan Wang, Anne K. Voss, Natasha Zamudio, Ygal Haupt
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 442-454.e5 (2019)
Summary: Neural tube defects (NTDs) are common birth defects in humans and show an unexplained female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete penetrance. We found that the combined loss of pro-apoptotic BIM and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cef3d31dea9f94cb71498f96a52f2a6
http://www.sciencedirect.com/science/article/pii/S221112471930364X
http://www.sciencedirect.com/science/article/pii/S221112471930364X
Autor:
Matthieu Stierle, Matej Durik, Veronique Fischer, Didier Devys, Fang Wang, Farrah El-Saafin, Laszlo Tora, Luc Negroni, Stéphane D. Vincent, Tao Ye
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2021, ⟨10.1038/s41418-021-00759-2⟩
Cell Death and Differentiation, Nature Publishing Group, 2021, 28 (8), pp.2385-2403. ⟨10.1038/s41418-021-00759-2⟩
Cell Death and Differentiation, 2021, 28 (8), pp.2385-2403. ⟨10.1038/s41418-021-00759-2⟩
Cell Death and Differentiation, Nature Publishing Group, 2021, ⟨10.1038/s41418-021-00759-2⟩
Cell Death and Differentiation, Nature Publishing Group, 2021, 28 (8), pp.2385-2403. ⟨10.1038/s41418-021-00759-2⟩
Cell Death and Differentiation, 2021, 28 (8), pp.2385-2403. ⟨10.1038/s41418-021-00759-2⟩
Co-activator complexes dynamically deposit post-translational modifications (PTMs) on histones, or remove them, to regulate chromatin accessibility and/or to create/erase docking surfaces for proteins that recognize histone PTMs. SAGA (Spt-Ada-Gcn5 A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935672ae2e64aa04dd5f75fd305d09e8
https://hal.archives-ouvertes.fr/hal-03208212/document
https://hal.archives-ouvertes.fr/hal-03208212/document
Autor:
Sascha Conic, Paul Bardot, Simona Capponi, Florian Mueller, Jean-Marie Garnier, Pooja Mukherjee, Doulaye Dembélé, Ivanka Kamenova, Farrah El-Saafin, Laszlo Tora, H. T. Marc Timmers, Stéphane D. Vincent
Publikováno v:
Nature Communications
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-09749-y⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-09749-y⟩
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-09749-y⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-09749-y⟩
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cells dedicate significant energy to build proteins often organized in multiprotein assemblies with tightly regulated stoichiometries. As genes encoding subunits assembling in a multisubunit complex are dispersed in the genome of eukaryotes, it is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef7ce86e83a73a7b0b8df132833c32f
https://hal.science/hal-02130219/document
https://hal.science/hal-02130219/document
Autor:
Farrah El-Saafin, Laszlo Tora, Timmers Hm, Sascha Conic, Simona Capponi, Paul Bardot, Florian Mueller, Jean-Marie Garnier, Mukherjee P, Doulaye Dembélé, Kamenova I, Stéphane D. Vincent
Cells dedicate significant energy to build proteins often organized in multiprotein assemblies with tightly regulated stoichiometries. As genes encoding proteins assembling in the same multisubunit complexes are dispersed in the genome of eukaryotes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa63f5add68c4af07942c4c8f63b2718
https://doi.org/10.1101/419812
https://doi.org/10.1101/419812