Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Farhad Parhami"'
Autor:
Frank Stappenbeck, Feng Wang, Satyesh K. Sinha, Simon T. Hui, Lia Farahi, Nigora Mukhamedova, Andrew Fleetwood, Andrew J. Murphy, Dmitri Sviridov, Aldons J. Lusis, Farhad Parhami
Publikováno v:
Cells, Vol 13, Iss 19, p 1632 (2024)
Background and aims: We previously reported that Oxy210, an oxysterol-based drug candidate, exhibits antifibrotic and anti-inflammatory properties. We also showed that, in mice, it ameliorates hepatic hallmarks of non-alcoholic steatohepatitis (NASH)
Externí odkaz:
https://doaj.org/article/650e6a06b1ad4cdc92e89f9bd3345b48
Autor:
Liu-Ya Tang, Marie Spezia, Ting Chen, Jee-Hye Shin, Feng Wang, Frank Stappenbeck, Andres M. Lebensohn, Farhad Parhami, Ying E. Zhang
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Background Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation. They are often constitutively activated in many human malignancies, incl
Externí odkaz:
https://doaj.org/article/86845e099f0c423ab6788917d92ebb70
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 114 (2023)
Oxy210, a semi-synthetic oxysterol derivative, displays cell-selective inhibition of Hedgehog (Hh) and transforming growth factor beta (TGF-β) signaling in epithelial cells, fibroblasts, and macrophages as well as antifibrotic and anti-inflammatory
Externí odkaz:
https://doaj.org/article/76e749a7adde4bcea4052cce279fd3c7
Autor:
Simon T. Hui, Feng Wang, Frank Stappenbeck, Samuel W. French, Clara E. Magyar, Farhad Parhami, Aldons J. Lusis
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 4, Iss 4, Pp n/a-n/a (2021)
Abstract Aims Non‐alcoholic steatohepatitis (NASH) is associated with increased overall morbidity and mortality in non‐alcoholic fatty liver disease (NAFLD) patients. Liver fibrosis is the strongest prognostic factor for clinical outcomes, liver
Externí odkaz:
https://doaj.org/article/3dc9a6b25b8f4f7c922167c97f1ed8d6
Publikováno v:
Cells, Vol 8, Iss 10, p 1297 (2019)
Non-Small Cell Lung Cancer (NSCLC) is a common malignancy and leading cause of death by cancer. Metastasis and drug resistance are serious clinical problems encountered in NSCLC therapy. Aberrant activation of the Transforming Growth Factor beta (TGF
Externí odkaz:
https://doaj.org/article/10b09b7e4df84416994f30f1d6256b8c
Publikováno v:
Cells, Vol 8, Iss 5, p 509 (2019)
The widespread involvement of the Hedgehog (Hh) signaling pathway in human malignancies has motivated the clinical development of Smoothened (Smo) antagonists, such as vismodegib and sonidegib. However, Smo antagonists have failed to benefit patients
Externí odkaz:
https://doaj.org/article/ff26fefc08004caea5d2eddf9d32a77e
Autor:
William Matsui, Farhad Parhami, Carol Ann Huff, Ivan Borrello, Nilanjan Ghosh, Akil Merchant, Zeshaan Rasheed, Toshihiko Tanno, Qiuju Wang, Jasmin R. Agarwal
The Hedgehog (Hh) signaling pathway is aberrantly activated in a wide variety of human cancers, and recent clinical studies have demonstrated that pathway inhibitors are effective in advanced basal cell carcinoma (BCC). The majority of these agents h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e657e1f4ccdc4b62605c35914fdf52
https://doi.org/10.1158/1535-7163.c.6536604.v1
https://doi.org/10.1158/1535-7163.c.6536604.v1
Autor:
William Matsui, Farhad Parhami, Carol Ann Huff, Ivan Borrello, Nilanjan Ghosh, Akil Merchant, Zeshaan Rasheed, Toshihiko Tanno, Qiuju Wang, Jasmin R. Agarwal
PDF - 177K, Figure S1. LXR expression in myeloma cell lines. Figure S2. Induction of LXR target genes by non-steroidal LXR agonists. Figure S3. Effects of LXR agonists on clonogenic myeloma growth. Figure S4. Impact of T0901317 on myeloma cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b48495a3fa945ae8d6c2bfcaa147b54
https://doi.org/10.1158/1535-7163.22500882.v1
https://doi.org/10.1158/1535-7163.22500882.v1
Autor:
Kouji Kuramochi, Tadaki Suzuki, Camille Sureau, Farhad Parhami, Wakana Saso, Masamichi Muramatsu, Takaji Wakita, Chisa Kobayashi, Masako Yamasaki, Feng Wang, Kana Tsuchimoto, Michiyo Kataoka, Koichi Watashi, Makoto Takeda, Hirofumi Ohashi, Frank Stappenbeck
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 3163, p 3163 (2021)
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 3163, p 3163 (2021)
Volume 22
Issue 6
The development of effective antiviral drugs targeting the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is urgently needed to combat the coronavirus disease 2019 (COVID-19). We have previously studied the use of semi-synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefdd01c77d818f517e81bdda8516804
https://pubmed.ncbi.nlm.nih.gov/33808940
https://pubmed.ncbi.nlm.nih.gov/33808940
Autor:
Hirofumi Ohashi, Kana Tsuchimoto, Kouji Kuramochi, Tadaki Suzuki, Farhad Parhami, Makoto Takeda, Masamichi Muramatsu, Koichi Watashi, Michiyo Kataoka, Camille Sureau, Takaji Wakita, Wakana Saso, Feng Wang, Chisa Kobayashi, Frank Stappenbeck
Development of effective antiviral drugs targeting the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) are urgently needed to combat the coronavirus disease 2019 (COVID-19). Oxysterols, defined as oxidized derivatives of choleste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07abc0e053ee1699656ee01db6d1ab9d
https://doi.org/10.1101/2021.01.31.429001
https://doi.org/10.1101/2021.01.31.429001