Zobrazeno 1 - 10
of 714
pro vyhledávání: '"Farmakologi och toxikologi"'
Autor:
Hinojosa, M. G., Johansson, Y., Cediel Ulloa, Andrea, Ivanova, E., Gabring, N., Gliga, A., Forsby, A.
Publikováno v:
NeuroToxicology. 97:65-77
Current guidelines for developmental neurotoxicity (DNT) evaluation are based on animal models. These have limitations so more relevant, efficient and robust approaches for DNT assessment are needed. We have used the human SH-SY5Y neuroblastoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e32b39e075ff6299b782239236ec14
https://doi.org/10.1016/j.neuro.2023.05.011
https://doi.org/10.1016/j.neuro.2023.05.011
Autor:
Alhariri, Batul
Bakgrund: Det har visat sig under de senaste 20 åren att användning av aripiprazol ökar risken för spel- och impulskontrollstörningar. Aripiprazol är ett första generationens antipsykotiska läkemedel och fungerar som en partiell serotonin 5-H
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-522791
Publikováno v:
Pharmacogenomics and Personalized Medicine. 16:449-461
Background: Sub-Saharan Africa (SSA) population is genetically diverse and heterogenous thus variability in drug response among individuals is predicted to be high. Cytochrome P450 (CYP450) polymorphisms is a major source of variability in drug respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b236f2d4dac2b8220866c1d99fc5742d
https://doi.org/10.2147/pgpm.s379945
https://doi.org/10.2147/pgpm.s379945
Autor:
Gaëlle Augier, Veronika Schwabl, Asmae Lguensat, Mihai Atudorei, Osamudiamen Consoler Iyere, Sandra Eriksson Solander, Eric Augier
Publikováno v:
Neuropsychopharmacology. 48:1098-1107
Animal models of substance use disorders have been criticized for their limited translation. One important factor behind seeking and taking that has so far been largely overlooked is the availability of alternative non-drug rewards. We recently repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93667bdb933ed2a79b89d0574f96e683
https://doi.org/10.1038/s41386-022-01526-8
https://doi.org/10.1038/s41386-022-01526-8
Autor:
Rolf Gedeborg, Wilmar Igl, Bodil Svennblad, Peter Wilén, Bénédicte Delcoigne, Karl Michaëlsson, Rickard Ljung, Nils Feltelius
Publikováno v:
Pharmacoepidemiology and Drug Safety. 32:279-286
Studies of rare side effects of new drugs with limited exposure may require pooling of multiple data sources to achieve sufficient precision. In a review of all post-authorisation safety studies assessed by the EMA during 2019, 74% (20/27 comparative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37098c63e59bce936246423fab27da60
https://doi.org/10.1002/pds.5587
https://doi.org/10.1002/pds.5587
Autor:
Robin J. Svensson, Qing Xi Ooi, Lena E. Friberg, Narendra Maharaj, Pramod Kumar Reddy, Luis López‐Lázaro, Emma Hansson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:154-167
Dr. Reddy's Laboratories rituximab (DRL_RI; Dr. Reddy's Laboratories SA, Basel, Switzerland) is under development as a rituximab biosimilar. Study RI-01-002 (Clinical Trials Registry - India/2012/11/003129), comparing DRL_RI to the reference medicina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a671ede0ea47a77b372bcd6e7bb321e
https://doi.org/10.1002/psp4.12885
https://doi.org/10.1002/psp4.12885
Publikováno v:
Journal of Applied Toxicology. 43:458-469
Every day, we are exposed to many environmental pollutants that can enter our body through different routes and cause adverse effects on our health. Epidemiological studies suggest that these pollutants are responsible for approximately nine million
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e208617d4adc621783d26bdaf9a065
https://doi.org/10.1002/jat.4398
https://doi.org/10.1002/jat.4398
Autor:
Héctor M. Estévez-Silva, Germán Cuesto, Ninovska Romero, José Miguel Brito-Armas, Abraham Acevedo-Arozena, Ángel Acebes, Daniel J. Marcellino
Publikováno v:
Neurotherapeutics. 19:1566-1587
Sigma-1 receptor agonists have recently gained a great deal of interest due to their anti-amnesic, neuroprotective, and neurorestorative properties. Compounds such as PRE-084 or pridopidine (ACR16) are being studied as a potential treatment against c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901bbbc4b1a666ceb2afc0d550064810
https://doi.org/10.1007/s13311-022-01280-1
https://doi.org/10.1007/s13311-022-01280-1
Autor:
Maija Dambrova, Marina Makrecka-Kuka, Janis Kuka, Reinis Vilskersts, Didi Nordberg, Misty M. Attwood, Stefan Smesny, Zumrut Duygu Sen, An Chi Guo, Eponine Oler, Siyang Tian, Jiamin Zheng, David S. Wishart, Edgars Liepinsh, Helgi B. Schiöth
Publikováno v:
Pharmacological Reviews. 74:506-551
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy metabolism pathways. They have historically been used as important diagnostic markers for inborn errors of fatty acid oxidation and are being intensively stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50c9503b054fbb89bbe57cab7d270ac
https://doi.org/10.1124/pharmrev.121.000408
https://doi.org/10.1124/pharmrev.121.000408
Autor:
Kine Eide Kvitne, Kristine Hole, Veronica Krogstad, Birgit Malene Wollmann, Christine Wegler, Line K. Johnson, Jens K. Hertel, Per Artursson, Cecilia Karlsson, Shalini Andersson, Tommy B. Andersson, Rune Sandbu, Jøran Hjelmesæth, Eva Skovlund, Hege Christensen, Rasmus Jansson-Löfmark, Anders Åsberg, Espen Molden, Ida Robertsen
Publikováno v:
European Journal of Clinical Pharmacology
1289–1299
1289–1299
Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising endogenous CYP3A4 biomarker, add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b5a692e754f48f8824d67a5bcd8e5b
https://doi.org/10.1007/s00228-022-03336-9
https://doi.org/10.1007/s00228-022-03336-9