Výsledky vyhledávání - "Farhana Sakloth"

An investigation of the optical isomers of methcathinone (MCAT), and two achiral analogs, at monoamine transporters and in intracranial self- stimulation studies in rats

Autor: Farhana Sakloth, Rachel A. Davies, Vy T. Nguyen, Tyson R. Baird, Brian Ruiz, Richard A. Glennon, Jose M. Eltit, S. Stevens Negus

Publikováno v: ACS Chem Neurosci

Methcathinone (MCAT; 1), the progenitor of numerous and widely abused “synthetic cathinone” central stimulants, exists as a pair of optical isomers. Although S(−)MCAT is several-fold more potent than R(+)MCAT in rodent locomotor stimulation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f81c147080309aafac54b89c3cb3c9
https://europepmc.org/articles/PMC10019599/

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HDAC6-selective inhibitors decrease nerve-injury and inflammation-associated mechanical hypersensitivity in mice

Autor: Kerri D. Pryce, Kleopatra Avrampou, Lefteris Manouras, Valeria Cogliani, Vasiliki Mitsi, Venetia Zachariou, Olivier Berton, Farhana Sakloth, Randal A. Serafini, Matthew Jarpe

Publikováno v: Psychopharmacology (Berl)

BACKGROUND: HDAC6 is a class IIB histone deacetylase expressed at many levels of the nociceptive pathway. This study tested the ability of novel and selective HDAC6 inhibitors to alleviate sensory hypersensitivity behaviors in mouse models of periphe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82412ee760cd897ea2f18b6be51fcd45
https://europepmc.org/articles/PMC7470631/

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Regulators of G Protein Signaling in Analgesia and Addiction

Autor: Venetia Zachariou, Feodora Bertherat, Farhana Sakloth, Claire Polizu

Publikováno v: Mol Pharmacol

Regulator of G protein signaling (RGS) proteins are multifunctional proteins expressed in peripheral and neuronal cells, playing critical roles in development, physiologic processes, and pharmacological responses. RGS proteins primarily act as GTPase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f113981fcb52dafba3eb14981e54cf0e
https://pubmed.ncbi.nlm.nih.gov/32474445

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Effects of N-Alkyl-4-Methylamphetamine Optical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related Behavior

Autor: Umberto Maria Battisti, Michael H. Baumann, Donna Walther, Iwona Ruchala, Farhana Sakloth, Jose M. Eltit, Richard A. Glennon, Sidney S. Negus, Alan S. Harris, Ramsey Sitta

Publikováno v: ACS Chemical Neuroscience. 9:1829-1839

4-Methylamphetamine (4-MA) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT), thereby causing non-exocytotic release of monoamine transmitters via reve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d5d7864eadf9e04f213a772a682fa2
https://doi.org/10.1021/acschemneuro.8b00138

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A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Autor: Feodora Bertherat, Bryan L. Roth, Tao Che, K. Toth, Kerri D. Pryce, H. U. Kaniskan, Michael D. Cameron, Jian Jin, Yun Liu, Abhijeet Kapoor, L. Qin, Marta Filizola, Venetia Zachariou, Farhana Sakloth, A. Nicolais, Susan Khan, Hye Jin Kang

Publikováno v: Neuropharmacology

Positive allosteric modulators (PAMs) of the µ-opioid receptor (MOR) have been proposed to exhibit therapeutic potential by maximizing the analgesic properties of clinically used opioid drugs while limiting their adverse effects or risk of overdose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cfb57c86eab2aa35a0a312c58c6c3f
https://doi.org/10.1016/j.neuropharm.2021.108673

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N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability

Autor: Michael H. Baumann, John S. Partilla, S. Stevens Negus, Farhana Sakloth, Ernesto Solis, Kathryn L. Schwienteck, Iwona Ruchala, Louis J. De Felice, Richard A. Glennon, Jose M. Eltit

Publikováno v: Neuropsychopharmacology. 42:1950-1961

Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively). 4-Methylamphetamine (4-MA) is an emerging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a328bddfdf60d37d43eec0f2a198dc0
https://doi.org/10.1038/npp.2017.98

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RGS4 Maintains Chronic Pain Symptoms in Rodent Models

Autor: Li Shen, Sevasti Gaspari, Barbara Ligas, Aarthi Ramakrishnan, Vasiliki Mitsi, Claire Polizu, Kerri D. Pryce, Cole Swartz, Randal A. Serafini, Kleopatra Avrampou, Fiona B. Carr, Venetia Zachariou, Farhana Sakloth, Abigail Richards

Regulator of G-protein signaling 4 (RGS4) is a potent modulator of G-protein-coupled receptor signal transduction that is expressed throughout the pain matrix. Here, we use genetic mouse models to demonstrate a role of RGS4 in the maintenance of chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7752d5a57804e99589d6757b9fe4e7d7
https://europepmc.org/articles/PMC6794935/

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