Ubiquitin-mediated mechanisms of translational control

Autor: Martínez-Férriz A, Ferrando A, Fathinajafabadi A, Farràs R

Publikováno v: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Universitat Rovira i virgili (URV)

mRNAs translation to proteins constitutes an important step of cellular gene expression that is highly regulated in response to different extracellular stimuli and stress situations. The fine control of protein synthesis is carried out both qualitati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::c27d8b37bbf7d3f8ce3499ad908527b0
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3870

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mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Autor: Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A

Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation1,2. Here we show that mTORC1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. Through the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2659::824535b8c51e40827ce59dc4e0b74b8d
https://zenodo.org/record/2640538

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MA04.03 Lung Tumorspheres Characterization Reveals Cancer Stem-Like Cells Potential Targets and Prognostic Markers in Non-Small Cell Lung Cancer

Autor: Herreros-Pomares, A., Jantus-Lewintre, E., Calabuig-Fariñas, S., De-Maya-Girones, J.D., Lucas, R., Blasco, A., Guijarro, R., Martorell, M., Escorihuela, E., Chiara, M.D., Durendez-Saez, E., Gandia, C., Sirera, R., Farràs, R., Camps, C.

Publikováno v: In Journal of Thoracic Oncology October 2019 14(10) Supplement:S261-S261