Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Farid El Oualid"'
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110268- (2024)
Summary: The outcome of cell signaling depends not only on signal strength but also on temporal progression. We use Fluorescence Lifetime Imaging of Resonance Energy Transfer (FLIM/FRET) biosensors to investigate intracellular signaling dynamics. We
Externí odkaz:
https://doaj.org/article/31c1435066444e929e0fb686efc30850
Autor:
Lingmin Yuan, Fei Gao, Zongyang Lv, Digant Nayak, Anindita Nayak, Priscila dos Santos Bury, Kristin E. Cano, Lijia Jia, Natalia Oleinik, Firdevs Cansu Atilgan, Besim Ogretmen, Katelyn M. Williams, Christopher Davies, Farid El Oualid, Elizabeth V. Wasmuth, Shaun K. Olsen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Uba6 is an E1 enzyme that regulates numerous cellular processes by activating ubiquitin and FAT10 pathways. Here, the authors present crystal structures that illuminate Uba6 catalytic mechanisms and reveal inositol hexakisphosphate as a cofactor that
Externí odkaz:
https://doaj.org/article/8562925dd78a48dc823aff71e62cdfa1
Autor:
Aurelia Stangl, Paul R. Elliott, Adan Pinto-Fernandez, Sarah Bonham, Luke Harrison, Annalisa Schaub, Kerstin Kutzner, Kirstin Keusekotten, Paul T. Pfluger, Farid El Oualid, Benedikt M. Kessler, David Komander, Daniel Krappmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX
Externí odkaz:
https://doaj.org/article/0e6312cbac964d7aa65fe7184f4eb189
Autor:
Robbert Q. Kim, Paul P. Geurink, Monique P. C. Mulder, Alexander Fish, Reggy Ekkebus, Farid El Oualid, Willem J. van Dijk, Duco van Dalen, Huib Ovaa, Hugo van Ingen, Titia K. Sixma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a
Externí odkaz:
https://doaj.org/article/822bd4cb8eb04f3199afc82488ed53d3
Autor:
Ila van Kruijsbergen, Monique P. C. Mulder, Michael Uckelmann, Tibor van Welsem, John de Widt, Aldo Spanjaard, Heinz Jacobs, Farid El Oualid, Huib Ovaa, Fred van Leeuwen
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a lysine of a protein substrate. In addition to its wel
Externí odkaz:
https://doaj.org/article/96f73bcacfac4bcd927a6cd4d515cee0
Autor:
Dharjath Shahul Hameed, Gabrielle B. A. van Tilburg, Remco Merkx, Dennis Flierman, Hans Wienk, Farid El Oualid, Kay Hofmann, Rolf Boelens, Huib Ovaa
Publikováno v:
Frontiers in Chemistry, Vol 7 (2020)
Ubiquitination is a process in which a protein is modified by the covalent attachment of the C-terminal carboxylic acid of ubiquitin (Ub) to the ε-amine of lysine or N-terminal methionine residue of a substrate protein or another Ub molecule. Each o
Externí odkaz:
https://doaj.org/article/e816a26af1e746148099c3e686d06b53
Autor:
David S. Hewings, Johanna Heideker, Taylur P. Ma, Andrew P. AhYoung, Farid El Oualid, Alessia Amore, Gregory T. Costakes, Daniel Kirchhofer, Bradley Brasher, Thomas Pillow, Nataliya Popovych, Till Maurer, Carsten Schwerdtfeger, William F. Forrest, Kebing Yu, John Flygare, Matthew Bogyo, Ingrid E. Wertz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Deubiquitinases are proteases that cleave after the C-terminus of ubiquitin to hydrolyze ubiquitin chains and cleave ubiquitin from substrates. Here the authors describe a reactive-site-centric chemoproteomics approach to studying deubiquitinase acti
Externí odkaz:
https://doaj.org/article/a36fd9ead45149f0b851c7d214b80597
Autor:
Lizbeth Hedstrom, Farid El Oualid, Eranthie Weerapana, Yu Qian, Rory T. Coffey, Marcus J.C. Long, Ann P. Lawson
Naturally occurring ITCs cause HMW-Ub accumulation in BaF3 cells (S1); Naturally occurring ITCs do not inhibit the proteasome (S2); Natural ITCs have few functional cysteine targets in cells (S3); Activity profiling shows PEITC and BITC inhibit USP9x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486df2da85da272da3e0d0c62a7dd0d9
https://doi.org/10.1158/0008-5472.22405715
https://doi.org/10.1158/0008-5472.22405715
Autor:
Lizbeth Hedstrom, Farid El Oualid, Eranthie Weerapana, Yu Qian, Rory T. Coffey, Marcus J.C. Long, Ann P. Lawson
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdcec4bb8567f4df3c15ddc87f1b698
https://doi.org/10.1158/0008-5472.22405712.v1
https://doi.org/10.1158/0008-5472.22405712.v1
Autor:
Digant Nayak, Priscila dos Santos Bury, Marcin Drag, Alfred N. Nijkerk, Farid El Oualid, Shaun K. Olsen
Publikováno v:
Methods in Molecular Biology ISBN: 9781071628027
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a38f6ca5c309597d45b3e228906e29
https://doi.org/10.1007/978-1-0716-2803-4_11
https://doi.org/10.1007/978-1-0716-2803-4_11