Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Farid J Ghadessy"'
Publikováno v:
Engineering Biology, Vol 6, Iss 1, Pp 17-22 (2022)
Abstract Plastic pollution in diverse terrestrial and marine environments is a widely recognised and growing problem. Bio‐recycling and upcycling of plastic waste is a potential solution to plastic pollution, as these processes convert plastic wast
Externí odkaz:
https://doaj.org/article/cd90e37e726f4219ae4296fbf51be08b
Autor:
Eunice Hui Yen Li, Barindra Sana, Timothy Ho, Ding Ke, Farid J. Ghadessy, Hung A. Duong, Jayasree Seayad
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Biocatalytic C-H halogenation is becoming increasingly attractive due to excellent catalyst-controlled selectivity and environmentally benign reaction conditions. Significant efforts have been made on enzymatic halogenation of industrial arenes in a
Externí odkaz:
https://doaj.org/article/70f54ed26d54420a9b110cbc8ee41f51
Autor:
Sharon Min Qi Chee, Jantana Wongsantichon, Lau Sze Yi, Barindra Sana, Yuri Frosi, Robert C. Robinson, Farid J. Ghadessy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Grafting bioactive peptides into recipient protein scaffolds can often increase their activities by conferring enhanced stability and cellular longevity. Here, we describe use of vGFP as a novel scaffold to display peptides. vGFP comprises G
Externí odkaz:
https://doaj.org/article/bb66fff127b041c1baa2825939769763
Autor:
Barindra Sana, Ding Ke, Eunice Hui Yen Li, Timothy Ho, Jayasree Seayad, Hung A. Duong, Farid J. Ghadessy
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1841 (2022)
Halogenation of bioactive peptides via incorporation of non-natural amino acid derivatives during chemical synthesis is a common strategy to enhance functionality. Bacterial tyrptophan halogenases efficiently catalyze regiospecific halogenation of th
Externí odkaz:
https://doaj.org/article/f48b338e0b4a4a07b8e703bd51df862a
Autor:
Sarada S. Raghavan, Sharon Chee, Juntao Li, Jeremie Poschmann, Niranjan Nagarajan, Siau Jia Wei, Chandra S. Verma, Farid J. Ghadessy
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background Acrylic acid (AA) is a widely used commodity chemical derived from non-renewable fossil fuel sources. Alternative microbial-based production methodologies are being developed with the aim of providing “green” acrylic acid. The
Externí odkaz:
https://doaj.org/article/2cf4b6574822429280b790afe43a2556
Autor:
David P. Lane, Farid J. Ghadessy, Priadarsini Maruthappan, Shifana Raja Abdeen, Teena Thakur, Pingping He, Shawn Hoon, Nick Barker, Yuezhen Xue
Upregulation of p53 target genes in response to irradiation in intestinal adenomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d4cc87c32af96c597cbcff2da9ebbe
https://doi.org/10.1158/0008-5472.22421565
https://doi.org/10.1158/0008-5472.22421565
Autor:
David P. Lane, Farid J. Ghadessy, Priadarsini Maruthappan, Shifana Raja Abdeen, Teena Thakur, Pingping He, Shawn Hoon, Nick Barker, Yuezhen Xue
p53 protein, activated and stabilized by posttranslational modifications, performs its major functions by inducing DNA repair, cell-cycle arrest, or apoptosis through transcriptional activation. Here, we determined the ability of p53 protein stabiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa8407b283c175a838e32ec7aab04e7
https://doi.org/10.1158/0008-5472.c.6510963
https://doi.org/10.1158/0008-5472.c.6510963
Autor:
David P. Lane, Farid J. Ghadessy, Priadarsini Maruthappan, Shifana Raja Abdeen, Teena Thakur, Pingping He, Shawn Hoon, Nick Barker, Yuezhen Xue
Supplementary information contains "Supplementary Materials and Methods" and "Supplementary figure legends".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3358711e5b94c47014ae9392b7d510
https://doi.org/10.1158/0008-5472.22421559.v1
https://doi.org/10.1158/0008-5472.22421559.v1
Autor:
Chandra S. Verma, Eunice H. Y. Li, Timothy Ho, Hung A. Duong, Farid J. Ghadessy, Ding Ke, Srinivasaraghavan Kannan, Jayasree Seayad, Barindra Sana
Publikováno v:
Chembiochem
Activating industrially important aromatic hydrocarbons by installing halogen atoms is extremely important in organic synthesis and often improves the pharmacological properties of drug molecules. To this end, tryptophan halogenase enzymes are potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda21bf4bf9ba1f3a8bd0a81def06f3f
https://doi.org/10.1002/cbic.202100210
https://doi.org/10.1002/cbic.202100210
Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.
Autor:
Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C Robinson, David P Lane, Christopher J Brown, Farid J Ghadessy
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189379 (2017)
As primary p53 antagonists, Mdm2 and the closely related Mdm4 are relevant cancer therapeutic targets. We have previously described a series of cell-permeable stapled peptides that bind to Mdm2 with high affinity, resulting in activation of the p53 t
Externí odkaz:
https://doaj.org/article/fdc2d7bd24ff4e5e8f8b236a8417e65d