Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fariborz Firooznia"'
Autor:
Stanley Wertheimer, Lee Apostle Mcdermott, Stuart Hayden, Weiya Yun, Yingsi Chen, Anjula Pamidimukkala, Rebecca Taub, Kuo-Sen Huang, Toni Whittard, Liang Guo, Shiming Li, Jenny Tan, Fariborz Firooznia, Adrian Wai-Hing Cheung, David Robert Bolin, Nicholas Marcopulos, Yimin Qian, Karin Conde-Knape, Mushtaq Ahmad, Gwendolyn Ramsey, Cristina M. Rondinone, Jefferson Wright Tilley, Matthew Michael Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 54:2433-2446
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd3abbb050006099c5ec3cd2f890db3
https://doi.org/10.1021/jm101580m
https://doi.org/10.1021/jm101580m
Autor:
Rachid Hamid, Roger David Norcross, Mary Lou Gubler, Ramakanth Sarabu, Fariborz Firooznia, Adrian Wai-Hing Cheung, John A. Brinkman, Nicholas Marcopulos, Lida Qi, Kevin Richard Guertin, Alexander Flohr, Jenny Tan, Gwendolyn Ramsey, Joseph Grimsby, Yang Wen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4140-4146
7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery of A(2B) receptor antagonists because of its slight selectivity against A(1) and A(2A) recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2103d066fa21cacca11962d6d1f7caf
https://doi.org/10.1016/j.bmcl.2010.05.056
https://doi.org/10.1016/j.bmcl.2010.05.056
Autor:
Michael E. Beil, Arco Y. Jeng, Charles W. Bruseo, Angelo J. Trapani, Fariborz Firooznia, Paula Savage
Publikováno v:
Journal of Cardiovascular Pharmacology. 44:S211-S215
CGS 35601 is a potent triple inhibitor of endothelinconverting enzyme-1, neutral endopeptidase 24.11, and angiotensinconverting enzyme. It inhibited the activities of these three enzymes with IC50 values of 55, 2 and 22 nM, respectively. In conscious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce19180c663a92a9de8fa97a727250c
https://doi.org/10.1097/01.fjc.0000166237.57077.d6
https://doi.org/10.1097/01.fjc.0000166237.57077.d6
Autor:
Nicholas Marcopoulos, Charles W. Bruseo, Candido Gude, Ying Qiao, Arco Y. Jeng, Cynthia A. Fink, Kenneth Chan, Paula Savage, Michael E. Beil, Angelo J. Trapani, Fariborz Firooznia, Yoshitaka Satoh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:375-378
Through directed screening of metalloprotease inhibitors, CGS 30084 (1) has been identified as a potent endothelin-converting enzyme-1 (ECE-1) inhibitor in vitro (IC50=77 nM). Herein we report the syntheses and biological activities of analogues deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e9eed453af106752fa074cebe8cece
https://doi.org/10.1016/s0960-894x(00)00657-0
https://doi.org/10.1016/s0960-894x(00)00657-0
Publikováno v:
Tetrahedron Letters. 40:213-216
The enantiomerically enriched BOC-protected (4-pinacolylborono)phenylalanine methyl ester (8) is produced via enzymatic resolution of the racemic material, or direct synthesis from the corresponding iodide (or triflate), and undergoes Suzuki-Miyaura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7f37684e0ae8e8fd16e1ae0f7ef5f20
https://doi.org/10.1016/s0040-4039(98)02272-2
https://doi.org/10.1016/s0040-4039(98)02272-2
Publikováno v:
Tetrahedron Letters. 39:3985-3988
The Boc-derivative of (4-pinacolylborono)phenylalanine ethyl ester (6) or the corresponding boronic acid 8 undergo Suzuki-Miyaura coupling reactions with aromatic chlorides in the presence of catalytic amounts of PdCl2(PCy3)2 or NiCl2(dppf), respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aa2b86b850c03600bc8508f322ffe26
https://doi.org/10.1016/s0040-4039(98)00749-7
https://doi.org/10.1016/s0040-4039(98)00749-7
Publikováno v:
Tetrahedron Letters. 38:7645-7648
The benzophenone imine of (4-pinacolylborono)phenylalanine ethyl ester ( 3 ) undergoes Suzuki-Miyaura coupling reactions with organic halides and triflates to give 4 -substituted phenylalanine derivatives. A homochiral boronate ester ( 7 ), derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2067ee6e99f2dd3bdecba090d1101b12
https://doi.org/10.1016/s0040-4039(97)10082-x
https://doi.org/10.1016/s0040-4039(97)10082-x
Publikováno v:
The Journal of Organic Chemistry. 60:8341-8350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6e21d698c7afce4b26ed70b3ecbead
https://doi.org/10.1021/jo00131a006
https://doi.org/10.1021/jo00131a006
Autor:
Rachid Hamid, Mary Lou Gubler, Yang Wen, Nicholas Marcopulos, Ramakanth Sarabu, Joseph Grimsby, Fariborz Firooznia, Jenny Tan, John A. Brinkman, Gwendolyn Ramsey, Adrian Wai-Hing Cheung
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(7)
The highly potent but modestly selective N-(2-amino-4-methoxy-benzothiazol-7-yl)-N-ethyl-acetamide derivative 2 was selected as the starting point for the design of novel selective A(2B) antagonists, due to its excellent potency, and good drug-like p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ede100796491a883f62581d63589c80
https://pubmed.ncbi.nlm.nih.gov/21388809
https://pubmed.ncbi.nlm.nih.gov/21388809
Publikováno v:
ChemInform. 22
3-Alkyl-2-aryloxazolidines are oxidized with 3-chloroperoxybenzoic acid to produce the corresponding oxazolidine N-oxides. These N-oxides undergo thermal rearrangement to give 2-alkyl-6-aryl-3,4-dihydro-2H-1,5,2-dioxazines in 55-85% yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8d84bd83eccd6dadee57437d2c1072
https://doi.org/10.1002/chin.199117160
https://doi.org/10.1002/chin.199117160