Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Faria, Zafar"'
Autor:
Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, L. Stanley Qi, Birgitt Schüle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or
Externí odkaz:
https://doaj.org/article/6d2236de09b34a8e9d0b88bb3b49760a
Autor:
Cheng Cheng, James Cleak, Lan Weiss, Heather Cater, Michelle Stewart, Sara Wells, Rod Carlo Columbres, Alyaa Shmara, C. Alejandra Morato Torres, Faria Zafar, Birgitt Schüle, Jonathan Neumann, Eli Hatchwell, Virginia Kimonis
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background Variants in the mitochondrial complex I assembly factor, NUBPL are associated with a rare cause of complex I deficiency mitochondrial disease. Patients affected by complex I deficiency harboring homozygous NUBPL variants typically
Externí odkaz:
https://doaj.org/article/7c848dd1a64c4810b344df2a19224ac4
Publikováno v:
Bio-Protocol, Vol 13, Iss 11 (2023)
Cell populations and tissues exhibit unique gene expression profiles, which allow for characterizing and distinguishing cellular subtypes. Monitoring gene expression of cell type–specific markers can indicate cell status such as proliferation, stre
Externí odkaz:
https://doaj.org/article/784d50e6c8d3488795859b2bd9c85074
Autor:
C. Alejandra Morato Torres, Faria Zafar, Yu-Chih Tsai, Jocelyn Palafox Vazquez, Michael D. Gallagher, Ian McLaughlin, Karl Hong, Jill Lai, Joyce Lee, Amanda Chirino-Perez, Angel Omar Romero-Molina, Francisco Torres, Juan Fernandez-Ruiz, Tetsuo Ashizawa, Janet Ziegle, Francisco Javier Jiménez Gil, Birgitt Schüle
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100137- (2022)
Summary: Spinocerebellar ataxia type 10 (SCA10) is an autosomal-dominant disorder caused by an expanded pentanucleotide repeat in the ATXN10 gene. This repeat expansion, when fully penetrant, has a size of 850–4,500 repeats. It has been shown that
Externí odkaz:
https://doaj.org/article/d277d02bf6d7434f953472087dacb93d
Publikováno v:
Bio-Protocol, Vol 12, Iss 14 (2022)
To optimize differentiation protocols for stem cell-based in vitro modeling applications, it is essential to assess the change in gene expression during the differentiation process. This allows controlling its differentiation efficiency into the targ
Externí odkaz:
https://doaj.org/article/b56033146b874fcc9d04de17dbcc15c2
Autor:
Faria Zafar, Vasavi Nallur Srinivasaraghavan, Max Yang Chen, C. Alejandra Morato Torres, Birgitt Schüle
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102733- (2022)
Alpha-synuclein overexpression and aggregation are critical factors in the pathogenesis of Parkinson’s disease (PD). Clinical cases with alpha-synuclein (SNCA) multiplications or deletions indicate that gene expression levels are essential for neur
Externí odkaz:
https://doaj.org/article/460e4237bc484f0993b82d999b252275
Autor:
Rodrigo Ramos-Acevedo, Carmen Alejandra Morato-Torres, Francisco J. Padilla-Godínez, Luis Daniel Bernal-Conde, Marcela Palomero-Rivero, Faria Zafar, Omar Collazo-Navarrete, Luis O. Soto-Rojas, Birgitt Schüle, Magdalena Guerra-Crespo
Publikováno v:
Brain Sciences, Vol 13, Iss 2, p 329 (2023)
Transplantation of immature dopaminergic neurons or neural precursors derived from embryonic stem cells (ESCs) into the substantia nigra pars compacta (SNpc) is a potential therapeutic approach for functional restitution of the nigrostriatal pathway
Externí odkaz:
https://doaj.org/article/1d45d50c41184c48adcfac0d23cdc69b
Autor:
Valerio Napolioni, Carolyn A. Fredericks, Yongha Kim, Divya Channappa, Raiyan R. Khan, Lily H. Kim, Faria Zafar, Julien Couthouis, Guido A. Davidzon, Elizabeth C. Mormino, Aaron D. Gitler, Thomas J. Montine, Birgitt Schüle, Michael D. Greicius
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 160 (2022)
We describe the clinical and neuropathologic features of patients with Lewy body spectrum disorder (LBSD) carrying a nonsense variant, c.604C>T; p.R202X, in the glucocerebrosidase 1 (GBA) gene. While this GBA variant is causative for Gaucher’s dise
Externí odkaz:
https://doaj.org/article/40074ee275614b8e86ad41dac1b0fb5f
Autor:
Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, Stanley Qi, Birgitt Schüle
Publikováno v:
bioRxiv
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6037f877f518eb5bd4e743384a14e394
https://doi.org/10.1101/2023.01.24.525105
https://doi.org/10.1101/2023.01.24.525105
Autor:
Rodrigo Ramos-Acevedo, Carmen Alejandra Morato-Torres, Luis Daniel Bernal-Conde, Francisco Javier Padilla-Godínez, Marcela Palomero-Rivero, Faria Zafar, Birgitt Schüle, Magdalena Guerra-Crespo
Background: Degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD) is responsible for motor and cognitive impairment. Replacing the dopaminergic cell population in the SNpc to restore normal dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d292e12fdbbcc1997b14b14c8b208fa
https://doi.org/10.21203/rs.3.rs-2085626/v1
https://doi.org/10.21203/rs.3.rs-2085626/v1