Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Farida El Gaamouch"'
Autor:
Farida El Gaamouch, Hsiao-yun Lin, Qian Wang, Wei Zhao, Jiangping Pan, Kalena Liu, Jean Wong, Clark Wu, Chongzhen Yuan, Haoxiang Cheng, Weiping Qin, Ke Hao, Bin Zhang, Jun Wang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population. In this study, we explore the effect of high
Externí odkaz:
https://doaj.org/article/54a39f6f1c824a2b8a526cfa49487755
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer′s disease (AD) is an irreversible progressive neurodegenerative disease affecting approximately 50 million people worldwide. It is estimated to reach 152 million by the year 2050. AD is the fifth leading cause of death among Americans age
Externí odkaz:
https://doaj.org/article/b66407b0ac2e448085e79b8d9d67fc2e
Autor:
Farida El Gaamouch, Mickael Audrain, Wei-Jye Lin, Noam Beckmann, Cheng Jiang, Siddharth Hariharan, Peter S. Heeger, Eric E. Schadt, Sam Gandy, Michelle E. Ehrlich, Stephen R. Salton
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate wi
Externí odkaz:
https://doaj.org/article/20d91e074df844c7b5db2558788c3e2f
Autor:
Bin Zhang, Jianwei Hou, Min Huang, Sabrina Ng, Gregory A. Elder, Li Zhu, Mary Sano, Farida El Gaamouch, Julia Tcw, Jiqing Cao, Vahram Haroutunian, Adriana Pero, Larry Zhang, Lei Guo, Alison Goate, Dongming Cai
Publikováno v:
Molecular Psychiatry
Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP2) homeostasis to the susceptibility of developing Alzheimer’s Disease (AD). In the present study, we have identified miR-195 as a top
Autor:
Jing Wang, Jacqueline Saenz, Dongming Cai, Ping Yue Pan, Patricia Sheehan, Qian Wang, Yuanxi Zhang, Zhenyu Yue, Xianting Li, Xinyu Zhu, Insup Choi, Li Zhu, Justin Zhu, Farida El Gaamouch
Publikováno v:
Hum Mol Genet
Synaptojanin1 (synj1) is a phosphoinositide phosphatase with dual SAC1 and 5′-phosphatase enzymatic activities in regulating phospholipid signaling. The brain-enriched isoform has been shown to participate in synaptic vesicle (SV) recycling. More r
Autor:
Farida El Gaamouch, Hsiao-yun Lin, Qian Wang, Wei Zhao, Jiangping Pan, Kalena Liu, Jean Wong, Clark Wu, Chongzhen Yuan, Haoxiang Cheng, Weiping Qin, Ke Hao, Bin Zhang, Jun Wang
Publikováno v:
Scientific reports. 12(1)
Despite national and international efforts for the prevention of metabolic syndrome and its underlying diseases/disorders, its prevalence is still rising, especially in the middle-aged population. In this study, we explore the effect of high fat diet
Autor:
Stephen R.J. Salton, Michelle E. Ehrlich, Cheng Jiang, Peter S. Heeger, Mickael Audrain, Eric E. Schadt, Noam D. Beckmann, Sam Gandy, Wei-Jye Lin, Siddharth P. Hariharan, Farida El Gaamouch
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Background Multiomic studies by several groups in the NIH Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) identified VGF as a major driver of Alzheimer’s disease (AD), also finding that reduced VGF levels correlate with mean a
Autor:
Jianwei Hou, Li Zhu, Sabrina Ng, Min Huang, Jiqing Cao, Gregory A. Elder, Adriana Pero, Alison Goate, Larry Zhang, Vahram Haroutunian, Dongming Cai, Lei Guo, Farida El Gaamouch, Julia Tcw, Mary Sano, Bin Zhang
Publikováno v:
Molecular Psychiatry. 26:4563-4563
Autor:
David G. Cook, Ping Jing, Jiahong Xia, Wenjie Luo, Kole D. Meeker, Jiqing Cao, Li Zhu, Gregory A. Elder, Dongming Cai, James S. Meabon, John Bendik, Margaret B. Zhong, Farida El Gaamouch
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
The apolipoprotein E4 (ApoE4) genotype combines with traumatic brain injury (TBI) to increase the risk of developing Alzheimer’s Disease (AD). However, the underlying mechanism(s) is not well-understood. We found that after exposure to repetitive b
Publikováno v:
Journal of Alzheimer's Disease. 53:15-29
Brain lipid homeostasis plays an important role in Alzheimer's disease (AD) and other neurodegenerative disorders. Aggregation of amyloid-β peptide is one of the major events in AD. The complex interplay between lipids and amyloid-β accumulation ha