Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Farial A. Tanious"'
Autor:
Farial A. Tanious, W. David Wilson, Sabrina Lusvarghi, Bruce A. Armitage, Connor T. Murphy, Danith H. Ly, Iulia Sacui, Subhadeep Roy
Publikováno v:
Journal of the American Chemical Society. 131:18415-18424
Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents. Guanine-rich peptide nucleic acid (PNA) oligomers bind to homologous DNA and RNA to form hetero-G-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b499c76f1401090eebdb2a3ff1df1afd
https://doi.org/10.1021/ja907250j
https://doi.org/10.1021/ja907250j
Autor:
W. David Wilson, Tanja Wenzler, Reto Brun, Reem K. Arafa, Mohamed A. Ismail, David W. Boykin, Farial A. Tanious
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:683-691
The key dinitrile intermediates 4a–d were synthesized by reaction of phenacyl bromide 1 and the appropriate 2-amino-5-bromopyridines to yield 3a–d. Suzuki coupling of 3a–d with 4-cyanophenylboronic acid yielded the 2,6-bis(4-cyanophenyl)-imidaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca09afa0072995d468f0bbc24c0861f
https://doi.org/10.1016/j.bmc.2007.10.042
https://doi.org/10.1016/j.bmc.2007.10.042
Publikováno v:
Biochemistry. 46:10433-10443
Guanine-rich DNA and RNA sequences are known to fold into secondary structures known as G-quadruplexes. Recent biochemical evidence along with the discovery of an increasing number of sequences in functionally important regions of the genome capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c378d762033d7b1b7c4218c3ba81f296
https://doi.org/10.1021/bi700854r
https://doi.org/10.1021/bi700854r
Autor:
Stephen Neidle, W. David Wilson, Farial A. Tanious, Anthony P. Reszka, David W. Boykin, Mohamed A. Ismail, Elizabeth W. White
Publikováno v:
Biophysical Chemistry. 126:140-153
Combining structure-specific recognition of nucleic acids with limited sequence reading is a promising method to reduce the size of the recognition unit required to achieve the necessary selectivity and binding affinity to control function. It has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dde96d71494cf5b95306de59728933
https://doi.org/10.1016/j.bpc.2006.06.006
https://doi.org/10.1016/j.bpc.2006.06.006
Autor:
Reto Brun, Tanja Wenzler, Reem K. Arafa, W. David Wilson, Chad E. Stephens, Farial A. Tanious, David W. Boykin
Publikováno v:
Journal of Medicinal Chemistry. 48:5480-5488
Dicationic guanidine, N-alkylguanidine, and reversed amidine derivatives of fused ring systems have been synthesized from their corresponding bis-amines. DNA binding studies suggest that the diguanidines and the N-alkyl diguanidines fluorenes bind in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba42dac1798dd70571a3ef565ac4256
https://doi.org/10.1021/jm058190h
https://doi.org/10.1021/jm058190h
Autor:
Chad E. Stephens, Farial A. Tanious, Amanda Mathis, W. David Wilson, David W. Boykin, James Edwin Hall, Binh Nguyen
Publikováno v:
Current Medicinal Chemistry-Anti-Cancer Agents. 5:389-408
Fluorescence microscopy of trypanosomes from drug treated mice shows that biologically active heterocyclic diamidines that target the DNA minor groove bind rapidly and specifically to parasite kinetoplast DNA (k-DNA). The observation that the kinetop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b7bc9798ee10c4b5affb0b5f7f639b
https://doi.org/10.2174/1568011054222319
https://doi.org/10.2174/1568011054222319
Autor:
Pierre Colson, Christian Bailly, Farial A. Tanious, William Laine, Christèle Tardy, Amélie Lansiaux, Reem K. Arafa, David W. Boykin, W. David Wilson
Publikováno v:
Biochemistry. 44:1941-1952
The phenanthridinium dye ethidium bromide is a prototypical DNA intercalating agent. For decades, this anti-trypanosomal agent has been known to intercalate into nucleic acids, with little preference for particular sequences. Only polydA-polydT tract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f170102dc2fe4f4d210d21d296870326
https://doi.org/10.1021/bi047983n
https://doi.org/10.1021/bi047983n
Autor:
Farial A. Tanious, W. David Wilson, Tanja Wenzler, Reto Brun, Mohamed A. Ismail, David W. Boykin
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5405-5413
A series of biphenyl benzimidazoles diamidines 6a-i were synthesized from their respective diamidoximes, through the bis-O-acetoxyamidoxime followed by hydrogenation in glacial acetic acid/ethanol in the presence of Pd-C. The target compounds contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedfc8db56e1a3e879745a3103c84d69
https://doi.org/10.1016/j.bmc.2004.07.056
https://doi.org/10.1016/j.bmc.2004.07.056
Autor:
Farial A. Tanious, Agnieska Czarny, Christian Bailly, Donald Hamelberg, David W. Boykin, W. David Wilson
Publikováno v:
Journal of the American Chemical Society. 126:143-153
A number of studies indicate that DNA sequences such as AATT and TTAA have significantly different physical and interaction properties. To probe these interaction differences in detail and determine the influence of charge, we have synthesized three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0110fa0747129056a2ac6b94158d076
https://doi.org/10.1021/ja030403+
https://doi.org/10.1021/ja030403+
Autor:
Farial A. Tanious, David W. Boykin, W. David Wilson, Judy D. Easterbrook, Reto Brun, Mohamed A. Ismail
Publikováno v:
Journal of Medicinal Chemistry. 46:4761-4769
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a), through the bis-O-acetoxyamidoxime followed by hydrogenation. Compound 4a was prepared via selective bromination of 6-(fura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2035928a59d0a3cf32505875c2b423
https://doi.org/10.1021/jm0302602
https://doi.org/10.1021/jm0302602