Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Farnaz Forghani"'
Autor:
Sylvie Desmarais, Chidambaram Ramachandran, Yves Boie, Chi-Chung Chan, Kathryn Skorey, Claude Dufresne, Deena Waddleton, Wanda Cromlish, Ernest Asante-Appiah, Robert Gordon, Lijing Xu, Patrick Roy, Farnaz Forghani, Qingping Wang, Yves Leblanc, Zhaoyin Wang, Brian P. Kennedy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1039-1042
The SAR from our peptide libraries was exploited to design a series of potent deoxybenzoin PTP-1B inhibitors. The introduction of an ortho bromo substituent next to the difluoromethylphosphonate warhead gave up to 20-fold increase in potency compared
Publikováno v:
Analytical Biochemistry. 264:216-221
The inducible form of the heme-protein prostaglandin G/H synthase (PGHS-2 or COX-2) has been established as a pivotal enzyme in the cascade of events leading to inflammation, hyperalgesia, and pyresis and represents a major therapeutic target in infl
Autor:
Brian P. Kennedy, Wanda Cromlish, Ernest Asante-Appiah, Farnaz Forghani, Yves Boie, Qingping Wang, Kathryn Skorey, Jacques Yves Gauthier, Chun Sing Li, Cheuk K. Lau, Christopher I. Bayly, Deena Waddleton, Michel Therien, Sylvie Desmarais, Chidambaram Ramachandran, Paul Payette, Giovana Scapin
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(4)
A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selecti
Publikováno v:
Moleculargeneral genetics : MGG. 242(3)
The 663 amino acid Mu transposase protein is absolutely required for Mu DNA transposition. Mutant proteins were constructed in vitro in order to locate regions of transposase that may be important for the catalysis of DNA transposition. Deletions in
Autor:
Peter C. K. Lau, Farnaz Forghani, Diane Labbé, Hélène Bergeron, Roland Brousseau, H. Joachim Höltke
Publikováno v:
Molecular and General Genetics MGG. 244:167-167