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Prenatal Glucocorticoid Modifies Hypothalamo-Pituitary-Adrenal Regulation in Prepubertal Guinea Pigs
Publikováno v:
Neuroendocrinology. 73:194-202
We hypothesized that exposure to synthetic glucocorticoid during rapid brain growth (d50–52, birth = 68 days) in fetal guinea pigs modifies hypothalamo-pituitary-adrenal (HPA) function after birth, and that this involves changes in central corticos
Autor:
Farrah Dean, Stephen G. Matthews
Publikováno v:
Brain research. 846(2)
Development of the fetal hypothalamo–pituitary–adrenocortical (HPA) axis is critical for fetal maturation and responses to stress. Guinea pigs, unlike rats, give birth to mature young, and peak brain growth occurs around days 48–52 (75%) of ges