Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Fariba Soleymanzadeh"'
Autor:
Raymond A. Kemper, Jennifer Burke, James V. Haist, Nelamangara Nagaraja, Charles A. Kennedy, Christian Eickmeier, Stephen J. Boyer, Stéphane De Lombaert, Xin Guo, John D. Huber, Alan David Swinamer, Jeffrey B. Madwed, Anne B. Eldrup, Kirrane Thomas M, Morris Karmazyn, Fariba Soleymanzadeh, Paul Kaplita, Eugene R. Hickey, Jörg Bentzien, Elizabeth Mainolfi
Publikováno v:
Journal of Medicinal Chemistry. 55:7114-7140
Sodium-hydrogen exchanger isoform 1 (NHE1) is a ubiquitously expressed transmembrane ion channel responsible for intracellular pH regulation. During myocardial ischemia, low pH activates NHE1 and causes increased intracellular calcium levels and aber
Autor:
Stéphane De Lombaert, Ingo Muegge, Anne Bettina Eldrup, Neil A. Farrow, David Joseph, Keith McKellop, Fariba Soleymanzadeh, Chuk Chui Man, Steven John Taylor, Alison Kukulka
Publikováno v:
Journal of Medicinal Chemistry. 52:5880-5895
Inhibition of soluble epoxide hydrolase (sEH) is hypothesized to lead to an increase in circulating levels of epoxyeicosatrienoic acids, resulting in the potentiation of their in vivo pharmacological properties. As part of an effort to identify inhib
Publikováno v:
The Journal of Organic Chemistry. 65:7959-7970
Palladium-catalyzed allylic substitution and cross-coupling reactions have been combined into a sequential procedure to provide a range of disubstituted olefin products starting from two-, three-, and four-carbon common olefin templates. Diverse appl
Autor:
Fariba Soleymanzadeh, Ingo Muegge, Anne Bettina Eldrup, Isamu Akiba, Naoyuki Taki, Elizabeth Mainolfi, Saisoku Ueda, Steven John Taylor
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
Potent small molecule antagonists of the urotensin receptor are described. These inhibitors were derived via systematically deconstructing a literature inhibitor to understand the basic pharmacophore and key molecular features required to inhibit the
Autor:
Akalushi Muthukumarana, Frank M. DiCapua, Stanley Kugler, Fariba Soleymanzadeh, Glenn A. Reinhart, Rong Rhonda Chen, Margaret M. O’Neill, Jennifer Burke, Ryan M. Fryer, Roger J. Snow, Suzanne Nodop Mazurek, Jeffrey B. Madwed, Kirrane Thomas M, Roger M. Dinallo, Paul C. Harrison, Mohammed A. Kashem, Stephen J. Boyer, James D. Smith, Yunlong Zhang, Kyle E. Harrington, Xin Guo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 340(3)
We previously reported the discovery of a novel ribosomal S6 kinase 2 (RSK2) inhibitor, (R)-5-Methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a] indole-8-carboxylic acid [1-(3-dimethylamino-propyl)-1H-benzoimidazol-2-yl]-amide (BIX 02565), with
Autor:
Neil A. Farrow, Anne Bettina Eldrup, Stéphane De Lombaert, Alison Kukulka, Fariba Soleymanzadeh
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
Inhibition of sEH is hypothesized to lead to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects. In an effort to explore sEH inhibition as an avenue for the development of vasodi
Autor:
Stéphane De Lombaert, Steven John Taylor, Alisa K. Kabcenell, Neil A. Farrow, Alison Kukulka, Anne Bettina Eldrup, Fariba Soleymanzadeh, Ingo Muegge
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
A series of potent nicotinamide inhibitors of soluble epoxides hydrolase (sEH) is disclosed. This series was designed using structure-based deconstruction and a combination of two HTS hit series, resulting in hybrid analogs that retained the optimal
Autor:
John P. Wolak, Ji Wang, Hnin Hnin Khine, Peter Allen Nemoto, Chuk Chui Man, Stéphane De Lombaert, Steven S. Pullen, Hidenori Takahashi, Brian Nicholas Cook, Mohammed A. Kashem, Jörg Bentzien, Andre White, Gregory P. Roth, Fariba Soleymanzadeh, Stanley Kugler
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
Interleukin-2 inducible T-cell kinase (ITK) is a member of the Tec kinase family and is involved with T-cell activation and proliferation. Due to its critical role in acting as a modulator of T-cells, ITK inhibitors could provide a novel route to ant
Autor:
Christopher Ronald Sarko, Antonio J.M. Jr Barbosa, Kevin Chungeng Qian, Mark Stephen Ralph, Neil Moss, Ming-Hong Hao, Daniel R. Goldberg, Tazmeen N. Fadra, Faith Corbo Gaenzler, Fariba Soleymanzadeh, Rachel R. Kroe, Pingrong Liu, Abdelhakim Hammach
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(24)
A new class of benzimidazolone p38 MAP kinase inhibitors was discovered through high-throughput screening. X-ray crystallographic data of the lead molecule with p38 were used to design analogues with improved binding affinity and potency in a cell as
Publikováno v:
ChemInform. 32