Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease

Autor: G. David Roodman, Thomas Lund, Ji Wang, Daniel P. Normolle, Shirong Li, Markus Y. Mapara, Jing Fu, Stephen J. Weiss, X. Edward Guo, Samuel T. Robinson, Huihui Ma, Farideh Sabeh, Rentian Feng, Suzanne Lentzsch

Publikováno v: Fu, J, Li, S, Feng, R, Ma, H, Sabeh, F, Roodman, G D, Wang, J, Robinson, S, Guo, X E, Lund, T, Normolle, D, Mapara, M Y, Weiss, S J & Lentzsch, S 2016, ' Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease ', Journal of Clinical Investigation, vol. 126, no. 5, pp. 1759-1772 . https://doi.org/10.1172/JCI80276

Multiple myeloma (MM) cells secrete osteoclastogenic factors that promote osteolytic lesions; however, the identity of these factors is largely unknown. Here, we performed a screen of human myeloma cells to identify pro-osteoclastogenic agents that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be42111afd8aece585117544bdcf82ed
https://findresearcher.sdu.dk:8443/ws/files/125852169/Multiple_myeloma_derived_MMP_13_mediates_osteoclast_fusogenesis_and_osteolytic_disease.pdf

MT1-MMP regulates the PI3Kδ·Mi-2/NuRD-dependent control of macrophage immune function

Autor: Steven L. Kunkel, Rui Liu, Wanfen Xiong, B. Timothy Baxter, Farideh Sabeh, Xiao Wei Chen, Stephen J. Weiss, Xiao Yan Li, Ryoko Shimizu-Hirota, Ivan Maillard

Publikováno v: Genes & Development. 26:395-413

Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues and orchestrate immune responses in tandem with the remodeling of the extracellular matrix (ECM). Despite the dual roles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e702410beb3fdd7a32e4a97c1d6caa62
https://doi.org/10.1101/gad.178749.111

Secreted Versus Membrane-anchored Collagenases

Autor: Stephen J. Weiss, Thomas L. Saunders, Xiao Yan Li, Farideh Sabeh, R. Grant Rowe

Publikováno v: Journal of Biological Chemistry. 284:23001-23011

Fibroblasts degrade type I collagen, the major extracellular protein found in mammals, during events ranging from bulk tissue resorption to invasion through the three-dimensional extracellular matrix. Current evidence suggests that type I collagenoly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f99a86a7e180dd8bcfa8846cac5631f0
https://doi.org/10.1074/jbc.m109.002808

Molecular Dissection of the Structural Machinery Underlying the Tissue-invasive Activity of Membrane Type-1 Matrix Metalloproteinase

Autor: Ichiro Ota, Xiao Yan Li, Ikuo Yana, Stephen J. Weiss, Farideh Sabeh

Publikováno v: Molecular Biology of the Cell. 19:3221-3233

Membrane type-1 matrix metalloproteinase (MT1-MMP) drives cell invasion through three-dimensional (3-D) extracellular matrix (ECM) barriers dominated by type I collagen or fibrin. Based largely on analyses of its impact on cell function under two-dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab20a35d61a143a9ff7c1217ae1be99
https://doi.org/10.1091/mbc.e08-01-0016

MT1-MMP–dependent neovessel formation within the confines of the three-dimensional extracellular matrix

Autor: Edward D. Allen, Kevin T. McDonagh, Tae Hwa Chun, Hedwig S. Murphy, Kenn Holmbeck, Farideh Sabeh, Henning Birkedal-Hansen, Ichiro Ota, Stephen J. Weiss

Publikováno v: The Journal of Cell Biology

During angiogenesis, endothelial cells initiate a tissue-invasive program within an interstitial matrix comprised largely of type I collagen. Extracellular matrix–degradative enzymes, including the matrix metalloproteinases (MMPs) MMP-2 and MMP-9,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8807168b7dcb95edb3c8ed4abb7794c
http://europepmc.org/articles/PMC2172577