Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Farnaz Fallah-Arani"'
Autor:
Yikui Li, Helen M. Tunbridge, Graham J. Britton, Elaine V. Hill, Parisa Sinai, Silvia Cirillo, Clare Thompson, Farnaz Fallah-Arani, Simon J. Dovedi, David C. Wraith, Christoph Wülfing
Publikováno v:
Cells, Vol 10, Iss 2, p 418 (2021)
Peripheral immune regulation is critical for the maintenance of self-tolerance. Here we have investigated signaling processes that distinguish T cells with regulatory capability from effector T cells. The murine Tg4 T cell receptor recognizes a pepti
Externí odkaz:
https://doaj.org/article/706774bad1b745928cd69654126acc59
Autor:
Elaine V. Hill, Silvia Cirillo, Simon J. Dovedi, Christoph Wülfing, Helen M Tunbridge, Yikui Li, Farnaz Fallah-Arani, Clare Thompson, Parisa Sinai, David C. Wraith, Graham J. Britton
Publikováno v:
et al. 2021, ' A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability ', Cells, vol. 10, no. 2, 418, pp. 1-23 . https://doi.org/10.3390/cells10020418
Cells, Vol 10, Iss 418, p 418 (2021)
Cells
Volume 10
Issue 2
Cells, Vol 10, Iss 418, p 418 (2021)
Cells
Volume 10
Issue 2
Peripheral immune regulation is critical for the maintenance of self-tolerance. Here we have investigated signaling processes that distinguish T cells with regulatory capability from effector T cells. The murine Tg4 T cell receptor recognizes a pepti
Autor:
Oliver Zaccheo, Hanna Hailu, Shirley Jane Peters, Frank R. Brennan, Eleanor J. Ward, Rona M. Cutler, Andrew M. Ventom, Nicola L. Davies, David P. Humphreys, Farnaz Fallah-Arani, Thomas L. Pither, Tania F. Rowley, Gianluca Fossati, Louise J. Healy, Joshua M. Sopp, Mike Aylott, Katharine Cain, Alison Eddleston, John Sherington, Robert J. Griffin
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-12 (2018)
Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and subsequent pathology. We aimed to develop
Publikováno v:
Journal of Immunological Methods. 454:32-39
Immune complex (IC) deposition of IgG containing autologous antigens has been observed in autoimmunity. This can lead to IC-mediated antigen uptake and presentation by antigen presenting cells (APC) driving T cell dependent inflammation. IgG receptor
Autor:
Kevin Greenslade, H Björkelund, Alison Eddleston, Bryan Smith, Jay Tibbitts, S Crilly, F Junker, Michael D.J. Parkinson, Andrea Kiessling, Robert J. Griffin, Joanne E. Compson, Katharine Cain, Omar Qureshi, Frank R. Brennan, David P. Humphreys, Shirley Jane Peters, Farnaz Fallah-Arani, M Malmqvist, Louis Christodoulou, Nicola L. Davies, L Staelens, E. Ward, Tania F. Rowley, Thomas L. Pither
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammat
Autor:
Adnan Khan, Farnaz Fallah-Arani, Bart Vanderhoydonck, Judi Charlotte Neuss, Sarah Malcolm, Alfred Lammens, Richard J. Franklin, Lindsay K. Shuttleworth, Qiuya Huang, Jamie Henshall, Daniel James Ford, Mi-Yeon Jang, Shengqiao Li, Helen Tracey Horsley, Daniel Christopher Brookings, Mark Waer, Rodger A. Allen, Payne Andrew Charles, Yuan Lin, Eleanor Ward, Tom Ceska, Piet Herdewijn, Mark Jairaj, James Thomas Reuberson, Stefan Steinbacher, Mark Daniel Calmiano, Carl Brendan Doyle, Ling-Jie Gao, William R. Pitt, Jean Herman, Martin Augustin, Thierry Louat, Anant Ramrao Ghawalkar
Publikováno v:
Journal of medicinal chemistry. 61(15)
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target activities.
OX40 is a member of the TNFR superfamily that has potent costimulatory properties. Although the impact of blockade of the OX40–OX40 ligand (OX40L) pathway has been well documented in models of autoimmune disease, its effect on the rejection of allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524d8802a368585a343978b22357a095
https://ora.ox.ac.uk/objects/uuid:92ed85a4-7069-4172-8703-a89136b30db5
https://ora.ox.ac.uk/objects/uuid:92ed85a4-7069-4172-8703-a89136b30db5
Autor:
Frederic Geissmann, Ronjon Chakraverty, Thomas Conlan, Terry K. Means, Céline Trouillet, Farnaz Fallah-Arani, Hugh D. Goold, Barry Flutter, Laurent Chorro, Clare L. Bennett
Publikováno v:
Blood
Langerhans cells (LCs) are a distinct population of dendritic cells that form a contiguous network in the epidermis of the skin. Although LCs possess many of the properties of highly proficient dendritic cells, recent studies have indicated that they
Autor:
Megan Sykes, Ronjon Chakraverty, Barry Flutter, Clare L. Bennett, Stephen Henderson, Sara Ghorashian, Shivajanani Sivakumaran, Gordon J. Freeman, Jian-Guo Chai, Noha Edwards, Farnaz Fallah-Arani
Publikováno v:
Journal of Clinical Investigation. 120:3855-3868
Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generate graft-versus-tumor (GVT) res
Autor:
J. Sivakumaran, Ronjon Chakraverty, Clare L. Bennett, B. R. Flutter, Farnaz Fallah-Arani, Hugh D. Goold
Publikováno v:
Bone Marrow Transplantation. 45:S1-S77