Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Farhana F, Merzoug"'
Autor:
David A. Schaer, Richard P. Beckmann, Jack A. Dempsey, Lysiane Huber, Amelie Forest, Nelusha Amaladas, Yanxia Li, Ying Cindy Wang, Erik R. Rasmussen, Darin Chin, Andrew Capen, Carmine Carpenito, Kirk A. Staschke, Linda A. Chung, Lacey M. Litchfield, Farhana F. Merzoug, Xueqian Gong, Philip W. Iversen, Sean Buchanan, Alfonso de Dios, Ruslan D. Novosiadly, Michael Kalos
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2978-2994 (2018)
Summary: Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), has recently been approved for the treatment of hormone receptor-positive breast cancer. In this study, we use murine syngeneic tumor models and in vitro assays to inves
Externí odkaz:
https://doaj.org/article/1595454cd7fc4830988cdc917336d3e6
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
LY3295668 chemical characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459c3119cab021ba3189b2c2e7d96d2e
https://doi.org/10.1158/2159-8290.22533034.v1
https://doi.org/10.1158/2159-8290.22533034.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
shRNA suppressor screening data for H446 and MDA-MB-468 cells (tabs 1, 2) and RNA expression level associations with LY3295668 Abs IC50 values from 493 cancer cell lines (tab 3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7062b69c7f18848d7e882885812c96
https://doi.org/10.1158/2159-8290.22533025.v1
https://doi.org/10.1158/2159-8290.22533025.v1
Autor:
Sean G. Buchanan, James R. Henry, Robert M. Campbell, Christoph Reinhard, Gregory D. Plowman, David A. Barda, Xiang S. Ye, Hui-Rong Qian, Shaoyou Chu, Thompson Doman, Matthew Z. Dieter, Yu-Hua Hui, Scott W. Eastman, María José Lallena, Carmen Baquero, Carlos Marugán, Michele Dowless, Stephen R. Wasserman, Kenneth Weichert, Anna Pustilnik, Danalyn Manglicmot, Karen Froning, Ann M. Mc Nulty, Stephen Antonysamy, Avnish Kapoor, Li Fan, Chris Ficklin, Huimin Bian, Sufang Yao, Shaoling Jin, Bomie Han, Wayne Blosser, Xi Lin, Robert D. Van Horn, Li-Chun Chio, Philip W. Iversen, Yue Webster, Farhana F. Merzoug, Stephen H. Parsons, Jian Du, Xueqian Gong
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071e82c7fa2f25274a31dc41f9817c55
https://doi.org/10.1158/2159-8290.22533037
https://doi.org/10.1158/2159-8290.22533037
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Supplementary Table 1. In vitro anticancer activity of LY2523355 against a panel of commonly used cancer cell lines; supplementary Table 2. Anticancer activity of LY2523355 in NCI-60 assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a65911a747f00062ac61a9596c14f42
https://doi.org/10.1158/1535-7163.22506618.v1
https://doi.org/10.1158/1535-7163.22506618.v1
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Intervention of cancer cell mitosis by antitubulin drugs is among the most effective cancer chemotherapies. However, antitubulin drugs have dose-limiting side effects due to important functions of microtubules in resting normal cells and are often re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed1dda9c315451439788b0da0e62655
https://doi.org/10.1158/1535-7163.c.6538446.v1
https://doi.org/10.1158/1535-7163.c.6538446.v1
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Supplementary Figure 1 (A-C). LY2523355 has potent and selective activity against microtubule-stimulated Eg5 ATPase activity but unlike antitubulins, has no effect on microtubule dynamics in vitro; supplementary Figure 2 (A-E). LY2523355 causes cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0327deaa062a75d5daccf35952d6b60e
https://doi.org/10.1158/1535-7163.22506624
https://doi.org/10.1158/1535-7163.22506624
Autor:
Eric H. Westin, Kerry Blanchard, Amit Aggarwal, Heng Li, Farhana F. Merzoug, Gregory P. Donoho, Kelly M. Credille, Tinggui Yin, Yoshinori Yamashita, Chikara Murakata, Shiro Akinaga, Yoshihisa Ohta, Ryuichiro Nakai, Robert D. Van Horn, Li Fan, Xiang S. Ye
Figure Legends to supplementary Figures 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acf89d9470e8c0b4b636be6a70853a0
https://doi.org/10.1158/1535-7163.22506621.v1
https://doi.org/10.1158/1535-7163.22506621.v1
Autor:
Jennifer R. Stephens, Sean Buchanan, Farhana F. Merzoug, Manisha Brahmachary, Ann M. McNulty, Lacey M. Litchfield, Xiang S. Ye, Karsten Boehnke, Xueqian Gong, Wenjuan Wu, Valerie M. Jansen, J. Michael Sauder, Chen Bi, Sonia M Gutiérrez, Maria Jose Lallena, Cecilia Mur
Publikováno v:
Oncotarget
Aberrant activation of mitogenic signaling pathways in cancer promotes growth and proliferation of cells by activating mTOR and S6 phosphorylation, and D-cyclin kinases and Rb phosphorylation, respectively. Correspondingly, inhibition of phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55847514b17b3b5d7172cd46af4a4393
http://europepmc.org/articles/PMC7197449
http://europepmc.org/articles/PMC7197449
Autor:
Samuel McNeely, Xin Tian You, Ann M. McNulty, Sean Buchanan, Wayne Blosser, Yue Webster, Gregory P. Donoho, Farhana F. Merzoug, Ricardo Martinez, Philip J. Ebert, Karsten Boehnke, Aimee Bence Lin, Xi Rao, Philip W. Iversen, Xueqian Gong, Richard P. Beckmann, Wenjuan Wu, Jack A. Dempsey, Chunping Yu, Caitlin D. Lowery
Publikováno v:
Oncotarget
The combined influence of oncogenic drivers, genomic instability, and/or DNA damage repair deficiencies increases replication stress in cancer. Cells with high replication stress rely on the upregulation of checkpoints like those governed by CHK1 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fdf2523c5cbc32f54448b3d0af1856
https://doi.org/10.18632/oncotarget.27400
https://doi.org/10.18632/oncotarget.27400