Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Fariba Barahmand-Pour"'
Autor:
Peter S. Linsley, Maki Nakayama, Elisa Balmas, Janice Chen, Fariba Barahmand-pour-Whitman, Shubham Bansal, Ty Bottorff, Elisavet Serti, Cate Speake, Alberto Pugliese, Karen Cerosaletti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells from peripheral blood affect T1D progress
Externí odkaz:
https://doaj.org/article/66f2c80699f6498b86e42acf78ab840a
Autor:
Warren Anderson, Fariba Barahmand-pour-Whitman, Peter S Linsley, Karen Cerosaletti, Jane H Buckner, David J Rawlings
Publikováno v:
eLife, Vol 12 (2023)
A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA r
Externí odkaz:
https://doaj.org/article/3e6736e42d8c4ec0adf0ff3beeb58b90
Autor:
Peter S. Linsley, Fariba Barahmand-pour-Whitman, Elisa Balmas, Hannah A. DeBerg, Kaitlin J. Flynn, Alex K. Hu, Mario G. Rosasco, Janice Chen, Colin O’Rourke, Elisavet Serti, Vivian H. Gersuk, Keshav Motwani, Howard R. Seay, Todd M. Brusko, William W. Kwok, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Karen Cerosaletti
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identifie
Externí odkaz:
https://doaj.org/article/ae78e844c0644847af1e433a33d6fd7d
Autor:
Cecile M Krejsa, Rick D Holly, Mark Heipel, Ken M Bannink, Rebecca Johnson, Richard Roque, Jane Heffernan, Julie Hill, Lay Chin, Felecia Wagener, Faith Shiota, Katherine Henderson, Pallavur V Sivakumar, Hong-Ping Ren, Fariba Barahmand-Pour, Don Foster, Chris Clegg, Wayne Kindsvogel, Rafael Ponce, Steven D Hughes, Kim Waggie
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67256 (2013)
Rituximab, a monoclonal antibody targeting CD20 on B cells, is currently used to treat many subtypes of B cell lymphomas. However, treatment is not curative and response rates are variable. Recombinant interleukin-21 (rIL-21) is a cytokine that enhan
Externí odkaz:
https://doaj.org/article/75eba1524ef24901bc6062fdb1f8b56a
Autor:
Soo Jung Yang, Akhilesh K. Singh, Travis Drow, Tori Tappen, Yuchi Honaker, Fariba Barahmand-pour-Whitman, Peter S. Linsley, Karen Cerosaletti, Kelsey Mauk, Yufei Xiang, Jessica Smith, Emma Mortensen, Peter J. Cook, Karen Sommer, Iram Khan, Denny Liggitt, David J. Rawlings, Jane H. Buckner
Publikováno v:
Science Translational Medicine. 14
Adoptive transfer of regulatory T cells (T regs ) is therapeutic in type 1 diabetes (T1D) mouse models. T regs that are specific for pancreatic islets are more potent than polyclonal T regs in preventing disease. However, the frequency of antigen-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58fb79449130cbc6390214aea94ae677
https://doi.org/10.1126/scitranslmed.abn1716
https://doi.org/10.1126/scitranslmed.abn1716
Autor:
Warren Anderson, Fariba Barahmand-pour-Whitman, Peter S Linsley, Karen Cerosaletti, Jane H Buckner, David J Rawlings
A genetic variant in the gene PTPN22 (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we utilize Crispr/Cas9 gene editing with donor DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970b78a23f26aef9a9cc12a1f7c43ca7
https://doi.org/10.1101/2022.07.21.500924
https://doi.org/10.1101/2022.07.21.500924
Autor:
Elisavet Serti, Todd M. Brusko, Keshav Motwani, Fariba Barahmand-pour-Whitman, Karen Cerosaletti, Colin O’Rourke, Alex Hu, Peter S. Linsley, Janice Chen, Gerald T. Nepom, Elisa Balmas, Carla J. Greenbaum, Cate Speake, William W. Kwok, Hannah A. DeBerg, Kaitlin J. Flynn, Mario G. Rosasco, Howard R. Seay, Vivian H. Gersuk
Publikováno v:
JCI Insight
Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA sequencing (scRNA-Seq) to identify T cell receptors (TCRs) in IAR T cells, we have identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ac74b43405ccf18113a29d94d5a638
http://europepmc.org/articles/PMC8663791
http://europepmc.org/articles/PMC8663791
Autor:
Erik Wambre, Peter S. Linsley, Junbao Yang, Fariba Barahmand-pour-Whitman, Helena Reijonen, Matthew J. Dufort, Cate Speake, William W. Kwok, Raphael Gottardo, Martin Prlic, Hannah A. DeBerg, Gerald T. Nepom, Carla J. Greenbaum, James A. Eddy, Sara A. Murray, Karen Cerosaletti, Elisabeth Israelsson, Vivian H. Gersuk
Publikováno v:
The Journal of Immunology. 199:323-335
The significance of islet Ag-reactive T cells found in peripheral blood of type 1 diabetes (T1D) subjects is unclear, partly because similar cells are also found in healthy control (HC) subjects. We hypothesized that key disease-associated cells woul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ad3a30e303d73c1f94dc3d5f69cc57
https://doi.org/10.4049/jimmunol.1700172
https://doi.org/10.4049/jimmunol.1700172
Autor:
Karen, Cerosaletti, Fariba, Barahmand-Pour-Whitman, Junbao, Yang, Hannah A, DeBerg, Matthew J, Dufort, Sara A, Murray, Elisabeth, Israelsson, Cate, Speake, Vivian H, Gersuk, James A, Eddy, Helena, Reijonen, Carla J, Greenbaum, William W, Kwok, Erik, Wambre, Martin, Prlic, Raphael, Gottardo, Gerald T, Nepom, Peter S, Linsley
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(1)
The significance of islet antigen-reactive T cells found in peripheral blood of type 1 diabetes (T1D) subjects is unclear, partly because similar cells are also found in healthy control (HC) subjects. We hypothesized that key disease-associated cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e97a8390512dcade037a18bc8305c2af
https://pubmed.ncbi.nlm.nih.gov/28566371
https://pubmed.ncbi.nlm.nih.gov/28566371