Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Farnesoid X receptor (FXR)"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The farnesoid X receptor (FXR) is a crucial therapeutic target for treating non-alcoholic steatohepatitis (NASH). Although obeticholic acid (OCA) as a FXR agonist presents good efficacy, the safety data such as severe pruritus should be care
Externí odkaz:
https://doaj.org/article/454a6311bf3c4c40a22be314906d42dd
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Emodin (EMO) has the effect of anti-cholestasis induced by alpha-naphthylisothiocyanate (ANIT). But its mechanism is still unclear. The farnesoid X receptor (Fxr) is the master bile acid nuclear receptor. Recent studies have reported that Si
Externí odkaz:
https://doaj.org/article/99ba29c880a7474cb170cf025f64f9c1
Publikováno v:
Liver Research, Vol 7, Iss 4, Pp 296-303 (2023)
Over 20% of mortality during acute liver failure is associated with the development of hepatic encephalopathy (HE). Thus, HE is a complication of acute liver failure with a broad spectrum of neuropsychiatric abnormalities ranging from subclinical alt
Externí odkaz:
https://doaj.org/article/27f129de6d274fef91120034bec2282f
Publikováno v:
Cells, Vol 13, Iss 18, p 1580 (2024)
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disorder characterized by progressive cholestatic that, if untreated, can progress to liver fibrosis, cirrhosis and liver decompensation requiring liver transplant. Although the pathogen
Externí odkaz:
https://doaj.org/article/61f7122acc434a168e237e668107b7ca
Publikováno v:
Exploration of Digestive Diseases, Vol 2, Iss 2, Pp 34-43 (2023)
Hereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with disease onset within their first years. Nevertheless,
Externí odkaz:
https://doaj.org/article/efb2b2f47c55463c8153afc6c666d7d9
Autor:
Amanda Morrison, Bahaa Elgendy
Publikováno v:
Molecules, Vol 29, Iss 9, p 2022 (2024)
While FXR has shown promise in regulating bile acid synthesis and maintaining glucose and lipid homeostasis, undesired side effects have been observed in clinical trials. To address this issue, the development of intestinally restricted FXR modulator
Externí odkaz:
https://doaj.org/article/542d1553e46a4cdbb63b919f6aad271a
Publikováno v:
Shipin gongye ke-ji, Vol 44, Iss 5, Pp 363-370 (2023)
Objective: To investigate the effect of ursolic acid extracted from Hippophae rhamnoides L. on the expression of key proteins of hepatic farnesoid X receptor (FXR) signaling pathway in rats with alcoholic liver injury. Methods: The 6-week-old SPF SD
Externí odkaz:
https://doaj.org/article/6343a2b5a699447ea175b43467359f8d
Autor:
David J. Matye, Xuan Qin, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Feng Li, Tiangang Li
Publikováno v:
Liver Research, Vol 6, Iss 4, Pp 276-283 (2022)
Background and aims: Several bile acids-based monotherapies have been developed for non-alcoholic steatohepatitis (NASH) treatment but clinical trial findings suggest that they do not satisfactorily improve NASH and liver fibrosis in many patients. R
Externí odkaz:
https://doaj.org/article/beea8ecf722143c8bf8cb6f59073c383
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