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pro vyhledávání: '"Farnesoid X Receptor and Carbon Tetrachloride-Induced Liver Injury"'
Autor:
Srujana Golla, Changtao Jiang, Cen Xie, Naoki Tanaka, Frank J. Gonzalez, Kristopher W. Krausz, Shogo Takahashi, Yusuke Masuo, Marianne Polunas, Blair C. Weig, Tatsuki Fukami
Publikováno v:
Toxicological Sciences. 158:334-346
Hepatotoxicity is of major concern for humans exposed to industrial chemicals and drugs. Disruption of farnesoid X receptor (FXR), a master regulator of bile acid (BA) metabolism, enhanced the sensitivity to liver injury in mice after toxicant exposu